Unit on Neurons, Circuits and Behavior

神经元、电路和行为单元

• 批准号: 10929842
• 负责人: Arash Afraz
• 金额: $ 204.84万
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10929842
• 关键词: Area; Behavior; Behavioral; Brain; Chronic; Dependence; Event; Eye; Eye Movements; Face; Goals; Hallucinations; Humpback Dolphins; Image; Implantation procedure; Inferior; Journals; Link; Macaca; