Deciphering Signalling Pathways Regulating Iron Homeostasis

破译调节铁稳态的信号通路

• 批准号: nhmrc : 1031325
• 负责人: Dr Daniel Wallace
• 金额: $ 27.17万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/deciphering-signalling-pathways-iron-homeostasis/110799
• 关键词: Deciphering; Signalling; Pathways; Regulating; Iron

Iron overload and anaemia are two of the most significant health problems affecting humans. Understanding how the body regulates iron levels is key to our understanding of these disorders and to the future development of new therapies. This research is aimed at understanding how a hormone produced in the liver called hepcidin that maintains iron balance is regulated. This research may lead to novel therapies aimed at correcting the iron balance in conditions of iron overload or anaemia.

铁超载和贫血是影响人类的两个最严重的健康问题。了解身体如何调节铁水平是我们理解这些疾病和未来开发新疗法的关键。这项研究旨在了解肝脏中产生的一种名为海普西丁的荷尔蒙是如何调节的，这种荷尔蒙维持铁平衡。这项研究可能会带来新的疗法，旨在纠正铁超载或贫血条件下的铁平衡。