Transition from Acute to Chronic Pain After Thoracic Surgery
胸外科手术后从急性疼痛转变为慢性疼痛
基本信息
- 批准号:10254680
- 负责人:
- 金额:$ 123.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-30 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAmendmentAnxietyBiological MarkersBlood Specimen CollectionBlood specimenBlue CrossBlue ShieldBudgetsCardiovascular systemCaringCellular PhoneChestChildChronicClinicalClinical TrialsComplementDataData ElementDevelopmentDiagnosticEnsureEsophagusExcisionFacultyFailureFatigueFundingGenomicsGoalsHealth StatusHealthcare SystemsHospitalsIncidenceIndividualLeadLeadershipLongitudinal StudiesLow Back PainLungMeasuresMichiganNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institute of Diabetes and Digestive and Kidney DiseasesOnline SystemsOperative Surgical ProceduresOpioidOutcomePainPain ResearchParticipantPathway interactionsPatient CarePatient Outcomes AssessmentsPatientsPerioperativePhenotypePlayPopulationPostoperative PainPostoperative PeriodPreventionProceduresProspective StudiesProteomicsProtocols documentationProviderResearchResearch DesignResolutionRisk FactorsRoleSample SizeSamplingScienceSensorySocietiesSurgeonTestingThoracic Surgical ProceduresThoracotomyTimeUnited States National Institutes of HealthUniversitiesWorkbiomarker selectionchronic painchronic pelvic painclinical centerclinical paincohortdesignexperiencehigh riskhip replacement arthroplastyknee replacement arthroplastymetabolomicsneuroimagingnovelpain processingpain symptompopulation basedprescription opioidprogramsreconstructionrecruitrheumatologistrisk variantsuccess
项目摘要
PROJECT SUMMARY / ABSTRACT
Chronic post-surgical pain (CPSP) is a major cause of new chronic pain, occurring between 10 - 40% after
common surgical procedures. Thoracic surgery procedures have among the highest rates of chronic post-
surgical pain (CPSP), with roughly 30 - 47% of patients developing new chronic pain within 6 months of
surgery. While the high incidence of CPSP following thoracic surgery is well-described, the patient- and care-
factors associated with the development of CPSP are still not clear. Some factors such as anxiety have been
described; however, most cohorts lack the sample size to assess potentially important factors, including
neuroimaging, quantitative sensory testing, and blood samples for genomics, metabolomics and proteomics.
We believe that thoracic surgery is an ideal second surgical population to add to the Acute to Chronic Pain
Signatures (A2CPS) program, complementing the first MCC population of knee arthroplasty, which has much
lower rates of new CPSP but is a better cohort to identify risk factors for failure to resolve chronic pain. Our
inter-disciplinary team from the proposed University of Michigan A2CP Multisite Clinical Center (MCC) has
unparalleled expertise to examine the phenotypic and genotypic risk factors for the development of CPSP
among patients undergoing thoracic surgery. Our PIs include an anesthesiologist, two surgeons, and a
rheumatologist that have successfully collaborated in ongoing work, and partner within a statewide network of
hospitals performing thoracotomy procedures, the Michigan Society of Thoracic and Cardiovascular
Surgeons (MSTCVS) Quality Collaborative. Collaborative quality improvement programs including MSTCVS
are funded by Blue Cross Blue Shield of Michigan to conduct participatory, provider-driven quality improvement
initiatives, and our team has heavily leveraged these to study postoperative pain- and opioid-related outcomes
and generate best practices. The implementation and dissemination of these best practices has dramatically
reduced perioperative prescribing of opioids in the state of Michigan, and this strong partnership will enable us
to recruit thoracotomy patients from a population-based sample across diverse healthcare systems. We will
recruit 1800 patients from seven hospitals in Michigan undergoing surgery via a thoracic approach (lung
resection, esophageal resection/reconstruction, and other general thoracic surgery).
We joined the A2CPS Consortium in August 2020. Since that time, we have worked with the
consortium to harmonize our protocols and prepare for our study launch. Through the multiple workgroups, we
have determined that amendments to our protocols and procedures will be needed to harmonize with the
MCC1. Moreover, given the progress made by the consortium in the more than year of work before we joined
the consortium have made it such that we plan to launch our recruitment efforts in the second quarter of year
one instead of the third quarter.
