THE ROLE OF MONOCYTIC LINEAGE CELLS IN MODELS OF CORNEAL DISEASE

单核细胞谱系细胞在角膜疾病模型中的作用

• 批准号: nhmrc : 572709
• 负责人: A/Pr Anthony Scalzo
• 金额: $ 20.78万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-monocytic-lineage-corneal-disease/98408
• 关键词: ROLE; MONOCYTIC; LINEAGE; CELLS; MODELS

Vision relies on sharp, focused undistorted images passing through the cornea, the clear 'window' at the front of the eye. Corneal disease causes over 5 million cases of blindness worldwide. In patients who damage the delicate covering of the cornea, due to trauma or contact lens wear, there is an increased risk of infection that may lead to blindness. This project will study the ways in which immune cells in the cornea detect invasion by potential pathogens.

视觉依赖于通过角膜的清晰、聚焦、不失真的图像，角膜是眼睛前部清晰的“窗口”。角膜疾病导致全世界超过500万例失明。由于外伤或配戴隐形透镜，角膜脆弱的覆盖层受损的患者，感染的风险增加，可能导致失明。该项目将研究角膜中的免疫细胞检测潜在病原体入侵的方式。