SWIFT DETECTION OF SPIO LABELED STEM CELLS GRAFTED IN THE MYOCARDIUM

快速检测移植到心肌中的 SPIO 标记干细胞

• 批准号: 8170460
• 负责人: MICHAEL GARWOOD
• 金额: $ 2.57万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170460
• 关键词: Anatomy; Cells; Computer Retrieval of Information on Scientific Projects Database; Detection; Dose; Funding; Grant; Heart; Image; Institution; Label; Methods; Myocardium; Research; Research Personnel; Resources; Source; Stem cells; United States National Institutes of Health; base; heart imaging; iron oxide; particle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of this project is to develop method based on SWIFT for detection of superparamagnetic iron oxide (SPIO) particle-labeled stem cells in biologically relevant doses in the heart. The preliminary ex- vivo imaging of the heart reveals that SWIFT imaginary images present the off-resonant spins as an enhanced (positive) boundary surrounding the region of SPIO-labeled cells while the on-resonant spins are not visible. SWIFT magnitude images provide myocardium anatomies thus eliminating the need for a separate reference image. Such feature of SWIFT facilitates the detection of stem cells compared to the GRE method.

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