权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Blood flow and hemodynamics in glaucoma

青光眼的血流和血流动力学

基本信息

批准号：
10254439
负责人：
Stuart Gardiner
金额：
$ 37.82万
依托单位：
LEGACY EMANUEL HOSPITAL AND HEALTH CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-30 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10254439
关键词：
Age Angiography Area Axon Blindness Blood Pressure Monitors Blood Vessels Blood capillaries Blood flow Cell Death Cells Characteristics Chronic Clinical Clinical Management Diagnostic Diagnostic tests Disease Disease Progression Eye Eye Manifestations Fingers Functional disorder Future Glaucoma Goals Impairment Individual Lasers Measurement Measures Mechanics Metabolic Methods Nerve Degeneration Optic Disk Optical Coherence Tomography Pathogenesis Patients Physiologic Intraocular Pressure Physiologic pulse Predisposition Primary Open Angle Glaucoma Process Regimen Research Resolution Retina Retinal Ganglion Cells Risk Factors Role Shapes Stress Structure Suspect Glaucomas Testing Tissues Vasodilation Work cell injury cohort density functional loss hemodynamics human subject new technology novel diagnostics optic nerve disorder response temporal measurement theories tool

项目摘要

Project Summary / Abstract Glaucoma is a leading cause of blindness both in the US and worldwide, and is characterized by damage to and loss of retinal ganglion cells. It is known that blood flow within the optic nerve head and retina are altered in glaucomatous eyes. Flow may initially increase, but is eventually decreased in eyes with more severe glaucomatous damage. The capillary density gradually decreases as the disease progresses. There is also evidence of altered hemodynamics, in that the shape of the pulse waveform measured within the optic nerve head differs between glaucomatous and healthy eyes. However, it is not yet known whether these changes occur because axon loss has reduced the metabolic demand; or whether the changes contribute towards retinal ganglion cell damage and death; or both. This proposal will examine in detail the changes in blood flow and hemodynamics that occur at different stages of glaucoma. We will leverage new technologies to measure different aspect of the vasculature, and relate them to disease status and progression, both individually and in combination. In Aim 1, we will measure blood flow within the optic nerve head and as it passes through the peripapillary retina, both to quantify the amount of flow and to measure and quantify the pulse waveform. This will allow us to test whether the observed differences in flow in eyes that are considered glaucoma suspects are an early part of the disease process that could be measured diagnostically, and/or reflect longstanding differences that could be used to predict susceptibility to glaucoma. In Aim 2, we will also measure the systemic pulse waveform in the same individuals. This will allow us to determine whether differences in hemodynamics that could be measured diagnostically are localized to the eye due to pathophysiologic processes; and/or represent a systemic risk factor for glaucoma. In Aim 3, we will measure the area of perfused blood vessels, both in the optic nerve head and the peripapillary retina. This will allow us to determine whether flow is altered within the remaining vessels after some of the capillaries have been pruned, potentially causing further damage. Together, these aims will reveal multiple facets of the relation between vascular changes and glaucoma, and answer major questions that have remained unresolved. Overall, the project will provide substantial advances in both diagnostic tools and mechanistic understanding of glaucoma.

项目摘要/摘要