Biomechanics of accommodation

住宿生物力学

• 批准号: 10260390
• 负责人: Kirill V Larin
• 金额: $ 58.2万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10260390
• 关键词: Age; Anatomy; Animals; Biomechanics; Biometry; Clinic; Clinical; Coupling; Crystalline Lens; Custom; Data; Development; Devices; Elasticity; Eye; Goals; Human; Imaging Device; Investigation; Knowledge; Lens development; Measurable; Measurement; Measures; Mechanics; Methods; Microscopy; Modality; Monitor; Optical Coherence Tomography; Optical Instrument; Optics; Oryctolagus cuniculus; Outcome; Physiology; Preclinical Testing; Presbyopia; Procedures; Quality of life; Research Design; Retreatment; Role; Stress; Stretching; Surface; System; Techniques; Technology; Testing; Therapeutic procedure; Time; Tissues; Treatment outcome; Validation; Vision; age related; biomechanical model; design; elastography; functional outcomes; human subject; image guided; in vivo; instrument; instrumentation; lens; mechanical properties; multidisciplinary; multimodality; new technology; novel; preservation; research clinical testing; treatment effect; treatment optimization

PROJECT ABSTRACT Presbyopia, the progressive age-related loss of near visual function, is associated with a stiffening of the crystalline lens. There are currently several investigational approaches for presbyopia treatment that rely on lens softening or lens replacement with softer materials. Lens softening approaches are expected to have a transformative impact on the field because they are non-invasive and they preserve the anatomical relationship between the lens and other tissues involved in accommodation. They have therefore the potential to restore the natural dynamic accommodative function. However, one of the fundamental roadblocks towards the development of lens softening procedures is that there is currently no method available to directly measure lens stiffness and thus assess the efficacy of lens softening procedures in vivo. The goal of the project is to develop new technology capable of precise spatially-resolved non-destructive, noninvasive and depth-resolved quantitative measurements of the lens mechanical properties in a clinical setting. The technology will combine Brillouin microscopy, Optical Coherence Tomography (OCT), and Optical Coherence Elastography (OCE) - BOE. The instrument will be used to generate the first age-dependent data on lens mechanical properties quantified in vivo as well as quantitatively assess therapeutic procedures aimed to restore accommodation. Our overall hypothesis is that the novel BOE technology can acquire absolute measurements of the lens stiffness gradient with the accuracy and precision required to detect both age-related changes and changes induced by lens softening treatments. The ability to quantify lens softening in vivo will have a major impact on pre-clinical and clinical testing, validation and optimization of lens softening procedures. The project has three specific aims: Aim 1: Develop a combined BOE imaging device for depth-resolved quantitative lens elastography. Aim 2: Validate BOE measurements in animal and human lens ex vivo and animal lens in vivo. Aim 3: Quantify the mechanical properties of the human lens in vivo To accomplish our objective, we have assembled a multidisciplinary team with expertise in optical coherence tomography and elastography (Larin), Brillouin technology (Scarcelli), biomechanical modeling (Aglyamov), clinical ophthalmic instrumentation and crystalline lens physiology (Manns, Parel, Ruggeri, Yoo).

项目摘要 老花眼是一种与年龄相关的进行性近视功能丧失，与眼球僵硬有关。 水晶透镜。目前有几种依靠镜片治疗老花眼的研究方法 软化或用更柔软的材料更换镜片。镜片软化方法预计将有一个 对这一领域产生变革性影响，因为它们是非侵入性的，并保留了解剖关系 在晶状体和其他参与调节的组织之间。因此，他们有可能恢复 自然的动态调节功能。然而，实现这一目标的根本障碍之一是 透镜软化程序的发展是目前还没有直接测量透镜的方法 并因此评估体内晶状体软化手术的效果。 该项目的目标是开发能够精确空间分辨的无损检测的新技术， 临床晶状体机械特性的无创和深度分辨定量测量 布景。这项技术将结合布里渊显微镜、光学相干层析成像(OCT)和光学 相干弹性成像(OCE)-BOE。该仪器将用于生成第一个与年龄相关的数据 在活体内量化晶状体的机械性能以及定量评估旨在 恢复住宿。 我们的总体假设是，新的BOE技术可以获得镜片硬度的绝对测量 梯度，具有检测与年龄相关的变化和由 晶状体软化处理。在体内量化晶状体软化的能力将对临床前产生重大影响 以及临床测试、验证和优化晶状体软化程序。 该项目有三个具体目标： 目的1：研制一种用于深度分辨定量晶状体弹性成像的组合式BOE成像装置。 目的2：验证动物和人晶状体以及动物体内晶状体的BOE测量结果。 目的3：在活体内量化人类晶状体的机械特性 为了实现我们的目标，我们组建了一支拥有光学相干专业知识的多学科团队 断层扫描和弹性成像(Larin)、布里渊技术(Scarcelli)、生物力学建模(Agaramov)、 临床眼科仪器和晶状体生理学(曼斯、帕雷尔、鲁盖里、尤)。