项目摘要/摘要
慢性手术后疼痛(CPSP)是新的慢性疼痛的主要原因,发生在10%-40%的手术后
常见的外科手术。胸外科手术的慢性后遗症发生率最高。
外科疼痛(CPSP),大约30%-47%的患者在术后6个月内出现新的慢性疼痛
做手术。虽然胸部手术后CPSP的高发病率是众所周知的,但患者-和护理-
与CPSP发展有关的因素仍然不清楚。一些因素,如焦虑,已经被
然而,大多数队列缺乏评估潜在重要因素的样本量,包括
神经成像,定量感觉测试,以及基因组学、代谢组学和蛋白质组学的血液样本。
我们认为胸外科是增加急慢性疼痛的理想二次手术人群。
Signature(A2CPS)计划,补充了膝关节置换的第一个MCC群体,该群体有很多
新的CPSP发生率较低,但是确定未能解决慢性疼痛的风险因素的更好队列。我们的
密歇根大学拟建的A2CP多站点临床中心(MCC)的跨学科团队已经
无与伦比的专业知识,检查CPSP发展的表型和遗传型风险因素
在接受胸部手术的患者中。我们的PI包括一名麻醉师、两名外科医生和一名
风湿病学家在正在进行的工作中成功地合作,并在全州范围的
密歇根胸科和心血管学会开胸手术医院
外科医生(MSTCVS)质量协作。协作质量改进计划,包括MSTCVS
由密歇根州蓝十字蓝盾资助,进行参与式、供应商驱动的质量改进
我们的团队大量利用这些举措来研究术后疼痛和阿片类药物相关的结果
并生成最佳实践。这些最佳做法的实施和传播大大增加了
密歇根州减少了围手术期阿片类药物的处方,这种强有力的伙伴关系将使我们能够
从不同医疗保健系统的人群样本中招募开胸患者。我们会
从密歇根州的七家医院招募1800名通过胸部入路(肺)进行手术的患者
切除、食道切除/重建和其他普通胸部手术)。
我们于2020年8月加入A2CPS财团。从那时起,我们一直在与
财团协调我们的协议并为我们的研究发射做准备。通过多个工作组,我们
已确定需要对我们的协议和程序进行修改,以与
MCC1。此外,鉴于财团在我们加入之前一年多的工作中取得的进展,
财团已经达成协议,我们计划在今年第二季度开始招聘工作
第一季度,而不是第三季度。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Chad M Brummett其他文献
A call for community-shared decisions.
呼吁社区共同做出决定。
- DOI:
10.1136/bmjebm-2023-112641 - 发表时间:
2024 - 期刊:
- 影响因子:5.8
- 作者:
Jason N. Doctor;Daniella Meeker;Craig R Fox;Stephen D. Persell;Zachary Wagner;Kathryn Bouskill;Kyle Zanocco;Robert J Romanelli;Chad M Brummett;Allison Kirkegaard;Katherine E. Watkins - 通讯作者:
Katherine E. Watkins
Chad M Brummett的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Chad M Brummett', 18)}}的其他基金
Transition from Acute to Chronic Pain After Thoracic Surgery
胸外科手术后从急性疼痛转变为慢性疼痛
- 批准号:
10458646 - 财政年份:2020
- 资助金额:
$ 123.63万 - 项目类别:
Transition from Acute to Chronic Pain After Thoracic Surgery
胸外科手术后从急性疼痛转变为慢性疼痛
- 批准号:
10444038 - 财政年份:2020
- 资助金额:
$ 123.63万 - 项目类别:
Transition from Acute to Chronic Pain After Thoracic Surgery
胸外科手术后从急性疼痛转变为慢性疼痛
- 批准号:
10661364 - 财政年份:2020
- 资助金额:
$ 123.63万 - 项目类别:
Transition from Acute to Chronic Pain After Thoracic Surgery
胸外科手术后从急性疼痛转变为慢性疼痛
- 批准号:
10222802 - 财政年份:2020
- 资助金额:
$ 123.63万 - 项目类别:
Transition from Acute to Chronic Pain After Thoracic Surgery
胸外科手术后从急性疼痛转变为慢性疼痛
- 批准号:
10076999 - 财政年份:2020
- 资助金额:
$ 123.63万 - 项目类别:
Transition from Acute to Chronic Pain After Thoracic Surgery
胸外科手术后从急性疼痛转变为慢性疼痛
- 批准号:
10614222 - 财政年份:2020
- 资助金额:
$ 123.63万 - 项目类别:
oPIOIDS: Prevention of Iatrogenic Opioid Dependence after Surgery
阿片类药物:预防手术后医源性阿片类药物依赖
- 批准号:
9381812 - 财政年份:2017
- 资助金额:
$ 123.63万 - 项目类别:
相似海外基金
Reserch on the theory and practice of Unconstitutional Constitutional Amendment
违宪修宪理论与实践研究
- 批准号:
22K01142 - 财政年份:2022
- 资助金额:
$ 123.63万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Immobilizing vanadium with nano-oxide and biochar combined amendment and investigating the fate of amendment-vanadium complexes at varying geochemical environments of soils.
