Imaging Human Brain Function with Minimal Mobility Restrictions
在最小的移动限制下对人脑功能进行成像
基本信息
- 批准号:10240647
- 负责人:
- 金额:$ 149.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-30 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAnimal ModelArchitectureAutomobile DrivingBRAIN initiativeBariumBehaviorBrainBrain imagingClinicalCognitionComplexComputer softwareCopperDiagnosisDisciplineDiseaseEnvironmentFreedomFrequenciesFunctional Magnetic Resonance ImagingGoalsGrantHeadHealthHeliumHigh temperature of physical objectHumanHuman bodyImageImaging TechniquesImaging technologyImmobilizationInfrastructureInjuryInstitutionLiquid substanceMagnetic Resonance ImagingMental disordersMethodsMonoclonal Antibody R24MotionMotorMovementNeurodegenerative DisordersNeuronsNeurosciencesNeurosciences ResearchOxidesParkinsonian DisordersPatientsPersonsPilot ProjectsPlanet EarthPopulationPositioning AttributePostureResearch PersonnelResolutionShoulderSignal TransductionSiteStrokeStructureStudy SubjectSupinationSystemTechnologyTestingTimeTraumatic Brain InjuryTubeVariantWeightbasedesigndevelopmental diseasedigitalfeedinghigh resolution imaginghuman imagingimage reconstructionimaging approachimaging modalityimaging systeminterestirradiationlight weightmagnetic fieldmotor deficitmultidisciplinaryportabilityprototyperadio frequencyreconstructionrelating to nervous systemspatiotemporaltool
项目摘要
Magnetic resonance imaging (MRI), by offering the sole means of imaging human brain
structure and activity with high spatial resolution, has evolved into an indispensable tool for
studying brain function in health and disease. It is uniquely suited to examining the neural basis
of higher order behaviors and cognition, as well as neurodegenerative and developmental
disorders, for which animal models are of limited applicability. Yet, because of current
experimental limitations, there is wide range of subjects and human behaviors that are
completely inaccessible by MRI techniques. MRI currently depends on large, expensive, and
fixed scanners in which subjects must remain motionless for long periods of time within a
confined horizontal space. Thus any behavior involving motion, and especially those involving
the upright real-time interaction with objects in natural environments, cannot be studied. Such
studies are of enormous scientific interest, for example, in understanding the neuronal basis of
motor planning, but also of considerable practical and clinical importance in order to eventually
understand and address the motor deficits associated with injury, stroke, or disease which
preclude everyday behaviors as important as feeding and reaching. Of particular relevance in
this regard is the large population of people with limited ambulatory or vestibular function or
difficulty in maintaining posture or smooth movements for which the requirements of remaining
motionless in a horizontal space preclude MRI. There is thus an urgent need for a brain imaging
technology that is more portable and less restricting than current MRI scanners. One way to
address these issues is to decrease the size of the MRI magnet to make a head-only system
which does not confine the body, but this approach leads to drastically reduced static field (B0)
homogeneity which, with current technologies, precludes high resolution imaging. Now, with the
support from BRAIN Initiative grant R24 MH105998, we have addressed the problem by
developing new hardware, as well as new acquisition and reconstruction methods, capable of
producing high quality brain images despite extreme B0 inhomogeneity. The goal of this U01
project is to build upon these efforts by designing, building, and validating the first-ever human
MRI scanner requiring only the head to be inside the magnet bore and having a large window
for viewing outside the magnet bore. The small size, weight, and power requirements of this 1.5
Tesla MRI system will enable it to be transported and sited almost anywhere in the world and
will be able to bring the magnet to the subject rather than the other way around. To achieve this,
a team of leading experts from multiple disciplines and institutions has been assembled. The
hardware and software components of this revolutionary MRI system will be constructed and
debugged in the first 2 years of the project, the system will be assembled and tested in years 3-
4, and finally in year 5, the MRI system will be piloted in a first of its kind study of motor
coordination and planning during natural reaching behaviors.
磁共振成像(MRI),通过提供成像人脑的唯一手段
项目成果
期刊论文数量(11)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Ethical Issues Posed by Field Research Using Highly Portable and Cloud-Enabled Neuroimaging.
- DOI:10.1016/j.neuron.2020.01.041
- 发表时间:2020-03-04
- 期刊:
- 影响因子:16.2
- 作者:Shen FX;Wolf SM;Gonzalez RG;Garwood M
- 通讯作者:Garwood M
Two-dimensional frequency-swept pulse with resilience to both B1 and B0 inhomogeneity.
