Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients

解决慢性阻塞性肺病患者持续吸烟的心理危险因素

• 批准号: 10246382
• 负责人: Amanda R Mathew
• 金额: $ 14.81万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-11-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10246382
• 关键词: Abstinence; Achievement; Address; Affect; Anhedonia; Anxiety; Area; Behavior Therapy; Behavioral; Behavioral Medicine; Buffers; Chronic Obstructive Airway Disease; Clinical; Cognitive; Combined Modality Therapy; Data; Development; Diagnosis; Disease Progression; Distress; Doctor of Philosophy; Dyspnea; Early treatment; Elements; Emotional disorder; Exercise Tolerance; Feedback; Fostering; Future; Goals; Health; Hospitalization; Hour; Human; Individual; Intervention; Interview; Knowledge; Laboratories; Lead; Measures; Medical; Mental Depression; Mentored Patient-Oriented Research Career Development Award; Mentorship; Methodology; Methods; Morbidity - disease rate; Nicotine Dependence; Nurses; Outcome; Outcome Measure; Participant; Patient Self-Report; Patients; Persons; Pharmacotherapy; Phase; Population; Preventive Medicine; Protocols documentation; Provider; Psychological Factors; Quality of life; Randomized; Randomized Controlled Trials; Regulation; Reporting; Research; Research Assistant; Research Priority; Risk Factors; Safety; Sampling; Scientist; Series; Smoke; Smoker; Smoking; Smoking Cessation Intervention; Smoking Status; Stress; Structure; Symptoms; Testing; Tobacco; Training; Treatment Efficacy; Treatment Factor; Universities; Work; anxiety sensitivity; anxiety symptoms; base; behavioral health; career; career development; cigarette smoking; clinical care; clinically significant; comorbidity; depressive symptoms; design; effective therapy; experimental study; health disparity; high risk; improved; indexing; individualized medicine; medical schools; mindfulness; mortality; multi-component intervention; multidisciplinary; novel; phase 1 designs; pilot trial; pleasure; primary outcome; professor; psychologic; pulmonary rehabilitation; recruit; respiratory; response; secondary outcome; self help; skills; smoking cessation; targeted treatment; therapy design; therapy development; treatment adherence; treatment as usual; trial design

PROJECT SUMMARY/ABSTRACT Chronic Obstructive Pulmonary Disease (COPD) is caused primarily by smoking and smoking cessation is the first-line treatment for slowing disease progression. Despite this, nearly 50% of COPD patients continue to smoke following diagnosis. Smokers with COPD report high rates of co-occurring conditions – nicotine dependence, depression, and anxiety – which serve as barriers to quitting. The proposed research will develop and pilot test a behavioral intervention designed to target the common psychological factors underlying these co-occurring conditions and foster smoking cessation among COPD patients. Primary aims of the proposed research are to: 1) Refine behavioral treatment components through qualitative interviews with patients and providers, 2) Develop a tailored behavioral treatment to address psychological risk factors among COPD patients using single case design experiments, and 3) Conduct a pilot randomized controlled trial (RCT) to examine the effects of the multi-component intervention on smoking outcome, as compared to minimally-enhanced usual care. The proposed project will be the first to adapt a behavioral treatment to specifically target psychological risk factors among COPD patients who smoke. By addressing core psychological risk factors, the behavioral treatment may help buffer against stress associated with disease progression and increase COPD patients' exercise tolerance, engagement in pulmonary rehabilitation, and quality of life. Thus, this intervention has potential to obviate a large number of health burdens among COPD patients, and ultimately to reduce morbidity and mortality associated with COPD. Amanda Mathew, PhD, a Research Assistant Professor at Northwestern University Feinberg School of Medicine, is seeking five years of support through the K23 Mentored Patient-Oriented Research Career Development Award for training and research related to development and testing of smoking cessation interventions targeted to psychological risk factors among COPD patients. Dr. Mathew's overarching career goals are to elucidate the mechanisms by which psychological factors impact cigarette smoking, develop novel interventions for smokers with medical and psychiatric comorbidities, and reduce tobacco-related health disparities. Through the proposed training plan, Dr. Mathew will expand her knowledge and skills related to intervention development; behavioral RCT design, conduct, and analysis; and smoking cessation and treatment needs specific to individuals with COPD. Dr. Mathew's multidisciplinary mentorship team has demonstrated expertise in these content areas, and is committed to Dr. Mathew's career development. Dr. Mathew's proposed work is also well-aligned with behavioral medicine research priorities within the Department of Preventive Medicine at Northwestern University Feinberg School of Medicine.

