NK cells as the missing link between anti-cancer chemotherapy and CD8 T cell responses

NK 细胞是抗癌化疗和 CD8 T 细胞反应之间缺失的环节

• 批准号: nhmrc : 513804
• 负责人: A/Pr Anthony Scalzo
• 金额: $ 32.57万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nk-cells-missing-cell-responses/78162
• 关键词: NK; cells; missing; link; between

Cytotoxic chemotherapy is the standard of care for most tumors but it rarely cures. The immune system has the capacity to destroy malignant cells but tumors usually evade immune destruction. Combination of chemo- immunotherapy may change this. DNA damage in tumor cells, caused by chemotherapy, induces expression of a set of molecules that activate Natural Killer cells. These cells can then activate anti-tumor T cells. Therapies that enhance this pathway may induce sustained anti-tumor effects.

细胞毒性化疗是大多数肿瘤的标准治疗方法，但很少治愈。免疫系统具有破坏恶性细胞的能力，但肿瘤通常逃避免疫破坏。联合化疗和免疫治疗可能会改变这种情况.由化疗引起的肿瘤细胞中的DNA损伤诱导一组激活自然杀伤细胞的分子的表达。然后这些细胞可以激活抗肿瘤T细胞。增强这一途径的治疗可能会诱导持续的抗肿瘤作用。