二维扫频脉冲具有抗 B1 和 B0 不均匀性的能力。
- DOI:10.1016/j.jmr.2018.12.017
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Mullen,Michael;Kobayashi,Naoharu;Garwood,Michael
- 通讯作者:Garwood,Michael
Ultra-low frequency EPR using longitudinal detection and fictitious-field modulation.
- DOI:10.1016/j.jmr.2020.106855
- 发表时间:2020-12
- 期刊:
- 影响因子:0
- 作者:Tang X;Suddarth S;Qian G;Garwood M
- 通讯作者:Garwood M
Accelerated imaging with segmented 2D pulses using parallel imaging and virtual coils.
使用并行成像和虚拟线圈通过分段二维脉冲加速成像。
- DOI:10.1016/j.jmr.2019.07.001
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Mullen,Michael;Gutierrez,Alexander;Kobayashi,Naoharu;Haupt,Jarvis;Garwood,Michael
- 通讯作者:Garwood,Michael
Expanding access to magnetic resonance education through open-source web tutorials.
通过开源网络教程扩大磁共振教育的范围。
- DOI:10.1002/nbm.5109
- 发表时间:2024
- 期刊:
- 影响因子:2.9
- 作者:Tong,Gehua;Ananth,Rishi;VaughanJr,JohnThomas;Geethanath,Sairam
- 通讯作者:Geethanath,Sairam
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MICHAEL GARWOOD其他文献
MICHAEL GARWOOD的其他文献
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{{ truncateString('MICHAEL GARWOOD', 18)}}的其他基金
Angular Dependency of T1 Relaxation Time in Cerebral White Matter in Ultrahigh Field MRI
超高场 MRI 脑白质 T1 弛豫时间的角度依赖性
- 批准号:
9983056 - 财政年份:2019
- 资助金额:
$ 149.18万 - 项目类别:
Imaging Human Brain Function with Minimal Mobility Restrictions: SUPPLEMENT: Administrative Supplement for Research on Bioethical Issues
以最小的移动限制对人脑功能进行成像:补充:生物伦理问题研究的行政补充
- 批准号:
9928254 - 财政年份:2017
- 资助金额:
$ 149.18万 - 项目类别:
Imaging Brain Function in Real World Environments & Populations with Portable MRI
真实世界环境中的大脑功能成像
- 批准号:
8822705 - 财政年份:2014
- 资助金额:
$ 149.18万 - 项目类别:
Imaging Brain Function in Real World Environments & Populations with Portable MRI
真实世界环境中的大脑功能成像
- 批准号:
8935941 - 财政年份:2014
- 资助金额:
$ 149.18万 - 项目类别:
VALIDATION OF MR TECH OF THERAPEUTIC EFFICACY FOR DRUG DISCOV IN ALZH DISEASE
MR 技术对 ALZH 疾病药物发现治疗效果的验证
- 批准号:
8362867 - 财政年份:2011
- 资助金额:
$ 149.18万 - 项目类别:
SWIFT DETECTION OF SPIO LABELED STEM CELLS GRAFTED IN THE MYOCARDIUM
快速检测移植到心肌中的 SPIO 标记干细胞
- 批准号:
8362855 - 财政年份:2011
- 资助金额:
$ 149.18万 - 项目类别:
DEVELOP OF ANTIBODY FRAGM AS CONTR AGT FOR MRI OF ALZH?S DIS AMYLOID PLAQUES
开发抗体片段作为 ALZH 淀粉样斑块 MRI 的对照 AGT
- 批准号:
8362868 - 财政年份:2011
- 资助金额:
$ 149.18万 - 项目类别:
DEVELOP OF ANTIBODY FRAGM AS CONTR AGT FOR MRI OF ALZH?S DIS AMYLOID PLAQUES
开发抗体片段作为 ALZH 淀粉样斑块 MRI 的对照 AGT
- 批准号:
8170473 - 财政年份:2010
- 资助金额:
$ 149.18万 - 项目类别:
SWIFT DETECTION OF SPIO LABELED STEM CELLS GRAFTED IN THE MYOCARDIUM
快速检测移植到心肌中的 SPIO 标记干细胞
- 批准号:
8170460 - 财政年份:2010
- 资助金额:
$ 149.18万 - 项目类别:
VALIDATION OF MR TECH OF THERAPEUTIC EFFICACY FOR DRUG DISCOV IN ALZH DISEASE
MR 技术对 ALZH 疾病药物发现治疗效果的验证
- 批准号:
8170472 - 财政年份:2010
- 资助金额:
$ 149.18万 - 项目类别:
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