项目总结/摘要 慢性阻塞性肺疾病（COPD）主要是由吸烟和吸烟引起的 戒烟是减缓疾病进展的一线治疗。尽管如此，近50%的COPD患者 诊断后继续吸烟。患有COPD的吸烟者报告并发症的发生率很高- 尼古丁依赖、抑郁和焦虑--这些都是戒烟的障碍。拟议的研究将 制定并试点测试针对常见心理因素的行为干预措施 这些并发症的基础，并促进COPD患者戒烟。 拟议研究的主要目的是：1）通过以下方式完善行为治疗成分： 与患者和提供者的定性访谈，2）制定量身定制的行为治疗，以解决 采用单病例设计实验，对COPD患者的心理危险因素进行研究; 3）进行试点 随机对照试验（RCT），以检查多组分干预对吸烟的影响 结果，与最低限度增强的常规护理相比。拟议的项目将是第一个适应 行为治疗，专门针对吸烟的COPD患者的心理危险因素。通过 针对核心的心理风险因素，行为治疗可能有助于缓冲相关的压力， 随着疾病的进展，增加COPD患者的运动耐量， 康复和生活质量。因此，这种干预措施有可能使大量的健康 减轻COPD患者的负担，并最终降低与COPD相关的发病率和死亡率。 阿曼达马修，博士，研究助理教授在西北大学范伯格学院 医学，正在寻求通过K23指导的以患者为导向的研究生涯五年的支持 发展奖，用于与戒烟开发和测试相关的培训和研究 针对COPD患者的心理危险因素进行干预。马修博士的职业生涯 目的是阐明心理因素影响吸烟的机制， 对患有医学和精神共病的吸烟者进行干预，并减少烟草相关的健康 差距。通过拟议的培训计划，马修博士将扩大她的知识和技能， 干预开发;行为RCT设计、实施和分析;戒烟和 针对COPD患者的治疗需求。马修博士的多学科导师团队 在这些内容领域表现出专业知识，并致力于马修博士的职业发展。博士 马修提出的工作也与行为医学研究的优先事项保持一致， 西北大学范伯格医学院预防医学系。

项目成果

Assessment of Self-Management Treatment Needs Among COPD Helpline Callers.

慢性阻塞性肺病热线求助者自我管理治疗需求的评估。

• DOI: 10.1080/15412555.2019.1575350
• 发表时间: 2019
• 期刊: COPD
• 影响因子: 2.2
• 作者: Mathew,AmandaR;Guzman,Miriam;Bridges,Cherylee;Yount,Susan;Kalhan,Ravi;Hitsman,Brian
• 通讯作者: Hitsman,Brian

Practice Quit Attempts: Scoping Review of a Novel Intervention Strategy.

练习戒烟尝试：新颖干预策略的范围审查。

• DOI: 10.15288/jsad.2022.83.115
• 发表时间: 2022
• 期刊: Journal of studies on alcohol and drugs
• 影响因子: 3.4
• 作者: Cox,ChelseaM;Westrick,JenniferC;McCarthy,DanielleE;Carpenter,MatthewJ;Mathew,AmandaR
• 通讯作者: Mathew,AmandaR

Trauma exposure, PTSD symptoms, and tobacco use: Does church attendance buffer negative effects?

• DOI: 10.1002/jcop.22420
• 发表时间: 2020-09
• 期刊: Journal of community psychology
• 影响因子: 2.3
• 作者: Mathew AR;Yang E;Avery EF;Crane MM;Lange-Maia BS;Lynch EB
• 通讯作者: Lynch EB

Psychological Functioning in Patients With Chronic Obstructive Pulmonary Disease: A Preliminary Study of Relations With Smoking Status and Disease Impact.

慢性阻塞性肺疾病患者的心理功能：与吸烟状况和疾病影响关系的初步研究。

• DOI: 10.1093/ntr/nty102
• 发表时间: 2019
• 期刊: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
• 作者: Mathew,AmandaR;Yount,SusanE;Kalhan,Ravi;Hitsman,Brian
• 通讯作者: Hitsman,Brian