NK cells as the missing link between anti-cancer chemotherapy and CD8 T cell responses

细胞毒性化疗是大多数肿瘤的标准治疗方法，但很少能治愈。免疫系统具有摧毁恶性细胞的能力，但肿瘤通常逃避免疫破坏。化学免疫疗法的结合可能会改变这一点。化疗导致肿瘤细胞的DNA损伤，诱导一系列激活自然杀伤细胞的分子表达。然后，这些细胞可以激活抗肿瘤T细胞。加强这一途径的治疗可能会产生持续的抗肿瘤效果。

Cytotoxic chemotherapy is the standard of care for most tumors but it rarely cures. The immune system has the capacity to destroy malignant cells but tumors usually evade immune destruction. Combination of chemo- immunotherapy may change this. DNA damage in tumor cells, caused by chemotherapy, induces expression of a set of molecules that activate Natural Killer cells. These cells can then activate anti-tumor T cells. Therapies that enhance this pathway may induce sustained anti-tumor effects.