Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS)

主要调查者：Anastos，Kathryn/Sharma Anjali 项目摘要/摘要 随着普遍抗逆转录病毒疗法(ART)的日益有效，艾滋病毒携带者(PLWH)现在可能 过着近乎正常的生活。然而，随着这种成功，一系列与艾滋病毒相关的慢性并发症也随之而来， 其机制目前知之甚少，但被认为与炎症和免疫激活有关。 随着PLWH年龄的增长，他们正经历着比预期年龄更小的非艾滋病并存的沉重负担， 包括心血管和新陈代谢疾病、癌症以及神经认知和功能障碍- 这导致一些人认为艾滋病毒可能既会加剧衰老，又会加速衰老。女性机构间艾滋病毒 研究(WIHS)和多中心艾滋病队列研究(MACS)队列，长期随访超过25和 35年提供了衡量艾滋病毒相关并存疾病的发病、进展和影响的能力 为心血管疾病发病机制的极其重要的翻译研究提供平台 心血管疾病(CVD)、人乳头瘤病毒(HPV)、衰老和艾滋病毒疾病进展。因为这两个非常成功的人 至关重要的队列合并，布朗克斯临床研究网站(CRS)将支持新的合并 队列研究(CCS)，以努力了解和推进艾滋病毒感染及其治疗的研究， 重点关注艾滋病毒相关的合并症和艾滋病毒的老龄化。布朗克斯CRS将提供科学领导，以 三个特定领域的CCS：心血管疾病、微生物组研究以及HPV感染和疾病。尤其是， 布朗克斯CRS将在研究PLWH中的心血管疾病方面提供创新的科学领导，纵向 超声心动图研究和高质量的回声阅读中心，包括尖端心血管 影像，以及心血管疾病与炎症标记物、代谢组学和微生物组之间的关系的研究 PLWH。布朗克斯CRS将继续跟踪我们大量特征良好的与 没有艾滋病毒，以及主要招募感染艾滋病毒或有艾滋病毒风险的少数族裔男子和妇女 反映我们纽约市当地的艾滋病毒流行情况，从而使我们能够调查年龄、性别、种族/民族和 艾滋病毒疾病进展方面的健康差异及其与一生中合并疾病的关系。这个 这些研究的价值远远超出了美国，为全球艾滋病毒流行和PLWH的护理提供了信息。

Principal Investigator: Anastos, Kathryn/Sharma Anjali PROJECT SUMMARY/ABSTRACT With increasingly effective universal antiretroviral therapy (ART), people living with HIV (PLWH) may now live nearly normal lifespans. With that success however, comes a series of chronic HIV-related comorbidities, whose mechanisms are poorly understood, but thought to be related to inflammation and immune activation. As PLWH age, they are experiencing this high burden of non-AIDS comorbidities at younger than expected age, including cardiovascular and metabolic diseases, cancers, and neurocognitive and functional impairment - leading some to suggest that HIV may both accentuate AND accelerate aging. The Women's Interagency HIV Study (WIHS) and the Multicenter AIDS Cohort Study (MACS) cohorts, with long-term follow up over 25 and 35 years provide the ability to measure the onset, progression and impact of HIV-related comorbid disease and provide a platform for critically important translational studies of pathogenesis in cardiovascular disease (CVD), human papillomavirus (HPV), aging, and HIV-disease progression. As these two highly successful and critically important cohorts merge, the Bronx Clinical Research Site (CRS) will support the new Combined Cohort Study (CCS) in an effort to understand and advance the study of HIV infection and its treatment, with a focus on HIV-related comorbidities and aging with HIV. The Bronx CRS will provide scientific leadership to the CCS in three specific areas: CVD, microbiome studies, and HPV infection and disease. In particular, the Bronx CRS will provide innovative scientific leadership in studying CVD among PLWH with a longitudinal echocardiography study and a high-caliber Echo Reading Center, including cutting-edge cardiovascular imaging, and the study of CVD in relation to inflammatory markers, metabolomics, and microbiome among PLWH. The Bronx CRS will continue to follow our large numbers of well-characterized persons living with and without HIV, as well as recruit primarily racial and ethnic minority men and women with or at-risk for HIV to reflect our local NYC HIV epidemic, thus allowing us to investigate the impact of age, sex, race/ethnicity, and health disparities on HIV disease progression and its relation to comorbid illnesses across the lifespan. The value of these studies goes far beyond the United States, to inform the global HIV epidemic, and care of PLWH.