Organ Specific Project
器官特定项目
基本信息
- 批准号:10259784
- 负责人:
- 金额:$ 70.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-10 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAddressAfrican AmericanAgeAge-YearsAmylasesAnatomyAntibodiesAntigen-Presenting CellsArteriesAtlasesBioinformaticsBiologyBiomedical ResearchCatalogsCaucasiansCell NucleusCellsCollaborationsCollagenCollectionCytometryDataData AnalysesDiabetes MellitusDiseaseDrug or chemical Tissue DistributionDuct (organ) structureEnsureEquipment and supply inventoriesEthnic OriginFemaleFibrosisFloridaFutureGeneticGoalsGuidelinesHead of pancreasHispanicsHumanHuman BioMolecular Atlas ProgramImageIncidenceInformation DistributionInfrastructureInsulin-Dependent Diabetes MellitusKnowledgeLinkLipidsLocationLymphocyteMalignant neoplasm of pancreasMapsMass Spectrum AnalysisMeasurementMetabolismMetadataMolecularMolecular ProfilingNCAM1 geneNerveNon-Insulin-Dependent Diabetes MellitusOnline SystemsOrganOrgan ProcurementsOutcomePECAM1 genePTPRC genePancreasPancreatic DiseasesPancreatitisPeroxidasesPhysiologyProcessProductionProteinsRNARaceRegulationResearchResolutionSamplingSex BiasSlideSmooth Muscle Actin Staining MethodSpecimenStainsStructureSynaptophysinSystemTailTechnologyTexasThickTimeTissuesTransplantationUnited States National Institutes of HealthUniversitiesVascularizationWorkbasefluorescence imaginginsightisletmalemultiple omicsnerve supplyneutrophilpreservationprognosticprotein metabolitereconstructionsextissue processingtumortumorigenesiswhole slide imaging
项目摘要
PROJECT ABSTRACT
The overarching goal of the Human BioMolecular Atlas Program (HuBMAP) and specifically of Tissue Mapping
Centers is to generate high resolution 3D biomolecular maps for non-diseased human organs. The overall
objective of this pancreas organ specific project (OSP) is to identify and collect whole disease-free pancreas
from donors across different sexes and ethnicities, to develop a robust system for tissue processing and
distribution, and to generate multi-scale, high resolution, 3D multi-omics molecular atlases of functional
regions of human pancreas.
This OSP integrates unique expertise ranging from pancreas biology, diabetes, organ procurement, tissue
processing, deep-tissue fluorescence imaging analysis (University of Florida), advanced multi-omics mass
spectrometry-based tissue mapping (PNNL), and sophisticated high-throughput bioinformatics and 3D
reconstruction of molecular maps (Texas Advanced Computing Center) of regions of pancreas, such as islets.
Specifically, we will: (1) Identify and collect whole disease-free pancreas from donors through collaboration
with the Organ Procurement Organizations (OPO) and Research Intermediaries (RI), and develop
infrastructure for timely referral and donor collection, as well as a robust, web-based, specimen inventory and
request system that accesses a catalogue of representative sample derivative meta-data (i.e. whole slide image
or cytometry) of quality and composition; (2) Provide preserved, embedded, and sectioned pancreas tissue
using pancreatic processing processes that have carefully mapped the pancreas in 2D; (3) Perform multi-scale
and multi-omic imaging or spatially resolved characterization of pancreas and function-guided tissue sections
through the characterization pipeline; and (4) Create comprehensive 3-D biomolecular atlas of pancreas that
maps protein, metabolite, and lipid expression throughout functional regions of the pancreas through the Data
Analysis Core.
项目摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CLAYTON E MATHEWS其他文献
CLAYTON E MATHEWS的其他文献
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{{ truncateString('CLAYTON E MATHEWS', 18)}}的其他基金
Discovery and Roles of In Situ Islet Neoantigens in Human Type 1 Diabetes
原位胰岛新抗原在人类 1 型糖尿病中的发现及其作用
- 批准号:
10589578 - 财政年份:2023
- 资助金额:
$ 70.21万 - 项目类别:
Determining the mechanism of IFIH1 disease-associated variants on beta-cell and immune responses in Type 1 diabetes
确定 1 型糖尿病中 IFIH1 疾病相关变异对 β 细胞和免疫反应的机制
- 批准号:
10903049 - 财政年份:2023
- 资助金额:
$ 70.21万 - 项目类别:
Determining the mechanism of IFIH1 disease-associated variants on beta-cell and immune responses in Type 1 diabetes
确定 1 型糖尿病中 IFIH1 疾病相关变异对 β 细胞和免疫反应的机制
- 批准号:
10417267 - 财政年份:2020
- 资助金额:
$ 70.21万 - 项目类别:
Multi-omic 3D tissue maps for a Human BioMolecular Atlas
人类生物分子图谱的多组学 3D 组织图谱
- 批准号:
10649957 - 财政年份:2020
- 资助金额:
$ 70.21万 - 项目类别:
Determining the mechanism of IFIH1 disease-associated variants on beta-cell and immune responses in Type 1 diabetes
确定 1 型糖尿病中 IFIH1 疾病相关变异对 β 细胞和免疫反应的机制
- 批准号:
10263321 - 财政年份:2020
- 资助金额:
$ 70.21万 - 项目类别:
Genetic Regulation of Human Beta Cell Destruction
人类β细胞破坏的基因调控
- 批准号:
8813679 - 财政年份:2014
- 资助金额:
$ 70.21万 - 项目类别:
mt-Nd2 and Resistance to Autoimmune Diabetes
mt-Nd2 与自身免疫性糖尿病的抵抗力
- 批准号:
7998873 - 财政年份:2010
- 资助金额:
$ 70.21万 - 项目类别:
mt-Nd2 and Resistance to Autoimmune Diabetes
mt-Nd2 与自身免疫性糖尿病的抵抗力
- 批准号:
8297271 - 财政年份:2006
- 资助金额:
$ 70.21万 - 项目类别:
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