Flu Dynamics COVID-19 Supplement

流感动力学 COVID-19 补充资料

• 批准号: 10265650
• 负责人: AUBREE L GORDON
• 金额: $ 30.81万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-28 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10265650
• 关键词: 2019-nCoV; Address; Affect; Blood specimen; COVID-19; COVID-19 testing; China; Climate; Cohort Studies; Collection; Data; Developing Countries; Household; Human; Influenza; Infrastructure; Integration Host Factors; Investigation; Knowledge; Morbidity - disease rate; Nicaragua; Participant; Public Health; Research; SARS-CoV-2 infection; SARS-CoV-2 transmission; Sampling; Time; Viral; Virus; Virus Diseases; coronavirus disease; disease natural history; disorder control; flu; flu transmission; improved; influenzavirus; mortality; novel virus; pandemic disease; transmission process; viral transmission

PROJECT SUMMARY/ABSTRACT SARS-COV-2, the virus that causes Coronavirus Disease (COVID) emerged in China in late 2019. It rapidly spread worldwide and is now causing a pandemic with high morbidity and mortality. Because SARS-COV-2 is a novel virus in humans, there are many fundamental knowledge gaps in our understanding of the virus and disease. To undertake a detailed investigation of SARS-COV-2 in Nicaragua, we propose to add on SARS-COV-2 aims to our existing Household Influenza Cohort Study. The research questions addressed build naturally on the infrastructure currently in place to conduct the Household Cohort Study. Specifically, we will add SARS-COV-2 testing on to samples that are already collected through our ongoing cohort study, add the collection of blood samples around SARS-COV-2 infection in participants, and perform a household SARS- COV-2 transmission study. This proposal addresses major gaps in knowledge on COVID natural history and transmission. It is thus timely and well-poised to have substantial public health and scientific impact.

项目摘要/摘要 2019年末，导致冠状病毒病的SARS-COV-2病毒在中国出现。它迅速地 在世界范围内传播，现在正在造成高发病率和高死亡率的大流行。因为SARS-COV-2是 作为一种新的人类病毒，我们对该病毒的了解存在许多基本的知识空白 疾病。为了对尼加拉瓜的SARS-COV-2进行详细的调查，我们建议增加 SARS-COV-2旨在对我们现有的家庭流感队列进行研究。所涉及的研究问题 自然地建立在现有基础设施的基础上，进行家庭队列研究。具体来说，我们 将在我们正在进行的队列研究中收集的样本上添加SARS-COV-2检测，添加 采集参与者感染SARS-COV-2周围的血液样本，并进行家庭SARS- 冠状病毒2型传播研究。这项建议解决了有关冠状病毒自然病史知识的主要空白 和变速箱。因此，它是及时和有利的，有大量的公共卫生和科学 冲击力。

项目成果

Clinical Spectrum of Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Protection From Symptomatic Reinfection.

• DOI: 10.1093/cid/ciab717
• 发表时间: 2022-08-24
• 期刊: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
• 作者: Maier HE;Kuan G;Saborio S;Carrillo FAB;Plazaola M;Barilla C;Sanchez N;Lopez R;Smith M;Kubale J;Ojeda S;Zuniga-Moya JC;Carlson B;Lopez B;Gajewski AM;Chowdhury M;Harris E;Balmaseda A;Gordon A
• 通讯作者: Gordon A

Antibody responses to influenza A(H1N1)pdm infection.

• DOI: 10.1016/j.vaccine.2020.04.069
• 发表时间: 2020-06-02
• 期刊: Vaccine
• 影响因子: 5.5
• 作者: Wraith S;Nachbagauer R;Balmaseda A;Stadlbauer D;Ojeda S;Rajabhathor A;Lopez R;Guglia AF;Sanchez N;Amanat F;Gresh L;Kuan G;Krammer F;Gordon A
• 通讯作者: Gordon A

Obesity Increases the Duration of Influenza A Virus Shedding in Adults.

• DOI: 10.1093/infdis/jiy370
• 发表时间: 2018-09-22
• 期刊: The Journal of infectious diseases
• 作者: Maier HE;Lopez R;Sanchez N;Ng S;Gresh L;Ojeda S;Burger-Calderon R;Kuan G;Harris E;Balmaseda A;Gordon A
• 通讯作者: Gordon A

The Spectrum of Influenza in Children.

• DOI: 10.1093/cid/ciac734
• 发表时间: 2023-02-08
• 期刊: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Infection-Induced Immunity Is Associated With Protection Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Decreased Infectivity.

• DOI: 10.1093/cid/ciad074
• 发表时间: 2023-06-16
• 期刊: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America