Unit on Neurons, Circuits and Behavior

神经元、电路和行为单元

• 批准号: 10266631
• 负责人: Arash Afraz
• 金额: $ 224.23万
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10266631
• 关键词: Animals; Appearance; Area; Behavior; Behavioral; Brain; Cells; Color; Communication; Data Collection; Electrophysiology (science); Event; Eye; Eye Movements; Face; Goals; Humpback Dolphins; Image; Inferior; Measures; Memory; Microinjections; Nature; Neurons; Pattern; Pharmaceutical Preparations; Pharmacology; Phase; Physiology; Postdoctoral Fellow; Primates; Process; Psychophysics; Publications; Published Comment; Stream; System; Temporal Lobe; Visual Perception; artificial neural network; behavioral study; electrical microstimulation; insight; machine vision; object recognition; optogenetics; relating to nervous system; visual processing; visual search

During the past year we have developed the lab to its mature state. We built three functional physiology setups (including eye trackers, electrophysiology and optogenetic closed-loop control systems). We also finished the hiring process and currently we have three postdocs actively leading separate projects. Our projects can be divided into two main classes. One, that includes about 75% of the lab activity involves incorporating machine vision and adversarial artificial neural networks for developing images that are indistinguishable from the state of neural perturbation. In a closed-loop system, the artificial neural network accumulates an internal record of the behavioral choices of the animal to artificially synthesize images that appear more similar to the animal to the altered perceptual state induced by the neural perturbation. We have launched 3 projects covering various aspects of this general approach. The other class of projects in the lab involves measuring the effect of pharmacological neural perturbation in the face-selective parts of the inferior temporal cortex on eye movements and the behavioral pattern of visual search. We are still in the data collection phase for these recently launched projects. We have had two publications in 2019, one is a commentary in Cell (Insight into the Neuron's Insight. Afraz A. Cell. 2019 May 2;177(4):801-803. doi: 10.1016/j.cell.2019.04.019.) and the other is a collaborative behavioral study that came out in Nature Communications (Paradoxical impact of memory on color appearance of faces. Hasantash M, Lafer-Sousa R, Afraz A, Conway BR. Nat Commun. 2019 Jul 8;10(1):3010. doi: 10.1038/s41467-019-10073-8.).

在过去的一年中，我们将实验室开发到其成熟状态。我们构建了三个功能性生理设置（包括眼镜，电生理学和光遗传学闭环控制系统）。我们还完成了招聘过程，目前，我们有三个专业领先的单独项目的博士后。 我们的项目可以分为两个主要类。其中之一包括大约75％的实验室活动涉及将机器视觉和对抗性人工神经网络纳入与神经扰动状态无法区分的图像。在闭环系统中，人工神经网络积累了动物的行为选择的内部记录，以人为地合成图像，这些图像看起来与动物更相似，与神经扰动引起的改变的感知状态。我们已经启动了3个项目，涵盖了这种一般方法的各个方面。实验室中的其他类别涉及测量下颞皮层的面部选择性部分对眼部运动的面部选择性部分的影响以及视觉搜索的行为模式。 这些最近启动的项目仍处于数据收集阶段。 我们在2019年有两份出版物，其中一本是细胞的评论（对神经元的见解。AfrazA.Cell。2019； 177（4）：801-803。doi：10.1016/j.cell.2019.04.019。 R，Afraz A，Nat Commun。