National Biomedical Information Services

国家生物医学信息服务

• 批准号: 10261250
• 负责人: Jerry Sheehan
• 金额: $ 34021.45万
• 依托单位: NATIONAL LIBRARY OF MEDICINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10261250
• 关键词: 2019-nCoV; Adult; African American; All of Us Research Program; American Indians; Antimicrobial Resistance; Archives; Area; Bioinformatics; Biomedical Research; Biotechnology; Breast Feeding; COVID-19; COVID-19 pandemic; Centers for Disease Control and Prevention (U.S.); Chemicals; Child; ClinVar; Clinical; Clinical Data; Clinical Practice Guideline; Clinical Research; Clinical Trials; Collection; Common Core; Common Data Element; Communication; Communities; Computational Biology; Coronavirus; DNA Sequence; Data; Data Science; Data Set; Databases; Detection; Development; Diagnostic; Diagnostics Research; Disease Outbreaks; Drug Labeling; Emergency response; Environmental Health; Epidemiologic Monitoring; Epidemiology; Escherichia coli; Evaluation; Family; Genbank; General Population; Genes; Genetic; Genetic Databases; Genetic Variation; Genome; Genomics; Goals; Government; Guidelines; Hand; Health; Health Professional; Health Sciences; Health Services Needs; Health Services Research; Health Technology; Healthcare; Herbal supplement; Hispanics; History of Medicine; Hour; Human; Human Genome; Imagery; Information Centers; Information Dissemination; Information Services; Information Systems; Infrastructure; International; Intramural Research Program; Intuition; Investigational Drugs; Knowledge; Language; Latino; Lesbian Gay Bisexual Transgender Queer; Librarians; Libraries; Link; Listeria; Literature; Logical Observation Identifiers Names and Codes; Machine Learning; MeSH Thesaurus; Medical; Medical Informatics; Medically Underserved Area; MedlinePlus; Mentors; Methods; Modeling; Modernization; Molecular Biology; Mothers; Names; Nursing infant; Package Insert; Participant; Pathogen detection; Patients; Peer Review; Pharmaceutical Preparations; Phenotype; Play; Policies; Policy Maker; Politics; Population Group; Positioning Attribute; Preventive; Private Sector; Procedures; Process; Protein Structure Databases; Proteins; PubChem; PubMed; Public Health; Public Health Informatics; Public Sector; Publishing; Readability; Recipe; Records; Registries; Reporting; Research; Research Personnel; Resources; Retrieval; Role; SNOMED Clinical Terms; Salmonella; Sampling; Science; Scientist; Secure; Software Tools; Source; Speed; Strategic Planning; Support System; Surveys; System; Technology; Teenagers; Terminology; Testing; Text; Time; Toxicology Data Network; Training; Training Programs; Transcript; Translating; Travel; Trust; Underrepresented Populations; United States National Institutes of Health; United States National Library of Medicine; Universities; Update; Validation; Variant; Work; Workforce Development; Yellow Fever; bioinformatics tool; biomedical information system; citizen science; clinical diagnostics; cloud based; data archive; data management; data standards; data submission; data tools; database of Genotypes and Phenotypes; design; dietary supplements; digital; diverse data; environmental toxicology; ethnic minority population; exhibitions; foodborne illness; foodborne pathogen; genome database; genomic data; health data; health disparity; health information technology; health literacy; health training; implantable device; improved; industry partner; interoperability; journal article; language processing; literacy; liver injury; minority communities; outreach; pandemic disease; pathogen; petabyte; precision medicine; preservation; programs; public health emergency; research and development; research study; research to practice; response; rural underserved; scientific computing; skills; social health determinants; tool; urban underserved; virtual

