Microelectrode Array Insertion System using Ultrasonic Vibration to Improve Insertion Mechanics, Reduce Tissue Dimpling and Trauma, and Improve Placement Precision in the Neocortex
使用超声波振动的微电极阵列插入系统改善插入力学,减少组织凹陷和创伤,并提高新皮质的放置精度
基本信息
- 批准号:10268984
- 负责人:
- 金额:$ 142.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AmputeesAnimal ModelBRAIN initiativeBrainCaliberCell DeathChronicCicatrixClinicalCollaborationsCommunicationCommunitiesComplexCouplingDataDevelopmentDevicesDura MaterElectrodesEngineeringEquipment MalfunctionExhibitsFeedbackForeign BodiesFrequenciesGoalsHemorrhageHumanImageImplantImplantation procedureImplanted ElectrodesIncidenceIndividualInflammationLocationMagnetic Resonance ImagingManualsMarketingMechanicsMedicalMedical ResearchMethodsMicroelectrodesMotionNeocortexNeurologicNeuronsNeurosciences ResearchOperative Surgical ProceduresOutcomeParaplegiaPatient CarePenetrationPeripheral Nervous SystemPhasePolymersPropertyProprioceptionProsthesisRattusResolutionRiskSalesSensoryShapesSiliconSiteSmall Business Innovation Research GrantSpeedStructureSurfaceSystemTechnologyTestingTissuesTraumaTungstenUltrafineUltrasonicsValidationWorkbasebrain machine interfacecarbon fibercommercializationcraniumdensitydesignextracellularflexibilitygraspimplantationimprovedimproved outcomein vivoinnovationmillimeterminimally invasivemotor controlneural implantneurotransmissionnonhuman primatenovelpre-clinicalpreservationprosthesis controlrelating to nervous systemresponsesuccesstissue traumatooltwo-photonverification and validationvibration
项目摘要
This Phase II SBIR further develops and tests a system that employs ultrasonic vibration to improve the
insertion mechanics for multichannel penetrating electrode arrays. This proposal is in response to PA-18-871
BRAIN Initiative: Development, Optimization, and Validation of Novel Tools and Technologies for
Neuroscience Research – including ‘Iterative refinement of such tools and technologies with the end-user
community’. The long-term goal of Actuated Medical, Inc. is to develop technology enabling accurate
placement of penetrating neural electrode arrays at target locations with minimal tissue trauma and
displacement, ultimately paving the way for clinical use of neural implants.
Penetrating neural implants provide direct access to extracellular neural signals across the central and
peripheral nervous systems with both high temporal and spatial resolution. Unfortunately, the implantation of
neural electrode arrays, commonly comprised of numerous closely spaced shanks, applies forces to neural
tissue resulting in significant compression (dimpling), prohibiting uniform shank insertion, and increasing the
risk of trauma, bleeding and inflammation at the implant site. These issues can increase the chronic foreign
body response (FBR) leading to neural cell death, glial scaring, and device failure. Phase I demonstrated the
ability to releasably grip and deliver ultrasonic vibration to a range of commercially available implant types,
including floating-style arrays, resulting in reductions of insertion force and surface dimpling in bench studies of
up to 80-90% for most implants tested. In vivo, ultrasonic vibration significantly reduced brain surface dimpling
(~50%, p<0.01) and exhibited evidence of reduced bleeding, while preserving device function as evidenced by
post implant neural recordings. Furthermore, preliminary work suggests significant potential for the ultrasonic
vibration to improve insertion of ultrafine (8-15 µm) microwire arrays, as well as NeuroNexus’ Matrix platform
arrays, one of the most delicate and complicated commercially-available implants. This Phase II SBIR expands
use of the NeuralGlider inserter for inserting complex, fragile, and flexible penetrating neural electrode arrays
using ultrasonic vibration to reduce insertion force, brain surface dimpling, tissue damage, and bleeding. The
project uses a unique multi-institutional collaboration to obtain scientific data, supporting the benefits of the
NeuralGlider insertion technology. Phase II hypothesis: Ultrasonic micro-vibration improves insertion accuracy
and success, reduces insertion trauma, and improves recording outcomes for penetrating neural electrode
arrays. Specific Aims: Aim 1 - Evaluate implantation trauma and inflammation response through 2-photon
imaging and magnetic resonance imaging. Aim 2 - Demonstrate efficacy of NeuralGlider insertion approach
for ultra-fine, ultra-high-density electrode array designs. Aim 3 - Integrate end user feedback, design upgrades
for coupling options, and conduct Verification and Validation. Aim 4 - Demonstrate improved outcomes with
micro-vibrated insertion.
