Puerto Rico BioBank Core

波多黎各生物银行核心

• 批准号: 10761652
• 负责人: IDHALIZ FLORES
• 金额: $ 14.46万
• 依托单位: PONCE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-25 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10761652
• 关键词: Acceleration; Address; Awareness; Blood; Breast; Breast Cancer Genetics; Cancer Center; Caribbean region; Clinical; Clinical Data; Clinical Trials; Collaborations; Colon; Colorectal Cancer; Communities; Community Health; Community Health Education; Community Outreach; Consent; DNA; Data; Data Set; Databases; Dedications; Demographic Survey; Development; Education; Education and Outreach; Funding; Future; Genetic; Genome; Grant; Gynecologist; Health Disparities Research; Health Educators; Health Sciences; Historical Survey; Hospitals; Individual; International; Island; Latin America; Latin American; Latino; Logistics; Lung; Malignant Neoplasms; Malignant neoplasm of ovary; Malignant neoplasm of prostate; Medical Students; Minority Participation; Molecular; Molecular Profiling; Oncologist; Organoids; Ovarian; Patient Education; Patient Recruitments; Patient Selection; Patients; Physicians; Physicians' Offices; Play; Population; Prevalence; Principal Investigator; Process; Prostate; Publications; Puerto Rican; Puerto Rico; RNA; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Role; Science; Services; Specimen; Surgeon; System; Techniques; Tissue Donations; Tissue Microarray; Tissues; Training; Translation Initiation; Underrepresented Minority; Universities; Urologist; anticancer research; biobank; breast cancer genomics; cancer diagnosis; cancer health disparity; cancer therapy; cancer type; data registry; education research; health disparity; improved; innovation; malignant breast neoplasm; medical schools; molecular phenotype; neoplasm registry; novel; outreach; patient derived xenograft model; precision medicine; recruit; targeted treatment; transcriptome sequencing; translational cancer research

ABSTRACT The Puerto Rico BioBank (PRBB) Shared Resource of the Ponce Health Sciences University-Moffitt Cancer Center (PHSU-MCC) Partnership collects, processes, annotates, stores, and distributes biospecimens and clinical-demographic data for investigator-initiated translational cancer research. As of August 2022, the PRBB has consented 4,097 subjects representing 42 different cancer types and healthy individuals. From these subjects, 1,899 clinical history and demographic surveys were completed and 8,453 biospecimens were collected. Tissues, derivative analytes (e.g., DNA/RNA), data, and tissue microarrays have been distributed to research projects supporting publications and grant submissions. The PRBB contributed to the development of a Biobanking clerkship for medical students in collaboration with the Research Education Core (REC) and contributed to education efforts in H/L communities in both Tampa and Ponce in collaboration with the Outreach Core (OC). Together with the Quantitative Sciences Core (QSC), the PRBB has consented 142 H/L patients to the ORIEN-Avatar network (https://www.oriencancer.org) improving the representation of H/L tissues in this network, dedicated to accelerating the discovery of novel targeted cancer treatments, that is currently only 7.2%. The PRBB participates in international consortia including REBLAC (Latin American and Caribbean Biobanking network), PRACTICAL (Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome), LAGENO-BC (Latin America Genomics of Breast Cancer Consortium), the Latino Colorectal Cancer Consortium (LC3), the Confluence Project for Breast Cancer Genetics. The objective of the PRBB is to address the critical unmet need in cancer health disparities of a lack of representation of H/L patients in comprehensive molecular datasets at levels that align with the prevalence of cancer in this population. The aims are: 1) Support research projects by targeted recruitment of patients of selected cancer types along with non-cancer controls. Recruitment is both broad to build a comprehensive database for future projects and focused on the currently proposed full research projects in prostate and ovarian cancer. We will continue to optimize the logistics of patient education and consenting at collaborating physician’s offices and San Lucas Hospital (SLH) and by maintaining constant contact with Project PIs. 2) Support research by developing innovative resources and services. We will focus on developing new research resources and services that can be rapidly accessed by researchers. This includes building well-annotated tissue microarrays representing cancer types that significantly impact H/Ls (prostate, ovarian), expanding molecular phenotyping (exomeSeq, RNAseq, ancestry) in collaboration with ORIEN, tapping into the potential for identifying clinical trials that are matched to a patient’s molecular profile, and leverage our emerging expertise in organoid and patient-derived xenografts models to support projects. 3) Collaborate with partnership components in education, outreach, and community education on the importance of tissue donation, and improving data availability with the QSC.

抽象的 波多黎各生物银行（PRBB）共享庞塞健康科学大学 - 莫菲特癌的共享资源 中心（PHSU-MCC）合作伙伴关系收集，流程，注释，商店和分发生物测量和分发 研究人员引起的转化癌症研究的临床人口统计数据。截至2022年8月，PRBB 已同意4,097名，代表42种不同的癌症类型和健康个体。从这些 受试者完成了1,899个临床病史和人口调查，并完成了8,453次生物测量。 集。组织，衍生分析物（例如DNA/RNA），数据和组织微阵列已分布到 研究项目支持出版物并授予提交。 PRBB为发展做出了贡献 与研究教育核心合作（REC）和 在坦帕和庞塞的H/L社区中为教育工作做出了贡献 核心（OC）。与定量科学核心（QSC）一起，PRBB同意142 h/L患者 Orien-Avatar网络（https://www.oriencancer.org）改善了H/L组织的表示 网络，致力于加速新的靶向癌症治疗，目前只有7.2％。 PRBB参加包括Reblac在内的国际财团（拉丁美洲和加勒比海生物库 网络），实用（前列腺癌协会组，研究癌症关联的变化 基因组），Lageno-BC（拉丁美洲乳腺癌财团的拉丁美洲基因组学），拉丁裔大肠癌 财团（LC3），乳腺癌遗传学的汇合项目。 PRBB的目的是解决 综合性H/L患者缺乏代表性的癌症健康分布的关键需求 与该人群中癌症患病率一致的水平的分子数据集。目的是：1）支持 通过针对选定癌症类型的患者以及非癌症对照的患者进行研究项目。 招聘既广泛地为未来的项目建立全面的数据库，又关注当前的数据库 提出了前列腺和卵巢癌的完整研究项目。我们将继续优化患者的登录 在合作医师办公室和圣卢卡斯医院（SLH）的教育和同意，并维护 与项目PIS的持续联系。 2）通过开发创新的资源和服务来支持研究。我们将 专注于开发研究人员可以快速访问的新研究资源和服务。这 包括构建代表明显影响H/LS的癌症类型的良好的组织微阵列 （前列腺，卵巢），扩展分子表型（Exomeseq，rnaseq，祖先）与 Orien，利用了与患者的分子特征相匹配的临床试验的潜力， 并利用我们在器官和患者衍生的Xenography模型中的新兴专业知识来支持项目。 3） 与教育，外展和社区教育方面的伙伴关系组成部分合作就重要性 捐赠组织捐赠，并通过QSC提高数据可用性。