用纳米氧化物和生物炭组合改良剂固定钒,并研究改良剂-钒络合物在不同土壤地球化学环境下的命运。
- 批准号:
DDG-2022-00020 - 财政年份:2022
- 资助金额:
$ 123.63万 - 项目类别:
Discovery Development Grant
Biochar as a Soil Amendment for Revitalizing Stockpiled Soils and Facilitating Carbon Sequestration at an Oilsands Lease, Christina Lake, Alberta
生物炭作为土壤改良剂,可恢复阿尔伯塔省克里斯蒂娜湖油砂租地的储存土壤并促进碳封存
- 批准号:
561419-2020 - 财政年份:2022
- 资助金额:
$ 123.63万 - 项目类别:
Applied Research and Development Grants - Level 2
Policy framing and its legislative consequence: A comparative analysis of Copyright Act Amendment in Korea and Japan
政策框架及其立法后果:韩日著作权法修正案的比较分析
- 批准号:
22K01648 - 财政年份:2022
- 资助金额:
$ 123.63万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Efficient utilization of biochar for water remediation and soil amendment - towards a circular economy
有效利用生物炭进行水体修复和土壤改良——迈向循环经济
- 批准号:
2747765 - 财政年份:2021
- 资助金额:
$ 123.63万 - 项目类别:
Studentship
Developing a New Sustainable Product: Wood Ash Recycling as Soil Amendment
开发新的可持续产品:木灰回收作为土壤改良剂
- 批准号:
570816-2021 - 财政年份:2021
- 资助金额:
$ 123.63万 - 项目类别:
Applied Research and Development Grants - Level 1
Biochar as a Soil Amendment for Revitalizing Stockpiled Soils and Facilitating Carbon Sequestration at an Oilsands Lease, Christina Lake, Alberta
生物炭作为土壤改良剂,可恢复阿尔伯塔省克里斯蒂娜湖油砂租地的储存土壤并促进碳封存
- 批准号:
561419-2020 - 财政年份:2021
- 资助金额:
$ 123.63万 - 项目类别:
Applied Research and Development Grants - Level 2
Rock dust from mine waste as a natural media amendment in forest reclamation and the production of high value agronomic and horticultural crops
矿山废料中的岩尘作为森林开垦和高价值农业和园艺作物生产中的天然介质改良剂
- 批准号:
531858-2018 - 财政年份:2021
- 资助金额:
$ 123.63万 - 项目类别:
Collaborative Research and Development Grants
North Carolina Occupational Health Surveillance Program (Budget Amendment)
北卡罗来纳州职业健康监测计划(预算修正案)
- 批准号:
10464873 - 财政年份:2021
- 资助金额:
$ 123.63万 - 项目类别:
Efficient utilization of biochar for water remediation and soil amendment towards a circular economy
有效利用生物炭进行水修复和土壤改良,实现循环经济
- 批准号:
BB/W510361/1 - 财政年份:2021
- 资助金额:
$ 123.63万 - 项目类别:
Training Grant