Training OPportunities in Translational Imaging Education and Research (TOP-TIER)

转化成像教育和研究的培训机会（顶级）

• 批准号: 10245164
• 负责人: Samuel Achilefu
• 金额: $ 25.37万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-07 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10245164
• 关键词: Image; education research; training opportunity

PROJECT SUMMARY Precision medicine is emerging as an approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle. While some limited advances in precision medicine have been made in the field of oncology, precision medicine is not in broad practice. Precision medicine has become an initiative of the National Institutes of Health (NIH) and its partners. Development of methods of patient-specific biomarker imaging to guide and monitor patient-specific therapies will be needed to move forward this new NIH initiative. A trained physician-scientist workforce is key to taking advantage of these new developments. Precision imaging advances are interdisciplinary with technology innovations crossing the physical, computational, and biological sciences. These studies start with preclinical mechanistic inquiries using targeted pathology-based imaging and then expand into human subjects. Human studies include safety testing and the Food and Drug Administration's (FDA) Investigational New Drug (IND) and Device Exemption (IDE) process. The ultimate goal is to make research innovations widely available to the public and the entire practicing medical community through commercialization. Although this “bench-to-bedside” process has been widely acclaimed, there remains a knowledge gap in the medical imaging research community as to how to take preclinical research into humans, and how to then take these innovations to the public. Moreover, clinical scientists – residents and fellows – often lack the understanding to navigate research regulatory requirements as well as the knowledge base to understand or perform preclinical research that will inform the mechanism of innovation. A completely new educational and creative paradigm is required to better prepare future imaging scientists for the challenges of the NIH Precision Medicine Initiative. Interdisciplinary teams of physician-scientists must work together at the interfaces of biology, technology, and medicine, and physicians must be educated to work to bring innovation through the FDA regulatory processes, into human subjects and to the public through commercialization. In this application, we propose a model of education unlike any other for resident and fellow physician-scientists that will provide them with a two-year training program consisting of a) a required curriculum (year 1) that covers not only training in the ethics, regulatory and practical aspects of imaging research, but also a skill set for innovation translation, and b) dedicated translational imaging research (year 2) under the mentorship of highly-accomplished imaging pre-clinical and clinician scientists. With these needs and goals in mind, we are proposing TOP-TIER (Training OPportunities in Translational Imaging Education and Research), a clinician-scientist post-doctoral training program at Washington University (WU) in St. Louis to prepare resident and fellow trainees to bring preclinical imaging innovations into patients and to the practice of medicine.

项目概要 精准医学正在成为一种疾病治疗和预防的方法，它考虑到 考虑基因、环境和生活方式的个体差异。虽然精度方面的进步有限 医学在肿瘤学领域已经取得了进展，但精准医学尚未得到广泛实践。精确 医学已成为美国国立卫生研究院 (NIH) 及其合作伙伴的一项倡议。发展 用于指导和监测患者特异性治疗的患者特异性生物标志物成像方法将是 需要推进这项新的 NIH 举措。训练有素的医师科学家队伍是取得成功的关键 充分利用这些新发展。精密成像的进步与技术是跨学科的 跨越物理、计算和生物科学的创新。这些研究始于 使用基于病理学的靶向成像进行临床前机制调查，然后扩展到人类 科目。人体研究包括安全测试和食品和药物管理局 (FDA) 的 研究性新药 (IND) 和器械豁免 (IDE) 流程。最终目的是进行研究 通过以下方式向公众和整个执业医学界广泛提供创新 商业化。尽管这种“从实验室到临床”的过程受到了广泛好评，但仍然存在 医学影像研究界在如何将临床前研究纳入临床前研究方面存在知识差距 人类，以及如何将这些创新推向公众。此外，临床科学家——居民和 研究员——往往缺乏理解研究监管要求以及 用于理解或进行临床前研究的知识库，这些研究将为创新机制提供信息。 需要全新的教育和创造性范式来更好地为未来的成像科学家做好准备 应对 NIH 精准医学计划的挑战。跨学科的医师科学家团队 必须在生物学、技术和医学的界面上共同努力，医生必须 受过教育，致力于通过 FDA 监管流程将创新带入人类受试者并 通过商业化走向大众。在此应用程序中，我们提出了一种不同于任何其他的教育模式 为住院医生和同行医师科学家提供为期两年的培训计划，其中包括 a) 必修课程（第一年）不仅涵盖道德、监管和实践方面的培训 b) 专门的翻译 在出色的成像临床前和临床医生的指导下进行成像研究（第二年） 科学家。考虑到这些需求和目标，我们提出 TOP-TIER（以下领域的培训机会）： 转化成像教育和研究），临床医生科学家博士后培训项目 圣路易斯华盛顿大学 (WU) 准备让住院医师和实习生携带临床前成像 对患者和医学实践的创新。