Clinical Laboratory Core

临床实验室核心

• 批准号: 10259691
• 负责人: JENNIFER W. TIDEY
• 金额: $ 65.72万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10259691
• 关键词: Achievement; Adverse event; Alcohols; Aliquot; Behavioral; Biological; Biological Assay; Biological Markers; Biological databases; Blood; Cannabis; Carcinogen exposure; Centers of Research Excellence; Chronic; Chronic Disease; Clinical; Complement; Consult; Data; Data Analyses; Data Collection; Databases; Development; Disease; Eligibility Determination; Ensure; Environmental Risk Factor; Enzymes; Equipment; Faculty; Funding; Future; Goals; HIV; Hormones; Hospitals; Human; Human Resources; Hypertension; Immune system; Inflammatory; Intervention; Laboratories; Link; Liver; Lung; Measures; Medical; Medical History; Methodology; NCI Center for Cancer Research; Opioid; Outcome; Patients; Physical Examination; Physiological; Pilot Projects; Placebos; Procedures; Process; Questionnaires; Randomized; Research; Research Design; Research Personnel; Research Project Grants; Research Support; Resources; Rheumatoid Arthritis; Rhode Island; Risk; Risk Factors; Saliva; Sampling; Scientist; Services; Stress; Substance Use Disorder; Techniques; Testing; Tobacco; Training; Universities; Urine; addiction; behavioral pharmacology; biobank; biobehavior; causal model; chronic pain; cost; data management; design; disorder risk; experience; experimental study; follow-up; improved; innovation; insight; multidisciplinary; opioid use disorder; participant safety; patient population; pulmonary function; research and development; response; secondary analysis; substance use; systemic inflammatory response; web portal

Abstract Substance use is associated with increased risk of, progression to, and negative outcomes from chronic disease. Although associations between substance use disorders (SUDs) and chronic disease are well documented, specific mechanisms underlying these associations are poorly understood and underappreciated. Experimental studies that use placebo-controlled, randomized designs are essential for understanding physiological mechanisms that link SUDs and chronic disease. The research and pilot projects in the Center for Addiction and Disease Risk Exacerbation (CADRE) COBRE at Brown University will investigate physiological mechanisms underlying the effects of opioids, cannabis, tobacco, and alcohol on risks for and progression of SUD-related disease. Mechanisms to be studied in the initial four CADRE research projects include systemic inflammation, immune system dysregulation, high blood pressure, pulmonary effects and carcinogen exposure. The CADRE's Clinical Laboratory Core (CLC) will provide the current and future CADRE research and pilot project investigators with the space, supplies, equipment, technical capability, scientific expertise and data management/analysis expertise necessary to meet the needs of their projects. These resources are not otherwise available at Brown, and are essential for achieving the Specific Aims of the CADRE projects. Provision of these resources via the CLC will improve efficiency, consistency and economy of scale across projects. Specific Aim 1 of the CLC Core is to provide resources necessary for developing and sustaining a multi-disciplinary center focused on SUDs and chronic disease. Specific Aim 2 is to facilitate and coordinate assay and other services provided to the CADRE investigators through neighboring COBREs. Specific Aim 3, an exploratory aim, is to build a center-wide biobank and database of biological, behavioral and environmental risk factors associated with the development and progression of SUDs and chronic disease. Resources provided by the CLC will build on and complement, but not overlap, resources currently available at Brown. The successful achievement of these aims will be a thematically- and technically-linked center that supports the initial and future projects, enhances the competitiveness of the project leaders for independent external funding, becomes a national leader in understanding biobehavioral mechanisms linking SUDs and chronic disease, and serves as a resource for training and research within Brown, regionally, and nationally.

抽象的 物质使用与慢性病的风险增加、进展和负面结果有关 疾病。尽管物质使用障碍 (SUD) 与慢性病之间存在良好的关联 据记载，这些关联背后的具体机制人们知之甚少，也没有得到充分重视。 使用安慰剂对照、随机设计的实验研究对于理解这一点至关重要 将 SUD 与慢性疾病联系起来的生理机制。中心的研究和试点项目 布朗大学的成瘾和疾病风险加剧 (CADRE) COBRE 将进行调查 阿片类药物、大麻、烟草和酒精对风险的影响的生理机制 SUD 相关疾病的进展。最初四个 CADRE 研究项目要研究的机制 包括全身炎症、免疫系统失调、高血压、肺部影响和 致癌物质暴露。 CADRE 的临床实验室核心 (CLC) 将提供当前和未来的 CADRE 研究和试点项目研究人员具有空间、物资、设备、技术能力、科学能力 满足项目需求所需的专业知识和数据管理/分析专业知识。这些 布朗大学无法提供这些资源，但这些资源对于实现布朗大学的具体目标至关重要 干部项目。通过 CLC 提供这些资源将提高效率、一致性和经济性 跨项目规模。 CLC 核心的具体目标 1 是为开发和 维持一个专注于 SUD 和慢性病的多学科中心。具体目标 2 是促进和 通过邻近的 COBRE 协调向 CADRE 调查人员提供的检测和其他服务。 具体目标 3 是一个探索性目标，是建立一个中心范围内的生物库和生物、行为和数据库。 与 SUD 和慢性疾病的发生和进展相关的环境风险因素。 CLC 提供的资源将建立在现有资源的基础上并对其进行补充，但不会重叠。 棕色的。成功实现这些目标将是一个主题和技术相关的中心， 支持初始和未来的项目，增强项目负责人独立的竞争力 外部资助，成为理解连接 SUD 和生物行为机制的国家领导者 慢性病，并作为布朗大学内部、区域和国家培训和研究的资源。