Non-neuronal ATP: regulation of release and action in the bladder

非神经元 ATP：膀胱中释放和作用的调节

• 批准号: nhmrc : 527502
• 负责人: A/Pr Kylie Mansfield
• 金额: $ 30.11万
• 依托单位: Bond University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/non-neuronal-atp-action-bladder/77917
• 关键词: Non; neuronal; ATP; regulation; release

Incontinence disorders are costly and debilitating. How the bladder signals the normal sensation of fullness as well as the urgent need to void urine (urgency) is still not fully understood. The signaling molecule ATP is released during bladder stretch. Using animal and human bladder, we will study how the bladder lining is involved in this signaling process, by measuring how bladder chemicals interact with stretch to modulate ATP release, and how ATP can influence nerve impulses to the brain.

尿失禁是昂贵和虚弱的。膀胱如何发出正常的饱腹感以及迫切需要排尿的信号（紧迫性）仍未完全了解。信号分子ATP在膀胱伸展过程中释放。使用动物和人类膀胱，我们将通过测量膀胱化学物质如何与拉伸相互作用来调节ATP释放，以及ATP如何影响神经冲动到大脑，来研究膀胱内膜如何参与这一信号传递过程。