Novel genetic and environmental modifiers of the risk of iron overload-related disease in HFE-associated hereditary haemochromatosis in cohort of middle-aged Australians

澳大利亚中年人群中 HFE 相关遗传性血色病患者铁超载相关疾病风险的新遗传和环境调节剂

• 批准号: nhmrc : 1032598
• 负责人: A/Pr Lyle Gurrin
• 金额: $ 30.12万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-genetic-environmental-aged-australians/110859
• 关键词: Novel; genetic; environmental; modifiers; risk

People who carry mutations in the HFE gene are pre-disposed to body iron overload but not all of them developed subsequent disease. According to the investigators of the “HealthIron” study in Melbourne, only 28% of men and 1% of women with faulty HFE genes go on to develop disease. This study has recruited more than 1,000 people from the community, and will determine which environmental and genetic risk factors stop people with iron overload from getting symptoms of disease.

携带HFE基因突变的人易患体内铁超载，但并非所有人都发生了后续疾病。根据墨尔本“健康铁”研究的调查人员，只有28%的男性和1%的女性有缺陷的HFE基因继续发展疾病。这项研究从社区招募了1,000多人，并将确定哪些环境和遗传风险因素阻止铁超载患者出现疾病症状。