Personalized Model System Core
个性化模型系统核心
基本信息
- 批准号:10249242
- 负责人:
- 金额:$ 22.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-01 至 2023-06-30
- 项目状态:已结题
- 来源:
- 关键词:Applications GrantsBiological AssayBiological ModelsBiologyCell Culture TechniquesCellsCenter Core GrantsChildhoodClinicalCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDevelopmentDiseaseDuct (organ) structureEmbryoEndodermFluid BalanceFluids and SecretionsGenotypeGoalsHeadHumanInterdisciplinary StudyInternationalIntestinesLungMedical centerMembrane ProteinsMethodsMicroscopicMicroscopyModelingMutationMyofibroblastNamesNational Institute of Diabetes and Digestive and Kidney DiseasesNoseOrganogenesisOrganoidsPancreatic ductPatientsPediatric HospitalsPhenotypePhysiologyResearchResearch PersonnelResourcesServicesSmall IntestinesTechniquesTestingTherapeuticTherapeutic StudiesTissue EngineeringTissuesTrainingTranslational Researchclinical investigationcystic fibrosis patientsgastrointestinalgastrointestinal transplantationhuman modelhuman pluripotent stem cellhuman stem cellsin vivoindividualized medicineinduced pluripotent stem cellinduced pluripotent stem cell technologyinnovationinterestintestinal epitheliumintestine surgerynovelpatient populationpersonalized medicineranpirnaserepositorysoundstem cell derived tissuesstem cellstool
项目摘要
PROJECT SUMMARY:
A key component of this P30 application is the ‘Personalized Model System Core’. The models will
include the patient-specific cultures derived from intestinal epithelia (enteroids) and the induced pluripotent
stem cells (iPSCs) from myofibroblasts. These patient specific cultures will be used to study CFTR function
and fluid homeostasis, and the information obtained will be used towards personalized treatment options.
The Personalized Model System core will develop and bank these models, develop and validate the assays
for CF/CFTR research, and distribute the resources to researchers worldwide. The long-term goal of this
core is to use models derived from the patient to facilitate his/her personalized therapy. Specific Aim 1.
Will be to provide CF patient-specific enteroids (small bowel and colonic). Specific Aim 2. Will be to
provide well-characterized CF patient-specific induced pluripotent stem cells (iPSCs)-derived tissue from
myofibroblasts. Specific Aim 3. Will provide assay services and training to local, national and international
investigators interested in personalized model system to study the functional involvement of CFTR fluid
secretion in intestinal enteroids, spheroids and organoids.
The Core will create resources and sound services that have important long term clinical
implications toward patient-specific therapies for cystic fibrosis. The core will provide training in a variety of
state-of-art and innovative techniques including the development of intestinal stem cells cultures, iPSCs
technology, high content microscopy, to name a few, to researchers who will be able to use these
techniques to study not only CF/CFTR biology but other membrane proteins and their associated diseases.
项目总结:
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Anjaparavanda P Naren其他文献
Anjaparavanda P Naren的其他文献
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{{ truncateString('Anjaparavanda P Naren', 18)}}的其他基金
Investigating of the Mechanisms of Action of CFTR Correctors in RescuingDelta F508-CFTR
CFTR校正器在拯救Delta F508-CFTR中的作用机制研究
- 批准号:
10406127 - 财政年份:2020
- 资助金额:
$ 22.63万 - 项目类别:
Investigating of the Mechanisms of Action of CFTR Correctors in RescuingDelta F508-CFTR
CFTR校正器在拯救Delta F508-CFTR中的作用机制研究
- 批准号:
10454293 - 财政年份:2020
- 资助金额:
$ 22.63万 - 项目类别:
Investigating of the Mechanisms of Action of CFTR Correctors in RescuingDelta F508-CFTR
CFTR校正器在拯救Delta F508-CFTR中的作用机制研究
- 批准号:
10656430 - 财政年份:2020
- 资助金额:
$ 22.63万 - 项目类别:
Personalized Cystic Fibrosis Therapy and Research Center
个性化囊性纤维化治疗和研究中心
- 批准号:
10672704 - 财政年份:2018
- 资助金额:
$ 22.63万 - 项目类别:
Human Enteroids, Colonoids, and iPSC derived HIO's to study CFTR-relatedDisorders
人类肠样、结肠样和 iPSC 衍生的 HIO 用于研究 CFTR 相关疾病
- 批准号:
9551790 - 财政年份:2017
- 资助金额:
$ 22.63万 - 项目类别:
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