In FY20, NLM significantly enhanced and expanded its National Biomedical Information Services. Added 1.2 million citations to PubMed (now with 31 million+ citations to biomedical journal articles), and launched a new PubMed platform with mobile friendly design and AI-powered intuitive search. Added 560,000 articles to PubMed Central (PMC), which now provides free public access to 6.3 million full text journal articles. Launched a pilot program to make full-text preprints available and searchable via PMC and PubMed, concentrating first on SARS-CoV-2 and COVID-19 related preprints. Partnered with White House Office of Science and Technology Policy and publishers to make a growing collection of more than 75,000 published coronavirus articles freely available in machine readable formats via the PMC Public Health Emergency Collection to support machine learning research. Launched, with university and industry partners, the COVID-19 Open Research Dataset (CORD-19), which provides openly available, full-text, machine readable pre-print and peer-reviewed coronavirus articles for machine analysis. Created LitCOVID, a curated literature hub for scientific information on 35,000+ SARS-CoV-2 articles in PubMed. Added 35,000+ new clinical research studies and 6,500 new results summaries to ClinicalTrials.gov (now 356,000 studies and 45,000 results summaries), including 4,000 clinical studies related to COVID-19, 2,800 of which are listed by WHO. Implemented new procedures to post results information within 30 days of submission and solicited public input to inform ongoing modernization effort. Provided reference information on environmental health and toxicology via TOXNET, including links to training materials and resources in NLMs PubChem and Bookshelf. Added to PubChem information on chemical compounds used in SARS-CoV-2 clinical trials and found in COVID-19-related Protein Database structures. Provided trusted consumer health information via MedlinePlus (medical tests, drugs and supplements, healthy recipes, and videos, 700+ resource links in 60 languages); added content on effects of genetic variation on human health. Developed evaluation plan to assess community needs for health services research information; continued to provide health services research information for researchers, practitioners, and policy makers. Provided drug information via NLMs Drug Information Portal, DailyMed (drug labeling information from package inserts for 126,000 drugs), LiverTox (clinical, diagnostic and research information and case registry on liver injury due to drugs, herbals and dietary supplements), LactMed (effects of 1,500 drugs, dietary supplements, and diagnostic agents on breastfeeding mothers and their nursing infants); and ChemID (1,900 new chemical items added with 400+ drugs related to COVID-19). Added 420 million genetic sequences to GenBank (which contains all publicly available DNA sequences), 40 million records (a 19% increase) to RefSeq (database of reference sequences including genomic, transcript, and protein) and 100,000 human genome sequence variants to ClinVar (archive of reports of the relationships among human variations and phenotypes). Launched a new search page for betacoronavirus gene sequences, including the latest outbreak data. Completed the transition of 36.4 petabytes of public and controlled-access genetic sequence data in Sequence Read Archive (SRA) to secure commercial clouds under the NIH STRIDES initiative to accelerate genomics research. Participated in SARS-CoV-2 Sequencing for Public Health Emergency Response, Epidemiology and Surveillance (SPHERES) consortium to coordinate U.S. efforts to provide publicly accessible SARS-CoV-2 sequence data in GenBank and SRA. Streamlined data submission and integrated data validation to support epidemiology (12,000 total SARS-CoV-2 sequences including 10,000+ complete genomes in GenBank; and 27,000+ SARS-CoV-2 sequence read datasets submitted to SRA). Established COVID-19 Genome Sequence Dataset, providing scientists free cloud-based access to SARS-CoV-2 SRA data via the NIH STRIDES Initiative. Processed genome sequence data for 197,000 samples via the Pathogen Detection pipeline to identify sources of human illnesses such as Salmonella, E. coli, and Listeria. Provided real-time US foodborne pathogen surveillance system used by FDA to support 660+ actions intended to protect consumers from foodborne illness. Provided access to antimicrobial resistance data for 590,000+ pathogens via AMRFinderPlus. Coordinated clinical data standards for HHS, provided tools for exchanging, analyzing, and facilitating interoperability of machine-readable clinical health data, and expedited content to help COVID-19 response: added 316,000 implantable devices to AccessGUDID database to support certified EHR interoperability requirements. Released SNOMED CT US Edition (3,800 new concepts, 40 relating to COVID-19), including concepts for capturing COVID-19 testing data, as requested by the CDC; released SNOMED CT International Edition interim version with WHO official naming for COVID-19 concepts. Supported continued expansion of LOINC (1,200 new terms for lab tests and observations, including 160 COVID-19-related); updated RxNorm (drug terminology resource) to include select investigational drugs related to pandemic and edited 10,000+ hand sanitizer entries supplied by the FDA; and enabled access to 660 COVID-19 related value sets. Added seven new Supplementary Concept Records related to Medical Subject Headings (MeSH) for SARS-CoV-2 and COVID-19 treatment and detection. Contributed to trans-NIH work to make COVID-19 specific survey items publicly available and identify core common data elements related to COVID-19 and social determinants of health. Via the Network of the National Library of Medicine (8,200+ libraries, information centers, and other organizations): increased engagement nationwide to promote diversity, equity, and inclusion, e.g., by educating people in communities traditionally underrepresented in biomedical research about precision medicine, digital literacy, and the NIH All of Us Research Program. Projects and programs covering health disparities priority areas included: health literacy; rural, urban and medically underserved areas; and population groups including ethnic and minority communities, LGBTQ, children, teens, adults, and seniors. Trained public library staff to use high-quality health information; trained health sciences librarians in research data management and data science; and encouraged citizen science. Conducted 4,000 activities reaching 1.5 million participants (398 organizations led projects; citizen science activities resulted in 160 new citations to 77 preventive health and wellness articles on Wikipedia that received almost 2 million views). Combined contemporary and historical inquiry to advance biomedical knowledge via: 37 NLM traveling exhibitions (265,000 visitors); online exhibitions (590,000 visitors), including two new exhibitions linking to 5,200 pages of digitized collection materials; three host venues virtually hosting The Politics of Yellow Fever exhibition; and selecting six Michael E. DeBakey Fellows in the History of Medicine who will conduct research using NLM historical collections when conditions allow them onsite. Expanded Data Science NLM Training program: mentoring program with capstone project and practical skills classes; trained 26 staff in 60-hour intensive Data Science Fundamentals course. Has become a model for data science workforce development across government.

在2020财年，NLM显著加强和扩大了其国家生物医学信息服务。