Career Enhancement Core

职业提升核心

• 批准号: 10248362
• 负责人: MICHAEL J MUGAVERO
• 金额: $ 3.83万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10248362
• 关键词: Academy; Active Learning; Center for Translational Science Activities; Clinical Competence; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Communicable Diseases; Communication; Communities; Competence; Complement; Congenital herpes simplex; Contracts; Critiques; Development; Disease; Educational Activities; Eligibility Determination; Ensure; Enterovirus; Ethics; Faculty; Fostering; Foundations; Funding; Goals; Grant; Growth; Individual; Industry; Information Dissemination; Institution; Investigation; Journals; Knowledge; Leadership; Medicine; Mentors; Methodology; Neonatal; Parechovirus; Patients; Pediatric cohort; Peer Review; Perinatal Infection; Publications; Publishing; Rare Diseases; Research; Research Activity; Research Design; Research Methodology; Research Personnel; Research Project Grants; Research Training; Science; Sepsis; Simplexvirus; Training; Training Programs; Translational Research; Virus Diseases; Writing; base; career; career development; clinical center; cohort; congenital cytomegalovirus; congenital infection; experience; externship; innovation; meetings; next generation; pharmacometrics; professor; programs; recruit; research and development; sabbatical; skills; stakeholder perspectives; success; training opportunity; translational scientist

The Congenital and Perinatal Infections Consortium (CPIC) Career Enhancement Core will impact the research career development of the next generation of rare diseases researchers focusing on congenital cytomegalovirus (CMV) disease, neonatal herpes simplex virus (HSV) infection, and neonatal enterovirus (EV) and parechovirus (HPeV) sepsis. The Career Enhancement Core will promote the development of research skills and knowledge for those at all career stages in support of a diverse, innovative, and ethically rigorous research base. The overall goal of the Core is to provide didactic and experiential training in clinical and translational research in order to enhance scientific knowledge and an understanding of stakeholder perspectives unique to the rare diseases patient cohort. To develop CPIC Research Scholars, the Career Enhancement Core will: 1) identify and recruit a promising and diverse cohort of pediatric investigators for career enhancement and mentored research in rare diseases caused by congenital and perinatal infections; 2) expand the formal training of nascent investigators in research methodology, rigorous study design and scientific writing, all skills that are crucial to successful investigation and dissemination of findings in collaboration with UAB's NCATS-funded Center for Clinical and Translational Science (CCTS); and 3) stimulate experiential learning via the development of externships or “mini-sabbaticals” within the CPIC, including industry and community stakeholder partners. Externships across the CPIC will expand and foster increased collaborations and interactions between consortium institutions in a way that contributes to outstanding science and further growth of our research base. Led by Michael J. Mugavero, MD, MHSc, the Career Enhancement Oversight Committee will select fellows and early stage investigators as Research Scholars. These Scholars will receive training in a variety of skills including: 1) the regulatory and ethical requirements of research; special topics specific to rare diseases and CPIC-specific research such as pharmacometrics, 2) an understanding of stakeholder perspective and the communication of scientific results in appropriate formats for different audiences, and methodological issues related to study design and implementation; 3) core competencies of clinical and translational science, including clinical trials considerations as well as grant writing and dissemination of results; and 4) skills needed to review and critique published rare diseases research. In addition to this foundational training, Research Scholars will also receive experiential, mentored research training by Program Faculty.

先天性和围产期感染联盟（CPIC）职业提升核心将影响 下一代罕见病研究人员的研究职业发展，重点是先天性 巨细胞病毒（CMV）疾病、新生儿单纯疱疹病毒（HSV）感染和新生儿肠道病毒（EV） 和双埃柯病毒（HPeV）败血症。职业提升核心将促进研究的发展 技能和知识，为那些在所有职业阶段，以支持一个多样化的，创新的，严格的道德 研究基地。核心的总体目标是提供教学和经验培训的临床和 转化研究，以提高科学知识和利益相关者的理解 罕见病患者队列的独特视角。 为了培养CPIC研究学者，职业提升核心将：1）识别并招募有前途的人 儿科研究人员的多样化队列，以促进罕见疾病的职业发展和指导研究 先天性和围产期感染引起的; 2）扩大对新生儿调查人员的正式培训， 研究方法，严格的研究设计和科学写作，所有这些技能都是成功的关键 与UAB的NCATS资助的临床和医学中心合作， 翻译科学（CCTS）;和3）通过发展externships或 CPIC内部的“小休假”，包括行业和社区利益相关者合作伙伴。各地的实习生 CPIC将扩大和促进联盟机构之间的合作和互动， 这种方式有助于杰出的科学和我们的研究基础的进一步发展。 由Michael J. Mugavero，MD，MHSc领导，职业提升监督委员会将选择研究员 和早期研究者作为研究学者。这些学者将接受各种技能的培训 包括：1）研究的监管和伦理要求;罕见疾病的特殊主题， CPIC特定的研究，如药物计量学，2）了解利益相关者的观点和 以适当的格式向不同受众通报科学成果，以及方法问题 与研究设计和实施相关; 3）临床和转化科学的核心能力， 包括临床试验的考虑因素以及资助的撰写和结果的传播;以及4）所需的技能 对已发表的罕见疾病研究进行回顾和评论。除了这些基础训练，研究 学者们还将接受项目教师的经验，指导研究培训。