Biomechanics of accommodation

住宿生物力学

• 批准号: 10260390
• 负责人: Kirill V Larin
• 金额: $ 58.2万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10260390
• 关键词: Age; Anatomy; Animals; Biomechanics; Biometry; Clinic; Clinical; Coupling; Crystalline Lens; Custom; Data; Development; Devices; Elasticity; Eye; Goals; Human; Imaging Device; Investigation; Knowledge; Lens development; Measurable; Measurement; Measures; Mechanics; Methods; Microscopy; Modality; Monitor; Optical Coherence Tomography; Optical Instrument; Optics; Oryctolagus cuniculus; Outcome; Physiology; Preclinical Testing; Presbyopia; Procedures; Quality of life; Research Design; Retreatment; Role; Stress; Stretching; Surface; System; Techniques; Technology; Testing; Therapeutic procedure; Time; Tissues; Treatment outcome; Validation; Vision; age related; biomechanical model; design; elastography; functional outcomes; human subject; image guided; in vivo; instrument; instrumentation; lens; mechanical properties; multidisciplinary; multimodality; new technology; novel; preservation; research clinical testing; treatment effect; treatment optimization

PROJECT ABSTRACT Presbyopia, the progressive age-related loss of near visual function, is associated with a stiffening of the crystalline lens. There are currently several investigational approaches for presbyopia treatment that rely on lens softening or lens replacement with softer materials. Lens softening approaches are expected to have a transformative impact on the field because they are non-invasive and they preserve the anatomical relationship between the lens and other tissues involved in accommodation. They have therefore the potential to restore the natural dynamic accommodative function. However, one of the fundamental roadblocks towards the development of lens softening procedures is that there is currently no method available to directly measure lens stiffness and thus assess the efficacy of lens softening procedures in vivo. The goal of the project is to develop new technology capable of precise spatially-resolved non-destructive, noninvasive and depth-resolved quantitative measurements of the lens mechanical properties in a clinical setting. The technology will combine Brillouin microscopy, Optical Coherence Tomography (OCT), and Optical Coherence Elastography (OCE) - BOE. The instrument will be used to generate the first age-dependent data on lens mechanical properties quantified in vivo as well as quantitatively assess therapeutic procedures aimed to restore accommodation. Our overall hypothesis is that the novel BOE technology can acquire absolute measurements of the lens stiffness gradient with the accuracy and precision required to detect both age-related changes and changes induced by lens softening treatments. The ability to quantify lens softening in vivo will have a major impact on pre-clinical and clinical testing, validation and optimization of lens softening procedures. The project has three specific aims: Aim 1: Develop a combined BOE imaging device for depth-resolved quantitative lens elastography. Aim 2: Validate BOE measurements in animal and human lens ex vivo and animal lens in vivo. Aim 3: Quantify the mechanical properties of the human lens in vivo To accomplish our objective, we have assembled a multidisciplinary team with expertise in optical coherence tomography and elastography (Larin), Brillouin technology (Scarcelli), biomechanical modeling (Aglyamov), clinical ophthalmic instrumentation and crystalline lens physiology (Manns, Parel, Ruggeri, Yoo).

项目摘要 老花眼是一种与年龄相关的近视功能的逐渐丧失， 晶体透镜。目前有几种依赖于透镜的老视治疗的研究方法 软化或用较软的材料替换透镜。预计透镜软化方法具有 对该领域的变革性影响，因为它们是非侵入性的，并且它们保留了解剖关系 在透镜和其他参与调节的组织之间。因此，他们有可能恢复 自然动态补偿功能。然而，实现这一目标的一个根本障碍是， 透镜软化过程的一个发展是目前没有可用于直接测量透镜的方法 硬度，从而评估体内透镜软化过程的功效。 该项目的目标是开发新技术，能够精确的空间分辨无损， 在临床上对透镜机械特性进行无创和深度分辨的定量测量 设置.该技术将结合联合收割机布里渊显微镜，光学相干断层扫描（OCT），光学 相干弹性成像（OCE）- BOE。该仪器将用于生成第一个年龄相关数据， 体内量化的透镜机械性能以及定量评估旨在 恢复住宿。 我们的总体假设是，新型BOE技术可以获得透镜刚度的绝对测量值 梯度的准确度和精密度，以检测与年龄有关的变化和 透镜软化处理。量化体内透镜软化的能力将对临床前研究产生重大影响。 以及透镜软化程序的临床测试、验证和优化。 该项目有三个具体目标： 目标1：开发用于深度分辨定量透镜弹性成像的组合BOE成像设备。 目的2：动物和人离体透镜以及动物体内透镜中的EBOE测量。 目标3：量化体内人体透镜的机械性能 为了实现我们的目标，我们组建了一个具有光学相干专业知识的多学科团队 断层扫描和弹性成像（Larin），布里渊技术（Scarcelli），生物力学建模（Aglyamov）， 临床眼科仪器和晶体透镜生理学（Manns，Parel，Ruggeri，Yoo）。