Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS)

主要研究者：Anabel，Kathryn/Sharma Anjali 项目总结/摘要 随着越来越有效的普遍抗逆转录病毒疗法（ART），艾滋病毒感染者（PLWH）现在可以 都过着正常的生活然而，随着这一成功，出现了一系列与艾滋病毒相关的慢性合并症， 其机制知之甚少，但被认为与炎症和免疫激活有关。 随着PLWH年龄的增长，他们在比预期年龄更小的时候就经历了非艾滋病合并症的高负担， 包括心血管和代谢疾病、癌症、神经认知和功能障碍- 导致一些人认为艾滋病毒可能会加重和加速衰老。妇女机构间艾滋病毒 研究（WIHS）和多中心艾滋病队列研究（MACS）队列，长期随访超过25岁， 35年提供了衡量艾滋病毒相关共病的发病、进展和影响的能力， 为心血管疾病发病机制的重要转化研究提供平台 (CVD)、人乳头瘤病毒（HPV）、衰老和HIV疾病进展。这两个非常成功的， 对于非常重要的队列合并，布朗克斯临床研究中心（CRS）将支持新的合并 队列研究（CCS）旨在了解和推进艾滋病毒感染及其治疗的研究， 重点关注与艾滋病毒相关的合并症和艾滋病毒感染的老龄化。布朗克斯CRS将提供科学的领导， CCS在三个特定领域：CVD，微生物组研究，HPV感染和疾病。特别是 布朗克斯CRS将提供创新的科学领导，在PLWH中研究CVD， 超声心动图研究和高素质的回声阅读中心，包括尖端的心血管 影像学，以及CVD与炎症标志物，代谢组学和微生物组学的研究， PLWH。布朗克斯CRS将继续跟踪我们大量的性格特征良好的人， 没有艾滋病毒，以及招募主要是种族和少数民族的男子和妇女与艾滋病毒或艾滋病毒的风险， 反映我们当地的纽约市艾滋病毒流行，从而使我们能够调查年龄，性别，种族/民族的影响， 艾滋病毒疾病进展的健康差异及其与整个生命周期共病的关系。的 这些研究的价值远远超出了美国，为全球艾滋病毒流行和艾滋病感染者的护理提供信息。

Principal Investigator: Anastos, Kathryn/Sharma Anjali PROJECT SUMMARY/ABSTRACT With increasingly effective universal antiretroviral therapy (ART), people living with HIV (PLWH) may now live nearly normal lifespans. With that success however, comes a series of chronic HIV-related comorbidities, whose mechanisms are poorly understood, but thought to be related to inflammation and immune activation. As PLWH age, they are experiencing this high burden of non-AIDS comorbidities at younger than expected age, including cardiovascular and metabolic diseases, cancers, and neurocognitive and functional impairment - leading some to suggest that HIV may both accentuate AND accelerate aging. The Women's Interagency HIV Study (WIHS) and the Multicenter AIDS Cohort Study (MACS) cohorts, with long-term follow up over 25 and 35 years provide the ability to measure the onset, progression and impact of HIV-related comorbid disease and provide a platform for critically important translational studies of pathogenesis in cardiovascular disease (CVD), human papillomavirus (HPV), aging, and HIV-disease progression. As these two highly successful and critically important cohorts merge, the Bronx Clinical Research Site (CRS) will support the new Combined Cohort Study (CCS) in an effort to understand and advance the study of HIV infection and its treatment, with a focus on HIV-related comorbidities and aging with HIV. The Bronx CRS will provide scientific leadership to the CCS in three specific areas: CVD, microbiome studies, and HPV infection and disease. In particular, the Bronx CRS will provide innovative scientific leadership in studying CVD among PLWH with a longitudinal echocardiography study and a high-caliber Echo Reading Center, including cutting-edge cardiovascular imaging, and the study of CVD in relation to inflammatory markers, metabolomics, and microbiome among PLWH. The Bronx CRS will continue to follow our large numbers of well-characterized persons living with and without HIV, as well as recruit primarily racial and ethnic minority men and women with or at-risk for HIV to reflect our local NYC HIV epidemic, thus allowing us to investigate the impact of age, sex, race/ethnicity, and health disparities on HIV disease progression and its relation to comorbid illnesses across the lifespan. The value of these studies goes far beyond the United States, to inform the global HIV epidemic, and care of PLWH.