第二阶段SBIR进一步开发和测试了采用超声波振动的系统,以改善
多通道穿透电极阵列的插入机构。本提案是对PA-18-871的回应
大脑计划:新工具和技术的开发、优化和验证
神经科学研究--包括与最终用户对这些工具和技术进行迭代改进
“社区”。Actuated Medical,Inc.的长期目标是开发能够实现准确
将穿透性神经电极阵列放置在组织损伤最小的靶点位置
置换,最终为神经植入物的临床应用铺平了道路。
穿透性神经植入物提供直接访问细胞外神经信号的中央和
具有高时间和空间分辨率的外周神经系统。不幸的是,植入
神经电极阵列通常由许多紧密间隔的小腿组成,将力施加到神经
导致显著压缩(凹陷)的组织,阻止均匀的小腿插入,并增加
植入部位有受伤、出血和发炎的风险。这些问题会增加慢性外来者
身体反应(FBR)导致神经细胞死亡、神经胶质细胞惊吓和设备故障。第一阶段演示了
能够可释放地夹持并向一系列商业可获得的植入物类型传递超声波振动,
包括浮动式阵列,从而减少了插入力和表面凹陷的台架研究
对于大多数测试的植入物,高达80%-90%。在体内,超声波振动显著减少了大脑表面的凹陷
(~50%,p<;0.01),并显示出血减少的证据,同时保留了装置的功能,如以下所示
植入后的神经记录。此外,初步工作表明,超声波具有很大的潜力
振动以改进超细(8-15微米)微线阵列以及NeuroNexus的矩阵平台的插入
阵列,最精致和复杂的商业植入物之一。此第二阶段SBIR扩展
使用NeuralGlider插入器插入复杂、脆弱和灵活的穿透性神经电极阵列
使用超声波振动来减少插入力、脑表面凹陷、组织损伤和出血。这个
该项目使用独特的多机构协作来获取科学数据,支持
NeuralGlider插入技术。阶段II假设:超声波微振动提高插入精度
和成功,减少插入创伤,并改善穿透神经电极的记录结果
数组。具体目标:目标1-通过双光子评估植入创伤和炎症反应
成像和磁共振成像。目标2-演示NeuralGlider插入方法的有效性
用于超精细、超高密度的电极阵列设计。目标3-整合最终用户反馈、设计升级
用于联轴器选项,并进行验证和确认。目标4-展示更好的结果
微振动插入。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Maureen L. Mulvihill其他文献
Maureen L. Mulvihill的其他文献
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{{ truncateString('Maureen L. Mulvihill', 18)}}的其他基金
Development of an Acoustic Implant Protection System to Improve Performance and Longevity of Neural Interfaces
开发声学植入保护系统以提高神经接口的性能和寿命
- 批准号:
10552838 - 财政年份:2022
- 资助金额:
$ 142.35万 - 项目类别:
Development of an Acoustic Implant Protection System to Improve Performance and Longevity of Neural Interfaces
开发声学植入保护系统以提高神经接口的性能和寿命
- 批准号:
10763996 - 财政年份:2022
- 资助金额:
$ 142.35万 - 项目类别:
ICORPs Support for Development of an Acoustic Implant Protection System to Improve Performance and Longevity of Neural Interfaces
ICORP 支持声学植入保护系统的开发,以提高神经接口的性能和寿命
- 批准号:
10739498 - 财政年份:2022
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Expansion of Engineering and Testing for 'Locally Targeted Acoustic Neuropathy Medication Delivery System for Pain Relief without Large Systemic Doses and Side Effects'
扩大“用于缓解疼痛且无大全身剂量和副作用的局部靶向听神经病药物输送系统”的工程和测试
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9933278 - 财政年份:2019
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- 批准号:
10438928 - 财政年份:2018
- 资助金额:
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Active Disposable Cap for Endoscope Tip Stabilization and Complete Visualization and Dissection of Serrated Sessile Polyps
用于内窥镜尖端稳定以及锯齿状无蒂息肉的完整可视化和解剖的主动一次性帽
- 批准号:
9925224 - 财政年份:2018
- 资助金额:
$ 142.35万 - 项目类别:
Neural Implant Insertion System using Ultrasonic Vibration to Reduce Tissue Dimpling and Improve Insertion Precision of Floating Arrays in the Neocortex
使用超声波振动的神经植入物插入系统减少组织凹陷并提高新皮质中浮动阵列的插入精度
- 批准号:
9565293 - 财政年份:2018
- 资助金额:
$ 142.35万 - 项目类别:
Active Disposable Cap for Endoscope Tip Stabilization and Complete Visualization and Dissection of Serrated Sessile Polyps
用于内窥镜尖端稳定以及锯齿状无蒂息肉的完整可视化和解剖的主动一次性帽
- 批准号:
10708957 - 财政年份:2018
- 资助金额:
$ 142.35万 - 项目类别:
Microelectrode Array Insertion System using Ultrasonic Vibration to Improve Insertion Mechanics, Reduce Tissue Dimpling and Trauma, and Improve Placement Precision in the Neocortex
使用超声波振动的微电极阵列插入系统改善插入力学,减少组织凹陷和创伤,并提高新皮质的放置精度
- 批准号:
10021212 - 财政年份:2018
- 资助金额:
$ 142.35万 - 项目类别:
Active Disposable Cap for Endoscope Tip Stabilization and Complete Visualization and Dissection of Serrated Sessile Polyps
用于内窥镜尖端稳定以及锯齿状无蒂息肉的完整可视化和解剖的主动一次性帽
- 批准号:
10611153 - 财政年份:2018
- 资助金额:
$ 142.35万 - 项目类别:
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