ICORPs Support for Development of an Acoustic Implant Protection System to Improve Performance and Longevity of Neural Interfaces
ICORP 支持声学植入保护系统的开发,以提高神经接口的性能和寿命
基本信息
- 批准号:10739498
- 负责人:
- 金额:$ 5.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-05 至 2023-06-30
- 项目状态:已结题
- 来源:
- 关键词:AcousticsAmputeesAstrocytesBRAIN initiativeBlood - brain barrier anatomyBrainCentral Nervous SystemCerebrumChemicalsChronicCicatrixClinicalDetectionDevelopmentDevicesDiseaseEffectivenessElectrodesElectronicsEnvironmentEquilibriumEquipment MalfunctionFeedbackForeign BodiesImmune responseImmunityImplantImplanted ElectrodesInjuryLifeLongevityMarketingMeasurableMedicalMicroelectrodesMicrogliaModelingNeuronsNeurophysiology - biologic functionParaplegiaPenetrationPerformancePeripheral Nervous SystemPhasePhysiologic pulseProsthesisResolutionSignal TransductionSiteSmall Business Innovation Research GrantSystemTechnologyTestingTherapeuticThinnessTimeTissuesTransducersTranslationsbrain machine interfacecommercializationcostdesignelectric impedanceglial activationhealingimplantationimprovedinterestmotor controlnervous system disorderneuralneural implantneuroprosthesisneuroprotectionneurotransmissionneurotrophic factornext generationportabilitypre-clinicalpreclinical studypreventprototyperesponseside effectultrasoundverification and validation
项目摘要
This ICORPs project expands market understanding and conducts extensive customer discovery for the
Acoustic Implant Protection system for use with Neural Implants.
Original Abstract: This SBIR Fast-track finalizes, tests, and commercializes the Acoustic Implant Protection
(AIP) system, which uses the application of precision acoustic fields to penetrating neural implants to prevent
electrode impedance rise and improve implant longevity. This submission is in response to: Notice of Special
Interest (NOSI): NOT-MH-21-125 Translation of BRAIN Initiative Technologies to the Marketplace.
Problem to be solved: Chronic neural implants hold great potential for illuminating features of neural function,
treating neurological disorders, and enabling the next generation of brain-machine interface-based
neuroprosthetics. Penetrating microelectrode arrays provide direct access to neural signals with high
temporospatial resolution. However, their preclinical and clinical viability are limited by their poor longevity and
variability in functionality due to the immune response or foreign body response (FBR). The FBR can cause
glial scarring and neural cell loss near the electrode sites of penetrating arrays over a period of several weeks,
which are leading causes of signal recording losses through both electrical isolation and spatial distancing
effects. The FBR begins with electrode insertion, when damage to the blood brain barrier activates astrocytes
and microglia. Although ‘soft’ electrode materials, thinner shanks, and floating arrays have been developed to
minimize the mismatch between brain and implant, none of these have demonstrated sufficient recording life
and immunity to the FBR. Exogenous chemical means have been used to directly suppress the FBR, and
have yielded positive results to varying degrees, but limitations of effectiveness, high costs, and/or undesirable
side-effects still exist. A simple approach is needed to mitigate FBR for both preclinical and clinical use.
Solution: Sub-threshold therapeutic ultrasound has recently been shown to have protective and healing effects
in models of cerebral disease and injury, through promotion of neurotrophic factors. AMI successfully
leveraged this principle in an R21 study evaluating low-intensity pulsed ultrasound (LIPUS) to mitigate the
microglia response and improve longevity of neural interfaces. Product: This Fast-track delivers an AIP
system for preclinical use with a reusable (releasable) annular transducer that delivers LIPUS to produce a
neuro-protective environment around implanted microelectrodes.
Phase I: Aim 1 – Electronics/System Adaptation for Preclinical Study. Aim 2 – Confirm ultrasound parameters
for AIP annulus that safely stimulate cortical tissues comparable to Alpha design from R21.
Phase I to Phase II Go-no-go. Portable, reusable AIP prototype produces measurable improvement in neural
signal longevity over 6 weeks in preclinical microelectrode study. Positive feedback from potential end users.
