Long-lived CD8 T cell responses induced by a recombinant cytomegalovirus vector

重组巨细胞病毒载体诱导的长寿命 CD8 T 细胞反应

• 批准号: nhmrc : 254636
• 负责人: A/Pr Anthony Scalzo
• 金额: $ 15.65万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/long-lived-cd8-cytomegalovirus-vector/98115
• 关键词: Long; lived; CD8; cell; responses

The priming of the immune system to protect against infection and disease is an important means to alleviate these conditions. Current vaccination technologies often rely on multiple inoculations (prime-boosting). In addition, specific priming of the immune system against pathogens that target mucosal sites has been difficult and often lacks efficacy resulting in temporary or variable protection. Using a well developed mouse model for a common human virus, we have explored the potential of this agent as a vaccine agent, making use of its long term persistence in the infected host to provide continued antigenic stimulation of the immune system. We have found that very strong and long lasting responses can be elicited after a single inoculation of avirulent virus. In this study, this effect will be further explored and developed.

启动免疫系统以预防感染和疾病是缓解这些疾病的重要手段。当前的疫苗接种技术通常依赖于多次接种（初免加强）。此外，针对粘膜部位的病原体的免疫系统的特异性启动一直很困难，并且通常缺乏效力，导致暂时或可变的保护。使用针对常见人类病毒的良好开发的小鼠模型，我们探索了该试剂作为疫苗试剂的潜力，利用其在受感染宿主中的长期持续存在来为免疫系统提供持续的抗原刺激。我们发现单次接种无毒病毒后可以引发非常强烈且持久的反应。本研究将进一步探讨和发展这种效应。