Optimizing self-management COPD treatment through the American Lung Association Helpline

通过美国肺脏协会帮助热线优化慢性阻塞性肺病的自我管理治疗

• 批准号: 10379319
• 负责人: Amanda R Mathew
• 金额: $ 8.45万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10379319
• 关键词: Address; American Lung Association; Behavior; Caregiver support; Caring; Chronic; Chronic Obstructive Pulmonary Disease; Clinical; Collaborations; Data; Database Management Systems; Diet; Disease Outcome; Disease Progression; Dyspnea Management; Education; Educational Curriculum; Effectiveness; Elements; Engineering; Ensure; Experimental Designs; Goals; Health; Heterogeneity; Hospitalization; Individual; Intervention; Interview; Length; Literature; Measurement; Measures; Mediating; Mediator of activation protein; Mentored Patient-Oriented Research Career Development Award; Methodology; Methods; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Outcome; Outcome Measure; Participant; Patients; Performance; Physical activity; Population; Procedures; Public Health; Quality of life; Questionnaires; Randomized; Research; Research Design; Research Personnel; Resources; Role; Sampling; Science; Self Management; Smoking Cessation Intervention; Symptoms; Telephone; Testing; Time; Training; United States; Walking; Work; acceptability and feasibility; base; behavioral health; burden of illness; chronic respiratory disease; clinically relevant; cost; design; effective therapy; experimental study; feasibility testing; follow-up; health related quality of life; improved; innovation; medical specialties; medication compliance; mortality; multiphase optimization strategy; peer support; pilot test; population health; prevent; primary outcome; programs; recruit; retention rate; rural area; screening; secondary outcome; telehealth; telephone delivery; therapy development; treatment optimization; treatment program; trial design

PROJECT SUMMARY/ ABSTRACT Chronic Obstructive Pulmonary Disease (COPD) is an increasingly prevalent and costly chronic health condition, and is the third major cause of morbidity and mortality in the United States. Self-management treatment programs for COPD are shown to improve health-related quality of life and prevent COPD-related hospitalizations. Despite their clinical benefits, these programs are typically multi-component and time- and resource-intensive. To date, no study has been conducted to isolate the role of individual self-management treatment components in contributing to improved COPD outcomes. The current application proposes to establish the feasibility of using the Multiphase Optimization Strategy (MOST) framework to optimize COPD self-management treatment delivered by the American Lung Association (ALA) Helpline. Treatment components to be evaluated include duration of self-management education, ground-based walking training, peer support, and caregiver support. The primary outcome is health-related quality of life, with secondary outcomes of COPD symptom burden, self-management behaviors, and hospitalization. Specific aims are: Aim 1. Design a factorial experiment and develop operational procedures (i.e., screening/ recruitment, randomization, and database management) for successful implementation. Aim 2. Establish feasibility and acceptability by pilot testing the study design with an initial sample of 48 individuals with COPD. Resulting values will provide estimates of recruitment and retention rates, outcome measure variability, treatment fidelity, and acceptability of treatment components to inform a subsequent fully-powered optimization trial. The proposed project will also establish the PI as one of the few researchers employing optimization methods within the field of COPD self-management. Dr. Mathew is currently completing an NHLBI K23 award (K23 HL138165) to develop and test a tailored smoking cessation intervention for individuals with COPD. The proposed R03 will extend her treatment development work to additional behavioral health targets addressed by COPD self-management treatment, such as dyspnea management, medication adherence, physical activity, and diet. Public Health Impact: The proposed study is an initial step to address a critical research gap regarding identifying effective elements of COPD self-management treatment. The long-term goal of this line of research is to optimize the effectiveness of multi-component COPD self-management interventions, and reduce COPD-related disease burden.

项目摘要/摘要 慢性阻塞性肺疾病（COPD）是一种越来越普遍且昂贵的慢性健康 状况，是美国发病率和死亡率的第三个主要原因。自我管理 证明COPD的治疗计划可改善与健康相关的生活质量并防止与COPD相关 住院。尽管它们具有临床益处，但这些程序通常是多组分和时间和时间 - 资源密集型。迄今为止，尚未进行研究以隔离个人自我管理的作用 治疗成分有助于改善COPD结果。当前申请提出 建立使用多相优化策略（大多数）框架来优化COPD的可行性 由美国肺协会（ALA）热线索引提供的自我管理治疗。治疗 要评估的组件包括自我管理教育的持续时间，地面步行培训， 同伴支持和护理人员支持。主要结果是与健康相关的生活质量，次要 COPD症状负担，自我管理行为和住院的结果。具体目的是：目标 1。设计阶乘实验并制定操作程序（即筛选/招聘， 随机化和数据库管理）用于成功实施。目标2。确定可行性和 通过试点测试研究设计的可接受性，最初是48个COPD个体的样本。结果 值将提供招聘和保留率的估计，结果度量的变异性，治疗保真度， 以及治疗成分的可接受性，以告知随后的全功率优化试验。这 拟议的项目还将建立PI作为使用优化方法的少数研究人员之一 在COPD自我管理领域。 Mathew博士目前正在完成NHLBI K23奖（K23 HL138165）为COPD患者开发和测试量身定制的戒烟干预措施。这 拟议的R03将将她的治疗开发工作扩展到其他行为健康目标。 COPD自我管理治疗，例如呼吸困难管理，药物依从性，体育活动， 和饮食。公共卫生影响：拟议的研究是解决关键研究差距的第一步 关于确定COPD自我管理处理的有效元素。这条线的长期目标 研究是为了优化多组分COPD自我管理干预措施的有效性，并 减轻与COPD相关的疾病负担。