Core E: Biostatistics & Informatics Core

核心E：生物统计学

• 批准号: 10248514
• 负责人: Dongmei Li
• 金额: $ 46.02万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-14 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10248514
• 关键词: Behavior; Bioinformatics; Biological Markers; Biometry; Cities; Clinical Sciences; DNA Methylation; Data; Data Analyses; Data Collection; Data Reporting; Database Management Systems; Databases; Development; Doctor of Philosophy; Educational workshop; Elements; Ensure; Epigenetic Process; Flavoring; Gene Expression; Genomics; Goals; Health; Health Sciences; Human; Individual; Informatics; Institutes; Institution; Lead; Longitudinal Studies; Methodology; Methods; Mus; PhenX Toolkit; Pilot Projects; Procedures; Public Health; Quality Control; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Research Training; Resources; Risk; Roswell Park Cancer Institute; Sample Size; Science; Secure; Services; Standardization; Statistical Data Interpretation; Statistical Methods; Tobacco; Training; Translational Research; Universities; analytical method; career; clinical translation; cost efficient; data exchange; data harmonization; data integrity; data management; data quality; data sharing; epidemiologic data; epigenomics; experience; genomic data; genomic tools; method development; mid-career faculty; novel; power analysis; programs; quality assurance; rapid technique; response; symposium; synergism; tobacco flavor; tobacco products; tobacco regulatory science; tool; tool development; transcriptome

The overarching goal of the Biostatistics and Informatics (BI) Core is to provide high quality and state-of-the- art services in biostatistics and informatics to all research projects and data generating cores within the WNY Center for Research on Flavored Tobacco Products (CRoFT). The BI core will provide cost-efficient and centralized service for appropriate study design, data collection, secured data transfer, data quality control, data harmonization, database management, biostatistical and bioinformatical data analysis, results interpretation and reporting, as well as novel biostatistical and bioinformatical methods and tools development, and training. The core lead Dr. Li and two core co-investigators Drs. McCall and Yan have extensive experiences in biostatistics and bioinformatics, including study design, data collection, data quality control, cross-sectional and longitudinal data analysis, DNA methylation and gene expression data analysis, novel biostatistical and bioinformatical methods and tools development. The BI core will achieve the goal through the following specific aims: Aim 1: Study design support for ongoing and pilot projects. The BI core will provide support to rapid response and career enhancement pilot projects within CRoFT to ensure appropriate research design methods and adequate sample size resulted from power analysis. In addition, the BI core will advise investigators conducting longitudinal studies on procedure for minimizing attrition and maximizing participation. Aim 2: Data capture, quality assurance and harmonization. The BI core will set up a CRoFT database to capture all data generated from projects and cores, conduct data quality control procedures to ensure the high quality of the data, and conduct data harmonization through PhenX Toolkit to facilitate the data sharing across all Tobacco Centers of Regulator Science (TCORS). Aim 3: Statistical and bioinformatical data analysis, novel methods and tools development. The BI core will standardize biostatistical and bioinformatical methods and tools for genomic data analysis, provide epidemiological data analysis for identifying risks of emerging flavoring compounds associated with human health, and develop cutting-edge novel biostatistical and bioinformatical methods and tools for integrated data analysis across projects to categorize flavor risks. Aim 4. Statistical and bioinformatical methods and tools training. The BI core will promote dissemination of the novel biostatistical and bioinformatical methods and tools to all TCORS investigators through publicly accessible seminars, symposia, and workshops. The BI core will also partner with Administrative Core (AC) and Career Enhancement Core (CEC) and leverage the resources within the University of Rochester Clinical and Translations Science Institute to provide robust and centralized support to tobacco product regulator science.

生物统计学和信息学（BI）核心的总体目标是提供高质量和最先进的 为WNY内的所有研究项目和数据生成核心提供生物统计学和信息学方面的艺术服务 Flavour Tobacco Products（CRoFT）BI核心将提供具有成本效益和 集中服务，用于适当的研究设计、数据收集、安全的数据传输、数据质量控制， 数据协调、数据库管理、生物统计学和生物信息学数据分析、结果 解释和报告，以及新的生物统计和生物信息学方法和工具的开发， 和培训及其有效核心负责人李博士和两名核心合作研究者麦考尔博士和严博士有广泛的 生物统计学和生物信息学方面的经验，包括研究设计、数据收集、数据质量控制， 横向和纵向数据分析，DNA甲基化和基因表达数据分析，新的 生物统计学和生物信息学方法和工具开发。BI核心将通过 具体目标如下： 目标1：为正在进行的试点项目提供研究设计支持。BI核心将为快速 CRoFT内的响应和职业提升试点项目，以确保适当的研究设计方法 功效分析得出样本量充足。此外，BI核心将建议研究者 就尽量减少自然减员和尽量扩大参与的程序进行纵向研究。 目标2：数据收集、质量保证和统一。BI核心将建立CRoFT数据库， 捕获项目和核心产生的所有数据，进行数据质量控制程序，以确保高质量的 数据质量，并通过PhenX Toolkit进行数据协调，以促进数据共享 烟草监管科学中心（TCORS） 目标3：统计和生物信息学数据分析，新方法和工具开发。BI核心 将标准化基因组数据分析的生物统计和生物信息方法和工具，提供 流行病学数据分析，用于识别与人类相关的新兴调味化合物的风险 健康，并为综合数据开发尖端的新生物统计和生物信息学方法和工具 跨项目分析，以分类风味风险。 目标4。统计和生物信息学方法和工具培训。BI核心将促进传播 新的生物统计学和生物信息学方法和工具，通过公开向所有TCORS研究人员 无障碍研讨会、专题讨论会和讲习班。 BI核心还将与行政核心（AC）和职业提升核心（CEC）合作， 罗切斯特大学临床和转化科学研究所内的资源， 并集中支持烟草产品调节剂科学。