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Modulators of RPS14 with broad antiviral activity

Modulators of RPS14 with broad antiviral activity
具有广泛抗病毒活性的 RPS14 调节剂
批准号：
10255320
负责人：
Noel Southall
金额：
$11.24万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10255320
关键词：
AdenovirusesAntiviral AgentsBindingBiological AssayBiologyCollaborationsDiseaseEmetineExhibitsExtramural ActivitiesGoalsInformaticsModelingPharmaceutical ChemistryPhenotypeProcessReagentResearchResearch PersonnelStructureSynthesis ChemistryTestingTranslationsUnited States National Institutes of HealthValidationWorkassay developmentbasebiophysical techniquesdesigndrug developmentdrug discoverylead optimizationnew technologynovelscreeningsmall moleculesmall molecule therapeuticstherapeutic developmenttoolvirtual screening

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英文摘要
This collaborative team aims to build on previous research by uncovering novel modulators of RPS14. Emetine, for example, binds to RPS14 exhibits broad antiviral activity. During this period, the collaborative team has identified candidate RPS14 binders using a virtual screening approach. Molecules were tested for RPS14 binding using biophysical approaches and activity was assessed in adenovirus replication assays. The team will pursue structural studies and design reagents to confirm an on-target mechanism of action.
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