Flu Dynamics COVID-19 Supplement

项目总结/摘要 SARS-COV-2是导致冠状病毒病（COVID）的病毒，于2019年底在中国出现。它迅速 在全世界蔓延，目前正在造成发病率和死亡率很高的大流行病。因为SARS-COV-2是 人类中的一种新型病毒，我们对这种病毒的理解存在许多基本知识空白， 疾病为了对尼加拉瓜的SARS-COV-2进行详细调查，我们建议增加 SARS-COV-2旨在我们现有的家庭流感队列研究。研究问题解决 在现有基础设施的基础上进行住户群组研究。我们特别 补充说，将在我们正在进行的队列研究中收集的样本中添加SARS-COV-2检测 收集SARS-COV-2感染者周围的血液样本，并进行家庭SARS- COV-2传播研究。该提案解决了COVID自然史知识的主要空白 和传输。因此，及时和充分准备进行大量的公共卫生和科学研究， 冲击

PROJECT SUMMARY/ABSTRACT SARS-COV-2, the virus that causes Coronavirus Disease (COVID) emerged in China in late 2019. It rapidly spread worldwide and is now causing a pandemic with high morbidity and mortality. Because SARS-COV-2 is a novel virus in humans, there are many fundamental knowledge gaps in our understanding of the virus and disease. To undertake a detailed investigation of SARS-COV-2 in Nicaragua, we propose to add on SARS-COV-2 aims to our existing Household Influenza Cohort Study. The research questions addressed build naturally on the infrastructure currently in place to conduct the Household Cohort Study. Specifically, we will add SARS-COV-2 testing on to samples that are already collected through our ongoing cohort study, add the collection of blood samples around SARS-COV-2 infection in participants, and perform a household SARS- COV-2 transmission study. This proposal addresses major gaps in knowledge on COVID natural history and transmission. It is thus timely and well-poised to have substantial public health and scientific impact.