Non-HFE haemochromatosis in Australia: natural history and molecular characterisation

遗传性血色病（HH）是一种以过度铁吸收和铁在身体器官（如肝脏）中积聚为特征的疾病。过量的铁可能是有毒的，并导致疾病。大多数HH由HFE基因突变引起。其他形式是由其他基因突变引起的。该项目将发现一种新形式的HH，它与任何先前已知的基因无关。该项目旨在通过对一个大家庭进行遗传分析，找到这种新疾病的基因。

Hereditary haemochromatosis (HH) is a disorder characterised by excessive iron absorption and build up of iron in body organs such as the liver. The excess iron can be toxic and cause disease. Most HH is caused by mutations in the HFE gene. Other forms are caused by mutations in other genes. This project will characterise a new form of HH that is unrelated to any of the previously known genes. The project aims to find the gene for this new condition by genetic analysis in a large family.