Prenatal Exposure to Environmental Tobacco Smoke, COVID-19- Related Psychosocial Stress, and Neurodevelopment.

产前暴露于环境烟草烟雾、与 COVID-19 相关的社会心理压力和神经发育。

• 批准号: 10282859
• 负责人: AMY MARGOLIS
• 金额: $ 11万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-24 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10282859
• 关键词: Address; Affect; Age Distribution; Air Pollution; Attention; Award; Behavioral; Birth; Brain; COVID-19; COVID-19 pandemic; Chemical Exposure; Chemicals; Child; Child Development; Child Health; Childhood; DSM-V; Data; Data Analyses; Development; Enrollment; Environmental Exposure; Environmental Risk Factor; Etiology; Exposure to; Family; Food; Functional Magnetic Resonance Imaging; Funding; Future; Genetic; Health; Home environment; Human; Individual; Infection; Inferior frontal gyrus; K-Series Research Career Programs; Latinx; Learning; Life; Literature; Low income; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Mental Health; Minority Groups; Natural experiment; Nature; Neighborhoods; Neurobiology; New York City; Observational Study; Occupations; Outcome; Parents; Participant; Pediatrics; Policies; Principal Investigator; Process; Psychosocial Stress; Public Health; Quarantine; Questionnaires; Research; Research Personnel; Research Training; Risk; Role; Schools; Scoring Method; Shelter facility; Siblings; Stress; Structure; Surveys; Testing; Thalamic structure; Training Programs; United States National Institutes of Health; acute stress; acute traumatic stress disorder; age related; behavior change; brain behavior; cognitive control; cohort; design; environmental tobacco smoke; environmental tobacco smoke exposure; experience; interest; longitudinal analysis; neurobehavior; neurodevelopment; neuroimaging; neurotoxic; pandemic disease; prenatal; prenatal exposure; psychosocial stressors; skills; social; stress symptom; stressor; symptomatology; working group

Prenatal chemical and childhood social exposures have compounding effects on children’s attention problems. To date, research on the etiology of attention problems has focused largely on endogenous, internal factors such as genetics, with little attention paid to the contribution of exogenous, environmental factors, such as neurotoxic exposures. In the parent award we detected significant associations between prenatal ETS exposure and the structure and function of children’s frontostriatal circuitry. Further, associations between prenatal ETS exposure and attention problems were mediated by changes in frontostriatal structure. These findings derive from the research and training program proposed in a Career Development Award that has supported the applicant towards becoming an NIH-funded independent investigator. This supplement funding will allow the Principal Investigator to study if COVID-19-related psychosocial stressors or acute stress symptoms magnify the effects of prenatal exposure to environmental tobacco smoke (ETS) on children’s brain function and attention. The data acquired with this supplemental funding will test the hypothesis that higher levels of COVID-19 pandemic-related psychosocial stressors or acute stress symptoms will amplify previously detected effects of prenatal ETS exposure on the structure and function of frontostriatal circuitry and attention problems that are subserved by this circuit. Through this Career Development Award, Dr. Margolis has developed expertise in using neuroimaging to study of the effects of neurotoxic environmental exposures on brain development and the manifestation of learning and attention problems. The current supplement to the parent award will allow Dr. Margolis to further develop her skills through acquiring and analyzing longitudinal functional magnetic resonance imaging (fMRI) data. In addition, this funding will support her in analyzing data from the new Environmental influences on Children’s Health Outcomes (ECHO) COVID-19 Acute Stress Questionnaire, which she co-authored. She will disseminate these methods for scoring and interpreting the Acute Stress questions in her role as Co-chair of the ECHO neurodevelopment working group. RELEVANCE: The current research will allow us to determine if pandemic-related psychosocial stressors and acute stress symptoms increase the behavioral and neurobiological effects of ETS. Such information may allow practitioners to treat attention problems through addressing acute stress symptoms and other pandemic- related psychosocial stressors (school and family factors). This approach may also generate data for public health messaging to mental health and pediatrics practitioners to consider the broad effects of increased stress and stressors on a range of other mental health problems during future pandemics.

