Organ Specific Project

器官特定项目

基本信息

项目摘要

PROJECT ABSTRACT The overarching goal of the Human BioMolecular Atlas Program (HuBMAP) and specifically of Tissue Mapping Centers is to generate high resolution 3D biomolecular maps for non-diseased human organs. The overall objective of this pancreas organ specific project (OSP) is to identify and collect whole disease-free pancreas from donors across different sexes and ethnicities, to develop a robust system for tissue processing and distribution, and to generate multi-scale, high resolution, 3D multi-omics molecular atlases of functional regions of human pancreas. This OSP integrates unique expertise ranging from pancreas biology, diabetes, organ procurement, tissue processing, deep-tissue fluorescence imaging analysis (University of Florida), advanced multi-omics mass spectrometry-based tissue mapping (PNNL), and sophisticated high-throughput bioinformatics and 3D reconstruction of molecular maps (Texas Advanced Computing Center) of regions of pancreas, such as islets. Specifically, we will: (1) Identify and collect whole disease-free pancreas from donors through collaboration with the Organ Procurement Organizations (OPO) and Research Intermediaries (RI), and develop infrastructure for timely referral and donor collection, as well as a robust, web-based, specimen inventory and request system that accesses a catalogue of representative sample derivative meta-data (i.e. whole slide image or cytometry) of quality and composition; (2) Provide preserved, embedded, and sectioned pancreas tissue using pancreatic processing processes that have carefully mapped the pancreas in 2D; (3) Perform multi-scale and multi-omic imaging or spatially resolved characterization of pancreas and function-guided tissue sections through the characterization pipeline; and (4) Create comprehensive 3-D biomolecular atlas of pancreas that maps protein, metabolite, and lipid expression throughout functional regions of the pancreas through the Data Analysis Core.
项目摘要

项目成果

期刊论文数量(0)
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CLAYTON E MATHEWS其他文献

CLAYTON E MATHEWS的其他文献

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{{ truncateString('CLAYTON E MATHEWS', 18)}}的其他基金

Discovery and Roles of In Situ Islet Neoantigens in Human Type 1 Diabetes
原位胰岛新抗原在人类 1 型糖尿病中的发现及其作用
  • 批准号:
    10589578
  • 财政年份:
    2023
  • 资助金额:
    $ 70.21万
  • 项目类别:
Determining the mechanism of IFIH1 disease-associated variants on beta-cell and immune responses in Type 1 diabetes
确定 1 型糖尿病中 IFIH1 疾病相关变异对 β 细胞和免疫反应的机制
  • 批准号:
    10903049
  • 财政年份:
    2023
  • 资助金额:
    $ 70.21万
  • 项目类别:
Determining the mechanism of IFIH1 disease-associated variants on beta-cell and immune responses in Type 1 diabetes
确定 1 型糖尿病中 IFIH1 疾病相关变异对 β 细胞和免疫反应的机制
  • 批准号:
    10417267
  • 财政年份:
    2020
  • 资助金额:
    $ 70.21万
  • 项目类别:
Organ Specific Project
器官特定项目
  • 批准号:
    10685591
  • 财政年份:
    2020
  • 资助金额:
    $ 70.21万
  • 项目类别:
Organ Specific Project
器官特定项目
  • 批准号:
    10118877
  • 财政年份:
    2020
  • 资助金额:
    $ 70.21万
  • 项目类别:
Multi-omic 3D tissue maps for a Human BioMolecular Atlas
人类生物分子图谱的多组学 3D 组织图谱
  • 批准号:
    10649957
  • 财政年份:
    2020
  • 资助金额:
    $ 70.21万
  • 项目类别:
Determining the mechanism of IFIH1 disease-associated variants on beta-cell and immune responses in Type 1 diabetes
确定 1 型糖尿病中 IFIH1 疾病相关变异对 β 细胞和免疫反应的机制
  • 批准号:
    10263321
  • 财政年份:
    2020
  • 资助金额:
    $ 70.21万
  • 项目类别:
Genetic Regulation of Human Beta Cell Destruction
人类β细胞破坏的基因调控
  • 批准号:
    8813679
  • 财政年份:
    2014
  • 资助金额:
    $ 70.21万
  • 项目类别:
mt-Nd2 and Resistance to Autoimmune Diabetes
mt-Nd2 与自身免疫性糖尿病的抵抗力
  • 批准号:
    7998873
  • 财政年份:
    2010
  • 资助金额:
    $ 70.21万
  • 项目类别:
mt-Nd2 and Resistance to Autoimmune Diabetes
mt-Nd2 与自身免疫性糖尿病的抵抗力
  • 批准号:
    8297271
  • 财政年份:
    2006
  • 资助金额:
    $ 70.21万
  • 项目类别:

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    2021
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Building a Multidisciplinary Research Program to Address Hypertension Disparities:Exploring the Neurocognitive Mechanisms of a Self-Management Intervention for African American Women with Hypertension
建立一个多学科研究计划来解决高血压差异:探索非裔美国高血压女性自我管理干预的神经认知机制
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