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Imaging Human Brain Function with Minimal Mobility Restrictions

在最小的移动限制下对人脑功能进行成像

基本信息

批准号：
10240647
负责人：
MICHAEL GARWOOD
金额：
$ 149.18万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-30 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10240647
关键词：
Address Animal Model Architecture Automobile Driving BRAIN initiative Barium Behavior Brain Brain imaging Clinical Cognition Complex Computer software Copper Diagnosis Discipline Disease Environment Freedom Frequencies Functional Magnetic Resonance Imaging Goals Grant Head Health Helium High temperature of physical object Human Human body Image Imaging Techniques Imaging technology Immobilization Infrastructure Injury Institution Liquid substance Magnetic Resonance Imaging Mental disorders Methods Monoclonal Antibody R24 Motion Motor Movement Neurodegenerative Disorders Neurons Neurosciences Neurosciences Research Oxides Parkinsonian Disorders Patients Persons Pilot Projects Planet Earth Population Positioning Attribute Posture Research Personnel Resolution Shoulder Signal Transduction Site Stroke Structure Study Subject Supination System Technology Testing Time Traumatic Brain Injury Tube Variant Weight base design developmental disease digital feeding high resolution imaging human imaging image reconstruction imaging approach imaging modality imaging system interest irradiation light weight magnetic field motor deficit multidisciplinary portability prototype radio frequency reconstruction relating to nervous system spatiotemporal tool

项目摘要

Magnetic resonance imaging (MRI), by offering the sole means of imaging human brain structure and activity with high spatial resolution, has evolved into an indispensable tool for studying brain function in health and disease. It is uniquely suited to examining the neural basis of higher order behaviors and cognition, as well as neurodegenerative and developmental disorders, for which animal models are of limited applicability. Yet, because of current experimental limitations, there is wide range of subjects and human behaviors that are completely inaccessible by MRI techniques. MRI currently depends on large, expensive, and fixed scanners in which subjects must remain motionless for long periods of time within a confined horizontal space. Thus any behavior involving motion, and especially those involving the upright real-time interaction with objects in natural environments, cannot be studied. Such studies are of enormous scientific interest, for example, in understanding the neuronal basis of motor planning, but also of considerable practical and clinical importance in order to eventually understand and address the motor deficits associated with injury, stroke, or disease which preclude everyday behaviors as important as feeding and reaching. Of particular relevance in this regard is the large population of people with limited ambulatory or vestibular function or difficulty in maintaining posture or smooth movements for which the requirements of remaining motionless in a horizontal space preclude MRI. There is thus an urgent need for a brain imaging technology that is more portable and less restricting than current MRI scanners. One way to address these issues is to decrease the size of the MRI magnet to make a head-only system which does not confine the body, but this approach leads to drastically reduced static field (B0) homogeneity which, with current technologies, precludes high resolution imaging. Now, with the support from BRAIN Initiative grant R24 MH105998, we have addressed the problem by developing new hardware, as well as new acquisition and reconstruction methods, capable of producing high quality brain images despite extreme B0 inhomogeneity. The goal of this U01 project is to build upon these efforts by designing, building, and validating the first-ever human MRI scanner requiring only the head to be inside the magnet bore and having a large window for viewing outside the magnet bore. The small size, weight, and power requirements of this 1.5 Tesla MRI system will enable it to be transported and sited almost anywhere in the world and will be able to bring the magnet to the subject rather than the other way around. To achieve this, a team of leading experts from multiple disciplines and institutions has been assembled. The hardware and software components of this revolutionary MRI system will be constructed and debugged in the first 2 years of the project, the system will be assembled and tested in years 3- 4, and finally in year 5, the MRI system will be piloted in a first of its kind study of motor coordination and planning during natural reaching behaviors.

磁共振成像（MRI），通过提供成像人脑的唯一手段

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Ethical Issues Posed by Field Research Using Highly Portable and Cloud-Enabled Neuroimaging.

DOI：
10.1016/j.neuron.2020.01.041
发表时间：
2020-03-04
期刊：
Neuron
影响因子：
16.2
作者：
Shen FX;Wolf SM;Gonzalez RG;Garwood M
通讯作者：
Garwood M

Two-dimensional frequency-swept pulse with resilience to both B1 and B0 inhomogeneity.

二维扫频脉冲具有抗 B1 和 B0 不均匀性的能力。

DOI：
10.1016/j.jmr.2018.12.017
发表时间：
2019
期刊：
Journal of magnetic resonance (San Diego, Calif. : 1997)
影响因子：
0
作者：
Mullen,Michael;Kobayashi,Naoharu;Garwood,Michael
通讯作者：
Garwood,Michael

Ultra-low frequency EPR using longitudinal detection and fictitious-field modulation.

DOI：
10.1016/j.jmr.2020.106855
发表时间：
2020-12
期刊：
Journal of magnetic resonance (San Diego, Calif. : 1997)
影响因子：
0
作者：
Tang X;Suddarth S;Qian G;Garwood M
通讯作者：
Garwood M

Accelerated imaging with segmented 2D pulses using parallel imaging and virtual coils.

使用并行成像和虚拟线圈通过分段二维脉冲加速成像。

DOI：
10.1016/j.jmr.2019.07.001
发表时间：
2019
期刊：
Journal of magnetic resonance (San Diego, Calif. : 1997)
影响因子：
0
作者：
Mullen,Michael;Gutierrez,Alexander;Kobayashi,Naoharu;Haupt,Jarvis;Garwood,Michael
通讯作者：
Garwood,Michael

Expanding access to magnetic resonance education through open-source web tutorials.

通过开源网络教程扩大磁共振教育的范围。