Full Project 1: LSR Alters Metabolic Signaling to Drive Aggressive Breast Cancer Behaviors

完整项目 1:LSR 改变代谢信号以驱动侵袭性乳腺癌行为

基本信息

  • 批准号:
    10247134
  • 负责人:
  • 金额:
    $ 3.11万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-09-28 至 2022-08-31
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract African American (AA) women have higher breast cancer mortality rates compared to other races. A greater prevalence of basal-like breast cancers in AA women explain some disparities, as these tumors are clinically the most aggressive, characterized by cancer stem No effective therapies exist and cell features. survival is poor. Escalating this disparity is the disease promoting effects of obesity, which is significantly higher in AA. The majority of studies on breast cancer disparities examine tumor characteristics, but the etiologic factors that lead to this disparity remain undefined. Our primary objective is to identify the mechanisms involved in promoting aggressive breast cancer in AAs, as a consequence of stromal effects at the site of the cancerous lesion. A key molecular pathway has been identified which integrates these clinical, microenvironmental and biological factors to affect tumor behavior. Aim 1 takes a novel approach, combining our published proteomic and gene expression datasets detailing race and tumor-subtype specific stromal interactions with our recently published data on the identified pathway promoting cancer stem cell- like, aggressive behaviors. Aims 2 and 3 extend these data to experimental studies to elucidate mechanistic details. To accomplish these tasks, our team established research partnerships that provides access to resources including the Normal Breast Study: a unique epidemiologic study from ethnically diverse patients at UNC Hospitals. There are several important biological implications of this work. The observation that AA breast tissue is enriched with distinct proteins, the prevalence of obesity in AA, and the predisposition to develop basal-like tumors strongly suggests a biological link between race, metabolism and cancer subtype. The role of differentially regulated metabolic-sensitive proteins in the tumor microenvironment will provide novel insights into the biological basis of racial disparities. The long-term goal of our collaboration is to understand tumor-microenvironment interactions and their influence on breast cancer disparities. Our distinctive approach will expose unique characteristics of the breast tissue microenvironment and will integrate advances in the field of tumor microenvironment with health disparities research. Relevance This proposal addresses breast cancer disparities by studying a key pathway that drive the aggressiveness of breast cancers. By combining observational studies on differences in this pathway by race, BMI, and breast cancer subtype with experimental studies to understand the role of this pathway in cellular phenotypes, this project will provide important and novel insight into the biological basis of racial disparities.
项目总结/文摘

项目成果

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Keith Burridge其他文献

Keith Burridge的其他文献

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{{ truncateString('Keith Burridge', 18)}}的其他基金

Endothelial Cell Uptake of Infected Erythrocytes in Cerebral Malaria
脑型疟疾中感染红细胞的内皮细胞摄取
  • 批准号:
    9112857
  • 财政年份:
    2015
  • 资助金额:
    $ 3.11万
  • 项目类别:
Endothelial Cell Uptake of Infected Erythrocytes in Cerebral Malaria
脑型疟疾中感染红细胞的内皮细胞摄取
  • 批准号:
    8969179
  • 财政年份:
    2015
  • 资助金额:
    $ 3.11万
  • 项目类别:
Rho-mediated Signaling in Lung Endothelial Cells Induced by Neutrophil Adhesion
中性粒细胞粘附诱导的肺内皮细胞中 Rho 介导的信号传导
  • 批准号:
    8321142
  • 财政年份:
    2012
  • 资助金额:
    $ 3.11万
  • 项目类别:
Rho-mediated Signaling in Lung Endothelial Cells Induced by Neutrophil Adhesion
中性粒细胞粘附诱导的肺内皮细胞中 Rho 介导的信号传导
  • 批准号:
    8473275
  • 财政年份:
    2012
  • 资助金额:
    $ 3.11万
  • 项目类别:
Rho-mediated Signaling in Lung Endothelial Cells Induced by Neutrophil Adhesion
中性粒细胞粘附诱导的肺内皮细胞中 Rho 介导的信号传导
  • 批准号:
    8651535
  • 财政年份:
    2012
  • 资助金额:
    $ 3.11万
  • 项目类别:
Full Project 1: LSR Alters Metabolic Signaling to Drive Aggressive Breast Cancer Behaviors
完整项目 1:LSR 改变代谢信号以驱动侵袭性乳腺癌行为
  • 批准号:
    9044449
  • 财政年份:
    2010
  • 资助金额:
    $ 3.11万
  • 项目类别:
CB2 Cannabinoid Receptor-mediated Regulation of Prostate Cancer Growth
CB2 大麻素受体介导的前列腺癌生长调节
  • 批准号:
    8068504
  • 财政年份:
    2010
  • 资助金额:
    $ 3.11万
  • 项目类别:
Cell Adhesion and the Regulation of Rho GTPases
细胞粘附和 Rho GTP 酶的调节
  • 批准号:
    7999960
  • 财政年份:
    2009
  • 资助金额:
    $ 3.11万
  • 项目类别:
CYTOSKELETAL REGULATION OF ENDOTHELIAL CELL JUNCTIONS
内皮细胞连接的细胞骨架调节
  • 批准号:
    7474511
  • 财政年份:
    2007
  • 资助金额:
    $ 3.11万
  • 项目类别:
BIOSENSOR
生物传感器
  • 批准号:
    7313480
  • 财政年份:
    2006
  • 资助金额:
    $ 3.11万
  • 项目类别:

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