Development of Malaria Transmission-Blocking Drugs

疟疾传播阻断药物的开发

• 批准号: 10253926
• 负责人: Philip Sanderson
• 金额: $ 286.43万
• 依托单位: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10253926
• 关键词: Affect; Africa South of the Sahara; Antimalarials; Biological Assay; Bite; Chills; Culicidae; Data; Development; Diarrhea; Disease; Dose; Drug Kinetics; Evaluation; FRAP1 gene; Fever; Goals; Headache; Infection prevention; Lead; Malaria; Modeling; Myalgia; Organ; Parasite Control; Parasites; Parasitic Diseases; Patients; Persons; Pharmaceutical Preparations; Pilot Projects; Plasmodium falciparum; Recovery; Research Personnel; Rodent; Scientist; Series; Sweating; Symptoms; Testing; Time; Vomiting; Work; analog; design; in vivo; lead optimization; malaria transmission; mosquito-borne; novel drug class; reduce symptoms; transmission process

Even while on current therapies, malaria patients remain infectious for a period of time, allowing further mosquito-borne transmission to others. Control of parasite transmission is critical for elimination and eradication of malaria. However, most antimalarial drugs are not active against sexual stage P. falciparum parasites called gametocytes which are responsible for the spread of malaria from person to person via mosquitoes. To begin to fill this void, investigators screened 5,215 known bioactive compounds and approved drugs for gametocytocidal activity. One compound with favorable pharmacokinetics (Torin2) was selected as the first candidate for further evaluation, including testing in an in vivo rodent malaria transmission model. Two 4 mg/kg doses completely blocked parasites ability to infect mosquitoes, and a 2 mg/kg dose gave a partial blockade, confirming the transmission-blocking activity of Torin2. Preliminary data indicate that the Torin2 target in P. falciparum is distinct from the mammalian target, allowing the design of malaria-specific derivatives. Pilot studies between the lead collaborator and NCATS scientists used a gametocyte viability assay, a cellular mTOR assay and an in vivo rodent malaria transmission model to identify new malaria-specific Torin2 analogues. This work resulted in identification of a series of compounds suitable for lead optimization. The project currently is in late-stage lead optimization, with the goal of identifying a compound with single-dose activity against all stages of the disease.

即使采用目前的治疗方法，疟疾患者仍会在一段时间内保持传染性，从而进一步通过蚊子传播给他人。控制寄生虫传播对消除和根除疟疾至关重要。然而，大多数抗疟疾药物对称为配子体的性阶段恶性疟原虫没有活性，这种寄生虫负责通过蚊子在人与人之间传播疟疾。