Puerto Rico BioBank Core

波多黎各生物银行核心

• 批准号: 10761652
• 负责人: IDHALIZ FLORES
• 金额: $ 14.46万
• 依托单位: PONCE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-25 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10761652
• 关键词: Acceleration; Address; Awareness; Blood; Breast; Breast Cancer Genetics; Cancer Center; Caribbean region; Clinical; Clinical Data; Clinical Trials; Collaborations; Colon; Colorectal Cancer; Communities; Community Health; Community Health Education; Community Outreach; Consent; DNA; Data; Data Set; Databases; Dedications; Demographic Survey; Development; Education; Education and Outreach; Funding; Future; Genetic; Genome; Grant; Gynecologist; Health Disparities Research; Health Educators; Health Sciences; Historical Survey; Hospitals; Individual; International; Island; Latin America; Latin American; Latino; Logistics; Lung; Malignant Neoplasms; Malignant neoplasm of ovary; Malignant neoplasm of prostate; Medical Students; Minority Participation; Molecular; Molecular Profiling; Oncologist; Organoids; Ovarian; Patient Education; Patient Recruitments; Patient Selection; Patients; Physicians; Physicians' Offices; Play; Population; Prevalence; Principal Investigator; Process; Prostate; Publications; Puerto Rican; Puerto Rico; RNA; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Role; Science; Services; Specimen; Surgeon; System; Techniques; Tissue Donations; Tissue Microarray; Tissues; Training; Translation Initiation; Underrepresented Minority; Universities; Urologist; anticancer research; biobank; breast cancer genomics; cancer diagnosis; cancer health disparity; cancer therapy; cancer type; data registry; education research; health disparity; improved; innovation; malignant breast neoplasm; medical schools; molecular phenotype; neoplasm registry; novel; outreach; patient derived xenograft model; precision medicine; recruit; targeted treatment; transcriptome sequencing; translational cancer research

ABSTRACT The Puerto Rico BioBank (PRBB) Shared Resource of the Ponce Health Sciences University-Moffitt Cancer Center (PHSU-MCC) Partnership collects, processes, annotates, stores, and distributes biospecimens and clinical-demographic data for investigator-initiated translational cancer research. As of August 2022, the PRBB has consented 4,097 subjects representing 42 different cancer types and healthy individuals. From these subjects, 1,899 clinical history and demographic surveys were completed and 8,453 biospecimens were collected. Tissues, derivative analytes (e.g., DNA/RNA), data, and tissue microarrays have been distributed to research projects supporting publications and grant submissions. The PRBB contributed to the development of a Biobanking clerkship for medical students in collaboration with the Research Education Core (REC) and contributed to education efforts in H/L communities in both Tampa and Ponce in collaboration with the Outreach Core (OC). Together with the Quantitative Sciences Core (QSC), the PRBB has consented 142 H/L patients to the ORIEN-Avatar network (https://www.oriencancer.org) improving the representation of H/L tissues in this network, dedicated to accelerating the discovery of novel targeted cancer treatments, that is currently only 7.2%. The PRBB participates in international consortia including REBLAC (Latin American and Caribbean Biobanking network), PRACTICAL (Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome), LAGENO-BC (Latin America Genomics of Breast Cancer Consortium), the Latino Colorectal Cancer Consortium (LC3), the Confluence Project for Breast Cancer Genetics. The objective of the PRBB is to address the critical unmet need in cancer health disparities of a lack of representation of H/L patients in comprehensive molecular datasets at levels that align with the prevalence of cancer in this population. The aims are: 1) Support research projects by targeted recruitment of patients of selected cancer types along with non-cancer controls. Recruitment is both broad to build a comprehensive database for future projects and focused on the currently proposed full research projects in prostate and ovarian cancer. We will continue to optimize the logistics of patient education and consenting at collaborating physician’s offices and San Lucas Hospital (SLH) and by maintaining constant contact with Project PIs. 2) Support research by developing innovative resources and services. We will focus on developing new research resources and services that can be rapidly accessed by researchers. This includes building well-annotated tissue microarrays representing cancer types that significantly impact H/Ls (prostate, ovarian), expanding molecular phenotyping (exomeSeq, RNAseq, ancestry) in collaboration with ORIEN, tapping into the potential for identifying clinical trials that are matched to a patient’s molecular profile, and leverage our emerging expertise in organoid and patient-derived xenografts models to support projects. 3) Collaborate with partnership components in education, outreach, and community education on the importance of tissue donation, and improving data availability with the QSC.

抽象的 庞塞健康科学大学莫菲特癌症中心的波多黎各生物库 (PRBB) 共享资源 中心 (PHSU-MCC) 合作伙伴收集、处理、注释、存储和分发生物样本和 研究者发起的转化癌症研究的临床人口统计数据。自 2022 年 8 月起，PRBB 已获得代表 42 种不同癌症类型的 4,097 名受试者和健康个体的同意。从这些 完成了 1,899 份临床病史和人口统计调查，并采集了 8,453 份生物样本 集。组织、衍生分析物（例如 DNA/RNA）、数据和组织微阵列已分发给 支持出版物和拨款申请的研究项目。 PRBB 促进了 与研究教育核心 (REC) 合作为医学生提供生物样本库实习 与 Outreach 合作，为坦帕和庞塞的 H/L 社区的教育工作做出贡献 核心（OC）。 PRBB 与定量科学核心 (QSC) 一起同意 142 名 H/L 患者 ORIEN-Avatar 网络 (https://www.oriencancer.org) 改善了 H/L 组织的代表性 致力于加速发现新型靶向癌症治疗方法的网络，目前仅占 7.2%。 PRBB 参加了包括 REBLAC（拉丁美洲和加勒比生物银行）在内的国际联盟 网络），实用（前列腺癌协会小组调查癌症相关改变 Genome）、LAGENO-BC（拉丁美洲乳腺癌基因组学联盟）、拉丁裔结直肠癌 联盟 (LC3)，乳腺癌遗传学融合项目。 PRBB 的目标是解决 由于缺乏 H/L 患者的综合代表性，癌症健康差异中的关键未满足需求 分子数据集的水平与该人群中癌症的患病率相符。目标是： 1) 支持 通过有针对性地招募选定癌症类型的患者以及非癌症对照患者来开展研究项目。 招聘范围广泛，旨在为未来的项目建立全面的数据库，并专注于当前的项目 提出了前列腺癌和卵巢癌的完整研究项目。我们将继续优化患者物流 在合作医生办公室和圣卢卡斯医院 (SLH) 进行教育和同意，并通过维护 与项目 PI 保持持续联系。 2) 通过开发创新资源和服务来支持研究。我们将 专注于开发研究人员可以快速访问的新研究资源和服务。这 包括构建代表显着影响 H/L 的癌症类型的注释良好的组织微阵列 （前列腺、卵巢），与合作扩展分子表型分析（exomeSeq、RNAseq、ancestry） ORIEN，挖掘识别与患者分子特征相匹配的临床试验的潜力， 并利用我们在类器官和患者来源的异种移植模型方面新兴的专业知识来支持项目。 3） 与教育、外展和社区教育领域的合作伙伴就重要性进行合作 组织捐赠，并通过 QSC 提高数据可用性。