Puerto Rico Biobank

波多黎各生物银行

• 批准号: 10249956
• 负责人: IDHALIZ FLORES
• 金额: $ 29.96万
• 依托单位: PONCE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-25 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10249956
• 关键词: Address; Admixture; African; Amerindian; Biocompatible Materials; Biological; Biological Specimen Banks; Blood; Cancer Biology; Cancer Center; Cancer Patient; Cancer Prognosis; Clinic; Clinical; Clinical Data; Clinics and Hospitals; Collaborations; Collection; Communities; Community Outreach; Computerized Medical Record; Consent; Consultations; Core Facility; DNA; Data; Databases; Diagnosis; Documentation; Educational Activities; Ensure; Environment; Equipment and supply inventories; Ethnic Origin; European; Event; Florida; Formalin; Fostering; Freezing; Funding; Genes; Genetic; Genome; Genomic DNA; Genomics; Geographic Locations; Goals; Grant; Health Sciences; Hispanics; Hospitals; Human; Image; Individual; Individual Differences; Informatics; Infrastructure; Institution; Island; Knowledge; Laboratories; Latino; Life Style; Malignant Neoplasms; Medical Students; Minority Groups; Molecular; Mutation; Names; Oncologist; Paraffin; Paraffin Embedding; Pathologic; Pathology; Patients; Plasma; Population; Population Heterogeneity; Precision Medicine Initiative; Predisposition; Process; Puerto Rican; Puerto Rico; RNA; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Risk Factors; Sampling; Scanning; Science; Serum; Slide; Solid; Students; System; Time; Tissue Microarray; Tissue Procurements; Tissues; Training; Translational Research; Tumor Tissue; Tumor-Derived; Underrepresented Populations; Universities; Work; anticancer research; base; biobank; cancer health disparity; clinical risk; data harmonization; data quality; design; disorder risk; education research; electronic data; epidemiologic data; ethnic minority population; gene environment interaction; health disparity; improved; neoplasm registry; outreach; personalized medicine; precision medicine; precision oncology; quality assurance; racial minority; recruit; repository; risk prediction; student training; translational cancer research; treatment response; treatment strategy; trend; tumor

PROJECT SUMMARY/ABSTRACT In order to move closer to achieving the goals of precision medicine and individualized cancer care, participation in biobanking from large numbers of individuals representing all ethnicities is essential. The scarcity of tissues available at existing biobanks from racial and ethnic minorities poses a substantial constraint to conducting research needed to understand the biological basis of health disparities. Because cancer- causing genetic alterations vary across individuals and ethnicities, the practice of precision medicine requires knowledge acquired through the study of tumor tissue derived from individuals representing diverse populations. It is important to recognize that Hispanic/Latino (H/L) ethnicity is an admixture of European, African, and Amerindians ancestral genomes, the proportions of which vary widely across individuals from different geographical regions. Also, there are differences in cancer trends associated to cancer biology and admixture genetics among different H/L sub-populations. Despite being a large proportion of the ethnic minorities living in the US, to date, there has been no comprehensive availability of tumor tissue from H/L cancer patients in national biobanks. To address this disparity, we propose to continue to develop the existing research infrastructure of the Puerto Rico Biobank (PRBB) to support research initiatives designed to understand the biological basis of cancer health disparities. The purpose of the PRBB is to facilitate the optimal collection, processing, storage, and distribution of well-annotated human biospecimens derived from the island’s H/L population for use in investigator-initiated translational cancer research. Throughout the past 10 years, a solid infrastructure has been put in place to develop this unique biorepository in Puerto Rico. Through this resource, fresh frozen tissues, paraffin blocks, high-quality tumor-derived RNA, genomic DNA, and clinical and risk factor information are available to support research at both institutions focusing on molecular aspects and determinants of cancer health disparities involving H/L living in Florida and Puerto Rico. We propose to expand the existing Partnership’s biobank via three Specific Aims. In Aim 1 we propose to continue the collection, processing, storage, and distribution of biospecimens in collaboration with local hospitals and clinics. In cooperation with the Partnership’s Outreach Core, efforts to consent healthy individuals during community outreach educational activities will continue. In Aim 2, we propose to extend the documentation of demographic, clinical, pathological, and molecular data (‘omic’, ancestry, next-gen sequence data) in collaboration with the Quantitative Sciences Core. In Aim 3, we propose to foster new collaborative research projects focused on cancer research. As facilitator of translational research, the PRBB is placed at the forefront of the Precision Medicine initiative programmatic goals of improving disease risk prediction and developing diagnosis and treatment strategies based on individual differences in genes, lifestyle, and environment, focusing on a population that is under-represented in biobanks and research.

项目概要/摘要 为了更接近实现精准医疗和个体化癌症护理的目标， 代表所有种族的大量个人参与生物样本库至关重要。这 现有生物库中来自少数种族和族裔的可用组织的稀缺构成了重大限制 开展了解健康差异的生物学基础所需的研究。因为癌症—— 造成基因改变的因素因个体和种族而异，精准医学的实践需要 通过研究来自代表不同个体的肿瘤组织而获得的知识 人口。重要的是要认识到西班牙裔/拉丁裔 (H/L) 种族是欧洲、 非洲人和美洲印第安人的祖先基因组，其比例在不同种族的个体之间差异很大 不同的地理区域。此外，与癌症生物学相关的癌症趋势也存在差异 不同 H/L 亚群之间的混合遗传学。尽管在少数民族中占很大比例 居住在美国的少数族裔，迄今为止，还没有从 H/L 中全面获得肿瘤组织 国家生物库中的癌症患者。为了解决这一差距，我们建议继续发展现有的 波多黎各生物银行 (PRBB) 的研究基础设施，用于支持旨在 了解癌症健康差异的生物学基础。 PRBB 的目的是促进最优 收集、处理、储存和分发来自生物样本的注释良好的人类生物样本 岛的 H/L 人群用于研究者发起的转化癌症研究。纵观过去10年 多年来，坚实的基础设施已经到位，以在波多黎各开发这个独特的生物样本库。通过 该资源、新鲜冷冻组织、石蜡块、高质量肿瘤来源的 RNA、基因组 DNA 和临床 和风险因素信息可支持两个机构专注于分子方面的研究 以及涉及居住在佛罗里达州和波多黎各的 H/L 的癌症健康差异的决定因素。 我们建议通过三个具体目标扩大现有合作伙伴关系的生物库。在目标 1 中，我们建议 继续与当地合作收集、处理、储存和分发生物样本 医院和诊所。与伙伴关系的外展核心合作，努力同意健康 个人在社区外展教育活动期间将继续进行。在目标 2 中，我们建议延长 人口统计、临床、病理和分子数据（“组学”、祖先、下一代序列）的记录 数据）与定量科学核心合作。在目标 3 中，我们建议促进新的协作 研究项目专注于癌症研究。作为转化研究的推动者，PRBB 被置于 精准医学倡议的前沿计划目标是改善疾病风险预测和 根据基因、生活方式等个体差异制定诊断和治疗策略 环境，重点关注生物库和研究中代表性不足的人群。