Center for the Assessment of the Public Health Impact of Tobacco Regulations

项目摘要 烟草法规公共卫生影响评估中心旨在提供证据- 烟草法规对行为和公共健康影响的基于专家的建模。的 中心的主要科学领域是影响分析和健康影响。 为了评估烟草使用和管制对公共健康的影响，必须从以下方面收集信息： 使用行为、健康风险和法规对使用模式的影响的不同来源。这些信息 然后必须以系统和客观的方式进行综合和处理，帮助决策者衡量 这些条例将在人口一级产生的影响，并帮助他们作出决策 过程烟草使用模式和相关健康结果的模拟模型可以作为 帮助FDA评估和预测以下因素导致的人群水平获益和危害的关键工具： 有关新的和现有烟草产品的监管政策。如果应用得当，建模还 成为一种组织和综合不同信息来源并确定其中差距的方式 在烟草使用模式因不同人群而异的情况下，尤其如此。 我们的中心将有三个项目，基于对美国历史上烟草使用模式的详细分析， 建立了四个烟草模拟模型。项目1（影响分析、卫生、 影响）是对烟草法规和政策的影响进行比较建模分析， 吸烟和电子烟的使用以及相关的长期健康结果，包括心脏、肺部疾病和 妇幼保健。项目2（影响分析、成瘾）将扩展之前开发的两个项目，并且效果良好- 建立模型，以检查管制燃烧烟草中尼古丁的可能后果 产品，但模型将是一般性的，足以考虑其他政策，影响产品的内容， 香烟，如特定的有毒物质。项目3（影响分析，行为）将建立与烟草有关的健康模型 与使用混合烟草相关的差异，并调查潜在的政策选择如何影响 多烟草使用和下游TRHDs。四个核心将为中心服务。行政核心（AC）将 协调项目和核心的工作;职业提升核心（CEC）将为初级 研究人员对烟草模拟的能力和局限性;数据分析和传播 (DAD)核心将分析和提供每个模型的数据，并开发基础设施， 传播模型参数和建模结果;研究评估和投入开发 （RAID）核心将通过以下方式生成关键策略和健康影响建模参数的参数估计值： 系统评价和荟萃分析，以及在没有足够数据时的专家小组。

Project Summary Abstract The Center for the Assessment of the Public Health Impact of Tobacco Regulations aims to provide evidence- based and expert-informed modeling of the behavioral and public health impacts of tobacco regulations. The Center’s primary scientific domains are Impact Analysis and Health Effects. To evaluate the public health impacts of tobacco use and regulation, information must be gathered from different sources on use behaviors, health risks and the impact of regulations on use patterns. This information must then be synthetized and processed in a systematic and objective manner, helping policy makers to gauge the impact that such regulations would have at the population level and aiding them in their decision-making process. Simulation modeling of tobacco use patterns and related health outcomes can serve as a one of the key tools to assist FDA in evaluating and predicting population-level benefits and harms resulting from regulatory policies pertaining to new and existing tobacco products. When well applied, modeling also becomes a way of organizing and synthesizing different sources of information and determining gaps in that information, especially in situations where tobacco use patterns vary for different populations. Our Center will have three projects based on detailed analysis of historical tobacco use patterns in the US and using four established tobacco simulation models. The overarching aim of Project 1 (Impact Analysis, Health Effects) is to conduct comparative modeling analyses of the impact of tobacco regulations and policies on smoking and e-cigarettes use and related long-term health outcomes, including heart, pulmonary disease and maternal and child health. Project 2 (Impact Analysis, Addiction) will extend two previously developed and well- established models to examine the possible consequences of regulating nicotine in combusted tobacco products, but the models will be general enough to consider other policies that affect the product content of cigarettes, such as specific toxicants. Project 3 (Impact Analysis, Behavior) will model tobacco-related health disparities associated with polytobacco use, and to investigate how potential policy options may impact polytobacco use and downstream TRHDs. Four cores will serve the Center. An Administrative Core (AC) will coordinate the work of the projects and cores; a Career Enhancement Core (CEC) will provide training to junior investigators on the capabilities and limitations of tobacco simulation; a Data Analysis and Dissemination (DAD) Core will analyze and provide the data for each of the models and develop infrastructure for dissemination of model parameters and modeling results; Research Assessment and Input Development (RAID) Core will generate parameter estimates for key policy and health effects modeling parameters via systematic reviews and meta-analyses, and expert panels when sufficient data are not yet available.