Developmental Research Program

发展研究计划

• 批准号: 10244967
• 负责人: ULRIKE PETERS
• 金额: $ 2.57万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10244967
• 关键词: Advertising; Applications Grants; Area; Award; Collaborations; Colorectal Cancer; Communities; Development; Discipline; Early Diagnosis; Epidemiology; Evaluation; Faculty; Financial Support; Fostering; Funding; Goals; Grant; Guidelines; Infrastructure; Institution; Malignant Neoplasms; Manuscripts; Molecular Biology; Monitor; Morbidity - disease rate; Oral; Outcome; Pathology; Peer Review; Phase; Primary Prevention; Prognosis; Program Research Project Grants; Research; Research Personnel; Research Project Grants; Research Proposals; Sampling; Secondary Prevention; Structure; Therapeutic; Translational Research; United States National Institutes of Health; cancer health disparity; career; ethnic diversity; innovation; interest; medically underserved population; mortality; new technology; novel; programs; racial and ethnic; research and development; success; survivorship; translational research program

Project Summary/Abstract of the Development Research Program The Developmental Research Program (DRP) will provide key support to develop novel translational early-phase Projects in the area of cancer disparities that, ultimately, will contribute to the reduction in the morbidity and mortality of cancer among medically underserved populations. In line with the overall goals of our Translational Research Program in Colorectal Cancer Disparities. The DRP will foster new collaborations between participating institutions and initiate collaborations with other SPOREs and Disparities P20’s. Additionally, our Career Enhancement Program (operated through our Administrative Core) will encourage early career investigators, particularly those from racially/ethnically diverse backgrounds, to apply to the DRP. Our goal is to fund Developmental Research Projects encompassing a range of translational cancer disparities research, including molecular biology, epidemiology (primary and secondary prevention), early detection, prognosis, therapeutics, and survivorship. To achieve this goal, we will identify promising translational cancer disparities Research Projects through broad solicitation (Aim 1). We will encourage early and senior investigators to collaborate across multiple disciplines. New ideas will be solicited on an annual basis by broadly advertising pilot funding and targeted engagement with promising faculty. Aim 2 will focus on rigorous and balanced scientific review of DRP proposals. We will convene an expert panel encompassing a broad range of scientific disciplines and also include participation from our Community Advisory Board. We will follow the National Institutes of Health SPORE guidelines for these reviews. In addition to financial support, funded DRP Projects will receive strong infrastructure support and access to biospecimens and expertise related to novel technologies through our Administrative and Biospecimen and Pathology Cores (Aim 3). With our generous institutional matching support we will award $100,000 of funding to DRP projects annually and anticipate that each year we will fund about 3 one-year projects. The progress of all DRP projects will be monitored regularly with respect to achieving their specific aims and milestones using clearly defined evaluation criteria (Aim 4). Of particular interest will be the potential of each project to advance to a full SPORE Project. We will also track long-term reportable outcomes of each project such as peer-reviewed manuscripts, oral presentations and grant funding.

项目概要/发展研究计划摘要 发展研究计划（DRP）将提供关键支持，以开发新的翻译 癌症差异领域的早期项目，最终将有助于减少 癌症发病率和死亡率在医疗服务不足的人群中。按照《2010年世界粮食计划署 我们在结直肠癌差异的转化研究计划。DRP将促进新的合作 参与机构之间的合作，并启动与其他SPORE和差异P20的合作。 此外，我们的职业提升计划（通过我们的行政核心运作）将鼓励 早期职业调查员，特别是那些来自种族/民族不同背景的人，申请DRP。 我们的目标是资助发展研究项目，包括一系列转化癌症差异 研究，包括分子生物学、流行病学（一级和二级预防）、早期发现， 预后、治疗和存活率。为了实现这一目标，我们将确定有希望的转化癌 通过广泛征集的研究项目（目标1）。我们将鼓励早期和老年人 调查人员在多个学科之间进行合作。每年将征求新的想法， 广泛宣传试点资金，并有针对性地与有前途的教师接触。目标2将侧重于严格的 对DRP提案进行平衡的科学审查。我们将召集一个专家小组， 一系列科学学科，也包括我们的社区咨询委员会的参与。我们将遵循 美国国立卫生研究院的SPORE指南进行这些审查。除了资金支持， DRP项目将获得强大的基础设施支持，并获得生物标本和与以下方面相关的专业知识： 通过我们的行政和生物标本和病理学核心（目标3）的新技术。与我们 慷慨的机构配对支持，我们将每年向DRP项目提供10万美元的资助， 预计我们每年将资助约3个为期一年的项目。所有DRP项目的进度将 定期监测其具体目标和里程碑的实现情况， 评价标准（目标4）。特别令人感兴趣的是每个项目推进到完整SPORE的潜力 项目我们还将跟踪每个项目的长期可报告成果，例如同行评审的手稿， 口头陈述和赠款资助。