产前化学物质和儿童时期的社会接触会对儿童的注意力问题产生复合影响。 迄今为止，对注意力问题病因学的研究主要集中在内源性、内部因素上。 例如遗传因素，很少关注外源环境因素的贡献，例如 神经毒性暴露。在家长奖中，我们发现产前 ETS 之间存在显着关联 暴露以及儿童额纹状体电路的结构和功能。此外，之间的关联 产前 ETS 暴露和注意力问题是由额纹状体结构的变化介导的。这些 研究结果来自于职业发展奖中提出的研究和培训计划， 支持申请人成为 NIH 资助的独立调查员。本次补充资金 将允许首席研究员研究是否存在与 COVID-19 相关的社会心理压力源或急性压力 症状放大了产前暴露于环境烟草烟雾（ETS）对儿童大脑的影响 功能和注意力。通过这笔补充资金获得的数据将检验以下假设： 之前与 COVID-19 大流行相关的心理社会压力源或急性应激症状的水平将会加剧 检测到产前 ETS 暴露对额纹状体回路结构和功能以及注意力的影响 该电路存在的问题。通过这个职业发展奖，马戈利斯博士 开发了使用神经影像学来研究神经毒性环境暴露对人的影响的专业知识 大脑发育以及学习和注意力问题的表现。目前的补充 家长奖将使马戈利斯博士能够通过获取和分析纵向数据进一步发展她的技能 功能磁共振成像（fMRI）数据。此外，这笔资金将支持她分析数据 来自新的环境对儿童健康结果的影响 (ECHO) COVID-19 急性应激 她与人合着的调查问卷。她将传播这些评分和解释方法 急性压力对她作为 ECHO 神经发育工作组联合主席的角色提出了质疑。 相关性：当前的研究将使我们能够确定与大流行相关的社会心理压力源和 急性应激症状会增加 ETS 的行为和神经生物学影响。此类信息可能 允许从业者通过解决急性应激症状和其他流行病来治疗注意力问题 相关的社会心理压力源（学校和家庭因素）。这种方法还可以为公众生成数据 向心理健康和儿科医生传达健康信息，以考虑压力增加的广泛影响 以及未来大流行期间一系列其他心理健康问题的压力源。

项目成果

Family nurture intervention for preterm infants facilitates positive mother-infant face-to-face engagement at 4 months.

• DOI: 10.1037/dev0000557
• 发表时间: 2018-11
• 期刊: Developmental psychology
• 影响因子: 4
• 作者: Beebe B;Myers MM;Lee SH;Lange A;Ewing J;Rubinchik N;Andrews H;Austin J;Hane A;Margolis AE;Hofer M;Ludwig RJ;Welch MG
• 通讯作者: Welch MG

Convergent neural correlates of prenatal exposure to air pollution and behavioral phenotypes of risk for internalizing and externalizing problems: Potential biological and cognitive pathways.

• DOI: 10.1016/j.neubiorev.2022.104645
• 发表时间: 2022-06
• 期刊: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
• 影响因子: 8.2
• 作者: Margolis, Amy E.;Liu, Ran;Conceicao, Vasco A.;Ramphal, Bruce;Pagliaccio, David;DeSerisy, Mariah L.;Koe, Emily;Selmanovic, Ena;Raudales, Amarelis;Emanet, Nur;Quinn, Aurabelle E.;Beebe, Beatrice;Pearson, Brandon L.;Herbstman, Julie B.;Rauh, Virginia A.;Fifer, William P.;Fox, Nathan A.;Champagne, Frances A.
• 通讯作者: Champagne, Frances A.

Bilingualism May Be Protective Against Executive Function and Visual Processing Deficits Among Children With Attention Problems.

双语可能可以预防有注意力问题的儿童的执行功能和视觉处理缺陷。

• DOI: 10.1177/1087054719861745
• 发表时间: 2021
• 期刊: Journal of attention disorders
• 影响因子: 3
• 作者: Hardy,LindsayM;Tomb,Meghan;Cha,Yoochai;Banker,Sarah;Muñoz,Francisco;Paul,Alexis;Margolis,AmyE
• 通讯作者: Margolis,AmyE

Contributions of Cerebellar White Matter Microstructure to Social Difficulty in Nonverbal Learning Disability.

• DOI: 10.1007/s12311-021-01265-4
• 发表时间: 2021-12
• 期刊: Cerebellum (London, England)
• 作者: Ramphal B;Pagliaccio D;Thomas LV;He X;Margolis AE
• 通讯作者: Margolis AE

Phonological memory problems are magnified in children from language minority homes when predicting reading disability.

当预测阅读障碍时，来自语言少数群体家庭的儿童的语音记忆问题会被放大。

• DOI: 10.1017/s0305000919000576
• 发表时间: 2020
• 期刊: Journal of child language
• 影响因子: 2.2
• 作者: Hardy,LindsayM;Banker,Sarah;Tomb,Meghan;Cha,Yoochai;Zhang,Irene;Thomas,Lauren;Algermissen,Molly;Peverly,StephenT;Noble,KimberlyG;Margolis,AmyE
• 通讯作者: Margolis,AmyE