A Compact, 395 GHz Traveling Wave Tube (TWT) Amplifier for DNP-NMR and EPR Spectroscopy

项目摘要/摘要 我们计划开发一种紧凑型、高性价比的行波管(TWT)放大器，工作频率为395 GHz，功率为1.5W 用于动态核极化的连续波功率和20 GHz瞬时带宽 (DNP)增强固体和溶液核磁共振和电子顺磁共振(EPR) 光谱学。使用DNP，核磁共振实验中固有的小信号强度可以增强高达 两个数量级。这一显著提高的总体灵敏度将对分析 核磁共振波谱及其在生物大分子结构测定中的应用 方法：研究方法。 目前，使用低功率固态电源(其输出功率被限制为几个)来执行DNP MW(频率&GT；300 GHz)和20-30K范围内的低温(以补偿低 微波功率)或可产生50W功率的大型回旋管系统。回旋管是 价格昂贵，没有足够的调谐带宽(&lt；0.1%)来研究广泛的 DNP实验因此需要在核磁共振磁体中使用昂贵的扫描线圈。拟建的荃湾区将会 解决所有上述问题。行波管的成本预计不到回旋管的四分之一。 系统，提供20 GHz的瞬时带宽，将是一个紧凑的桌面系统。这些 优势将允许更多的研究人员利用DNP提供的灵敏度提升 在核磁共振实验中。 在第一阶段，我们将设计、构建和测试一个原型系统。这样一个系统的成功演示 在第一阶段，我们将能够在第二阶段开发出性能优越的商业产品。这个 该技术是可扩展的，可以在高达527 GHz(800 MHz核磁共振)的频率下使用。更高的山峰 该设备的电源版本将推动高场EPR光谱学的最先进水平。作为终极 该项目的结果是，我们预计Bridge12将为DNP提供395 GHz(600 MHz核磁共振)的商业行波管- 核磁共振和电子顺磁共振波谱。这将大大加快生物大分子的结构测定。 与NIH资助的人类疾病研究的相关性。

Project Summary / Abstract We propose to develop a compact, cost-effective Traveling Wave Tube (TWT) amplifier at 395 GHz with 1.5 W continuous wave power and 20 GHz instantaneous bandwidth for application in Dynamic Nuclear Polarization (DNP) enhanced solid-state and solution-state NMR and Electron Paramagnetic Resonance (EPR) spectroscopy. With DNP, the inherently small signal intensities in a NMR experiment can be enhanced by up to two orders of magnitude. This significantly increased overall sensitivity will be highly beneficial for analytical applications of NMR spectroscopy as well as in the structure determination of bio-macromolecules using NMR methods. Currently, DNP is performed with either low power solid-state sources (whose output power is limited to a few mW at frequencies > 300 GHz) and at low temperatures in the range of 20-30 K (to compensate for low microwave power) or with large, gyrotron systems which can generate 50 W of power. Gyrotrons are expensive and do not possess sufficient tuning bandwidth (<0.1%) necessary for investigating a wide range of DNP experiments and thus require expensive sweep coils in the NMR magnets. The proposed TWT will address all the above concerns. The TWT is expected to cost less than one-fourth of the cost of a gyrotron system, provide 20 GHz of instantaneous bandwidth and will be a compact table-top system. These advantages will allow a larger number of researchers to take advantage of the sensitivity boost offered by DNP in NMR experiments. In Phase I, we will design, build and test a prototype system. The successful demonstration of such a system in Phase I will enable us to develop a commercial product in Phase II with superior performance. The technology is scalable and can be used at frequencies as high as 527 GHz (800 MHz NMR). A higher peak power version of the device will advance the state-of-the-art in high field EPR spectroscopy. As an ultimate result of this project, we expect Bridge12 to offer a commercial TWT at 395 GHz (600 MHz NMR) for DNP- NMR and EPR spectroscopy. This will greatly accelerate structure determination of bio-macromolecules of relevance to human disease research funded by NIH.