Aim 3– Integrate End User Design Feedback and Conduct Verification and Validation. Aim 4 – Optimize
stimulation intervals for neural interface performance (SNR, unit detection) and demonstrate additional neuro-
protective effects (glial cell activation, E-I balance) of LIPUS in preclinical studies.
该ICORPs项目扩大了对市场的了解,并为该项目进行了广泛的客户发现
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Maureen L. Mulvihill其他文献
Maureen L. Mulvihill的其他文献
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{{ truncateString('Maureen L. Mulvihill', 18)}}的其他基金
Development of an Acoustic Implant Protection System to Improve Performance and Longevity of Neural Interfaces
开发声学植入保护系统以提高神经接口的性能和寿命
- 批准号:
10552838 - 财政年份:2022
- 资助金额:
$ 5.5万 - 项目类别:
Development of an Acoustic Implant Protection System to Improve Performance and Longevity of Neural Interfaces
开发声学植入保护系统以提高神经接口的性能和寿命
- 批准号:
10763996 - 财政年份:2022
- 资助金额:
$ 5.5万 - 项目类别:
Expansion of Engineering and Testing for 'Locally Targeted Acoustic Neuropathy Medication Delivery System for Pain Relief without Large Systemic Doses and Side Effects'
扩大“用于缓解疼痛且无大全身剂量和副作用的局部靶向听神经病药物输送系统”的工程和测试
- 批准号:
9933278 - 财政年份:2019
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Active Disposable Cap for Endoscope Tip Stabilization and Complete Visualization and Dissection of Serrated Sessile Polyps
用于内窥镜尖端稳定以及锯齿状无蒂息肉的完整可视化和解剖的主动一次性帽
- 批准号:
10438928 - 财政年份:2018
- 资助金额:
$ 5.5万 - 项目类别:
Active Disposable Cap for Endoscope Tip Stabilization and Complete Visualization and Dissection of Serrated Sessile Polyps
用于内窥镜尖端稳定以及锯齿状无蒂息肉的完整可视化和解剖的主动一次性帽
- 批准号:
9925224 - 财政年份:2018
- 资助金额:
$ 5.5万 - 项目类别:
Neural Implant Insertion System using Ultrasonic Vibration to Reduce Tissue Dimpling and Improve Insertion Precision of Floating Arrays in the Neocortex
使用超声波振动的神经植入物插入系统减少组织凹陷并提高新皮质中浮动阵列的插入精度
- 批准号:
9565293 - 财政年份:2018
- 资助金额:
$ 5.5万 - 项目类别:
Active Disposable Cap for Endoscope Tip Stabilization and Complete Visualization and Dissection of Serrated Sessile Polyps
用于内窥镜尖端稳定以及锯齿状无蒂息肉的完整可视化和解剖的主动一次性帽
- 批准号:
10708957 - 财政年份:2018
- 资助金额:
$ 5.5万 - 项目类别:
Microelectrode Array Insertion System using Ultrasonic Vibration to Improve Insertion Mechanics, Reduce Tissue Dimpling and Trauma, and Improve Placement Precision in the Neocortex
使用超声波振动的微电极阵列插入系统改善插入力学,减少组织凹陷和创伤,并提高新皮质的放置精度
- 批准号:
10021212 - 财政年份:2018
- 资助金额:
$ 5.5万 - 项目类别:
Microelectrode Array Insertion System using Ultrasonic Vibration to Improve Insertion Mechanics, Reduce Tissue Dimpling and Trauma, and Improve Placement Precision in the Neocortex
使用超声波振动的微电极阵列插入系统改善插入力学,减少组织凹陷和创伤,并提高新皮质的放置精度
- 批准号:
10268984 - 财政年份:2018
- 资助金额:
$ 5.5万 - 项目类别:
Active Disposable Cap for Endoscope Tip Stabilization and Complete Visualization and Dissection of Serrated Sessile Polyps
用于内窥镜尖端稳定以及锯齿状无蒂息肉的完整可视化和解剖的主动一次性帽
- 批准号:
10611153 - 财政年份:2018
- 资助金额:
$ 5.5万 - 项目类别:
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