San Diego Resource Center for advancing Alzheimer's Research in Minority Seniors (ARMS)

圣地亚哥推进少数族裔老年人阿尔茨海默病研究资源中心 (ARMS)

• 批准号: 10248004
• 负责人: JOHN P. ELDER
• 金额: $ 2.72万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10248004
• 关键词: Affect; Aging; Alcohol consumption; Alcohols; Alzheimer' s Disease; Alzheimer' s disease related dementia; Anatomy; Brain; Brain imaging; Cognitive; Collaborations; Communities; Development; Doctor of Philosophy; Educational workshop; Elderly; Goals; Knowledge; Learning; Measures; Mentors; Minority; Neuroanatomy; Public Health; Reading; Research; Research Personnel; Research Project Grants; Research Training; Resources; Scientist; Series; Statistical Data Interpretation; Statistical Methods; Techniques; Thick; Training; Training Activity; Work; Writing; aging brain; alcohol effect; brain health; career; career development; drinking; neuroimaging; parent grant; research and development; substance use

Project Summary Abstract This supplement will support the candidate, PhD candidate Makaya Funk-White, to attain her long-term goal of having a career as an independent investigator focused on the intersection of Alzheimer’s disease and related dementias (ADRD) and substance use. To achieve this goal, she needs to learn more about alcohol use among older adults, and how alcohol use may affect cognitive and brain health in aging. Ms. Makaya Funk-White has identified a team of mentors to help her achieve these goals, and together, they have devised a plan of research and career development training activities that will facilitate attainment of her career goals. For this supplement, she will work with her new mentors, Drs. Emilie Reas and Linda McEvoy, on a research project that is examining whether neuroimaging measures of regional cortical thickness or volume, and measures of microstructural integrity differ by amount of alcohol drinking among healthy, community-dwelling older adults. Participating in this project will help her better understand brain anatomy, neuroimaging techniques, statistical methods, and the impact of alcohol on brain aging in older adults. She will also meet regularly with her current mentor Dr. Alison Moore and engage in a series of directed readings to further her understanding of substance use in older adults. These activities will be complimented by other research training activities such as seminars and workshops and presentations including participation in the activities of the San Diego Alzheimer’s Disease Resource Center for Minority Aging Research (ADRCMAR) and the UCSD Alzheimer’s Disease Research Center (ADRC). The parent grant is a collaboration between UCSD and SDSU to provide mentored training of underrepresented scientists in research on Alzheimer’s disease and related dementias. Ms. Funk-White is an underrepresented scientist whose research will examine the effects of alcohol use on brain aging. Moderate drinking has been suggested to protect against the development of Alzheimer’s disease, but how moderate drinking affects the brains of older adults is not well understood. In the context of this research topic, Ms. Funk- White will also learn about neuroanatomy and neuroimaging, receive training in statistical analyses and scientific writing, and will participate in training activities of the San Diego ADRCMAR as well as the UCSD ADRC to broaden her knowledge of Alzheimer’s disease.

项目摘要 该补充将支持候选人，博士候选人Makaya Funk-White，以实现她的长期 目标是作为一名独立的研究人员，专注于阿尔茨海默病和 相关性痴呆（ADRD）和物质使用。为了实现这个目标，她需要更多地了解酒精 使用酒精在老年人中的作用，以及酒精使用如何影响老年人的认知和大脑健康。 Makaya Funk-White女士已经确定了一个导师团队来帮助她实现这些目标， 他们制定了一项研究和职业发展培训活动计划，以促进实现 她的职业目标对于这一补充，她将与她的新导师，博士埃米莉·里斯和琳达 McEhrman在一个研究项目中，该项目正在研究神经成像测量区域皮层厚度是否 或体积，并且微观结构完整性的测量因健康人群中的饮酒量而不同， 社区居住的老年人。参与这个项目将帮助她更好地了解大脑解剖学， 神经成像技术，统计方法，以及酒精对老年人大脑衰老的影响。 她还将定期与她目前的导师艾莉森摩尔博士会面，并参与一系列指导性的 阅读，以进一步了解老年人的物质使用。这些活动将受到赞扬 其他研究培训活动，如研讨会、讲习班和介绍会，包括参加 圣地亚哥老年痴呆症资源中心少数民族老龄化研究的活动 （ADRCMAR）和UCSD阿尔茨海默病研究中心（ADRC）。 家长补助金是UCSD和SDSU之间的合作，提供以下方面的指导培训： 在阿尔茨海默病和相关痴呆症研究中，科学家的代表性不足。芬克·怀特女士是一位 一位代表性不足的科学家，他的研究将研究饮酒对大脑衰老的影响。中度 饮酒被认为可以防止阿尔茨海默病的发展，但如何适度 饮酒对老年人大脑的影响尚不清楚。在这个研究课题的背景下，芬克女士- 白色还将学习神经解剖学和神经影像学，接受统计分析培训， 科学写作，并将参加圣地亚哥ADRCMAR以及UCSD的培训活动 ADRC以扩大她对阿尔茨海默病的知识。