No-Touch High Resolution Optical Coherence Elastography of the Cornea using a Heartbeat

使用心跳进行角膜非接触式高分辨率光学相干弹性成像

• 批准号: 10705274
• 负责人: Kirill V Larin
• 金额: $ 55.74万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705274
• 关键词: 3-Dimensional; Acceleration; Achievement; Adoption; Agreement; Air; Algorithms; Biomechanics; Cataract Extraction; Characteristics; Clinic; Clinical; Collagen; Connective Tissue; Cornea; Corneal Diseases; Detection; Development; Diagnostic; Diagnostic tests; Discipline; Disease; Elasticity; Eye; Eye Development; Eye diseases; Frequencies; Glaucoma; Goals; Health; Human; Iatrogenesis; Image; Intervention; Journals; Keratoconus; Keratoplasty; Knowledge; Laser In Situ Keratomileusis; Link; Local Therapy; Maps; Measurement; Measures; Mechanics; Methods; Modeling; Myopia; Nature; Office Visits; Operative Surgical Procedures; Optics; Oryctolagus cuniculus; Paper; Pathologic; Patients; Performance; Pharmacotherapy; Phase; Physiologic Intraocular Pressure; Physiologic pulse; Physiological; Procedures; Property; Protocols documentation; Reporting; Resolution; Retina; Routine Diagnostic Tests; Scanning; Sclera; Source; Speed; System; Techniques; Technology; Testing; Therapeutic; Therapeutic Intervention; Therapeutic procedure; Tissue Transplantation; Tissues; Touch sensation; Translations; Visual System; biomechanical test; clinic ready; clinical practice; clinical translation; corneal epithelial wound healing; corneal surgery; crosslink; design; disease diagnosis; efficacy testing; elastography; improved; improved outcome; in vivo; innovative technologies; mechanical properties; new technology; next generation; novel; novel strategies; personalized medicine; research clinical testing; response; screening; spatiotemporal; submicron; success; translational applications; translational potential; wound healing

PROJECT SUMMARY The mechanical properties of the cornea determine the structural characteristics of the ocular globe and may be altered in several devastating disease states, including axial elongation in myopia, pathological deformation in keratoconus, and iatrogenic keratoectasia following corneal refractive surgery. Accurate measurement of corneal biomechanics with high spatial resolution would not only influence our clinical interpretation of diagnostic tests, e.g., measuring intraocular pressure or assessing effects of drug therapies, but also predict the development of posterior eye diseases, such as glaucoma. Currently, there is no available reliable method to perform quantitative measurement of corneal elasticity in vivo and with high resolution. Here we propose a novel method for a “no- touch” assessment of corneal elastic properties. Such a technology, termed heart-beat optical coherence elastography (hbOCE), could revolutionize methods for routine corneal examination, bringing additional mechanical information and warrant rapid clinical adaptation. The project has four primary Specific Aims: Aim 1 is focused on the development of a hbOCE system capable of high-speed volumetric measurement of corneal deformation under small intrinsic IOP changes. Aim 2 will test the developed system in the eyes ex vivo. Aim 3 will test the system in eyes in vivo in rabbits. Aim 4 will perform in vivo human studies to refine measurement methods for broader clinical use. The proposed project will make fundamental advances in the understanding of corneal biomechanics through a novel approach with potentially impactful applications in other disciplines (e.g., corneal surgery, LASIK, corneal cross-linking, corneal transplants, personalized treatments). Most importantly, the proposed studies will accelerate the transition of ocular elastography into clinics, influence our selection and application of corneal surgical treatments, and will help us understand the structural consequences of corneal diseases and wound healing.

项目概要 角膜的机械特性决定了眼球的结构特征，并且可能是 在几种破坏性疾病状态下发生改变，包括近视眼轴伸长、近视病理性变形 圆锥角膜和角膜屈光手术后医源性角膜扩张。准确测量角膜 具有高空间分辨率的生物力学不仅会影响我们对诊断测试的临床解释， 例如，测量眼压或评估药物治疗的效果，还可以预测疾病的发展 眼后部疾病，例如青光眼。目前还没有可靠的方法可以进行定量分析 高分辨率的活体角膜弹性测量。在这里，我们提出了一种“不 角膜弹性特性的“触摸”评估。这种技术称为心跳光学相干性 弹性成像（hbOCE）可以彻底改变常规角膜检查的方法，带来更多 机械信息并保证快速临床适应。 该项目有四个主要具体目标： 目标 1 专注于开发能够高速体积测量的 hbOCE 系统 内在眼压变化较小时角膜变形。 Aim 2 将在离体眼睛中测试开发的系统。 Aim 3 将在兔子体内的眼睛中测试该系统。 Aim 4 将进行人体体内研究，以完善测量方法，以供更广泛的临床使用。 拟议的项目将通过以下方法在对角膜生物力学的理解方面取得根本性进展： 在其他学科（例如角膜手术、LASIK、角膜 交联、角膜移植、个性化治疗）。最重要的是，拟议的研究将 加速眼部弹性成像向临床的转化，影响我们角膜的选择和应用 手术治疗，并将帮助我们了解角膜疾病和伤口的结构后果 康复。