Excellence in Research for Emerging and Reemerging Diseases of Public Health Interest in Colombia at the National Institute of Health

杰出的公共卫生新发和再发疾病研究 国家卫生研究所对哥伦比亚的兴趣 项目摘要/摘要 这是RFA-GH-20-003下的一个多项目提案，在 哥伦比亚。拟议的研究将有助于预防、检测、应对和 遏制传染病对公共卫生造成的威胁，并减少由此产生的 哥伦比亚的负担和残疾。在第一年，我们提出了三个相关的研究项目 针对哥伦比亚的传染病，其最终目标是改善公共卫生。 这些项目集中在急性发热病(AFI)和相关方面的研究。 指导公共卫生干预并发现新出现的威胁，以更好地定义负担、风险、 以及干预措施的有效性，以减轻其影响。总的来说，这三个项目将 最终通过以下途径解决动物-人类界面上人畜共患疾病的研究问题 应用“同一健康”方法更好地了解流行病学并及早改善 急性发热性疾病的检测和急性发热性疾病的相关方面 热带地方性疾病，包括(A)寄生虫病(锥虫、利什曼原虫、 隐孢子虫、贾第鞭毛虫)，(B)卫生保健相关感染(大肠杆菌、克雷伯氏菌、 不动杆菌、金黄色念珠菌等)，(C)腹泻疾病和肠道感染 (轮状病毒、腺病毒、星状病毒、诺如病毒、沙门氏菌、志贺氏菌、弯曲杆菌、弧菌 (D)病毒性疾病(冠状病毒、肝炎、流感、虫媒病毒、麻疹、 风疹、狂犬病、黄热病和其他出血热、阿拉伯病毒)。 我们研究的总体目标是： ·开展和监测流行病学、临床和实验室项目、监测、 和研究哥伦比亚的重要疾病，包括但不限于下列活动 解决急性发热性疾病、抗菌素耐药性和医院获得性感染； 呼吸道感染、流感、肠道疾病和其他公共卫生威胁 ·将研究活动的结果纳入可操作的疾病检测， 哥伦比亚的预防、应对或控制计划，加强公共卫生 《全球卫生安全议程》中概述的能力，以及加强地方 劳动力能力和在全国和整个区域传播调查结果。 我们最初(第一年)的重点将是制定和实施三个项目： ·项目1：开展研究以确定急性发烧的病因和负担 哥伦比亚疾病(AFI)； ·项目2：开展研究以确定抗菌剂的使用范围和特性 哥伦比亚部分病原体从与急性热病相关的疾病中恢复抗药性 研究(AMR)；以及 ·项目3：加强昆虫学研究(昆虫学)。 我们的总体目标是开发一个灵活和适应性强的传染病研究平台，以 在新冠肺炎上探索AFI和新出现的大流行威胁的方方面面，并使用 指导干预措施和改进公共卫生实践的调查结果。

Excellence in Research for Emerging and Reemerging Diseases of Public Health Interest in Colombia at the National Institute of Health Project Summary / Abstract This is a multiproject proposal under RFA-GH-20-003, Conducting Public Health Research in Colombia. The proposed research will contribute to the prevention, detection, response and containment of public health threats posed by infectious diseases and to reduce the resulting burden and disabilities in Colombia. In Year 1 we propose three research projects on relevant infectious diseases for Colombia, with the ultimate goal of improving public health. These projects are centered on research of acute febrile illness (AFI) and related aspects to guide public health interventions and detect emerging threats to better define the burden, risk, and effectiveness of interventions to mitigate their impact. Collectively, the three projects will ultimately address research questions on zoonotic diseases at the animal-human interface through apply a “One Health” approach to better understand the epidemiology and to improve early detection of acute febrile illness and associated aspects of acute febrile illness in the conext of endemic tropical diseases including those of (a) parasitic diseases (Trypanosoma, Leishmania, Cryptosporidium, Giardia), (b) health care associated infections (Escherichia coli, Klebsiella, Acinetobacter, Candida auris and others), (c) diarrheal diseases and enteric infections (rotavirus, adenovirus, astrovirus, norovirus, Salmonella, Shigella, Campylobacter, Vibrio cholerae), and (d) viral diseases (coronaviruses, hepatitis, influenza, arboviruses, measles, rubella, rabies, yellow fever and other hemorrhagic fevers, arenaviruses). Our overall aims for our research are to: • Conduct and monitor epidemiologic, clinical, and laboratory-based projects, surveillance, and research of important diseases in Colombia including, but not limited to, activities to address acute febrile illness, antimicrobial resistance and hospital acquired infections, respiratory infections and influenza, enteric illnesses, and other public health threats • Incorporate the results of research activities into operational disease detection, prevention, and response or control programs in Colombia, strengthen public health capacity as outlined in the Global Health Security Agenda, and the strengthening of local workforce capacity and dissemination of findings nationally and across the region. Our initial focus (Year 1) will be on the development and implementation of three projects: • Project 1: Conduct research to determine the etiologies and burden of acute febrile illness in Colombia (AFI); • Project 2: Conduct research to determine the extent and characteristics of antimicrobial resistance in selected pathogens in Colombia recovered from acute febrile illness-related research (AMR); and, • Project 3: Strengthening of Entomological Research (Entomology). Our overall goal is to develop a flexible and adaptable infectious disease research platform to explore all aspects of AFI and emerging pandemic threats such at COVID-19 and use the findings to guide interventions and improve public health practice.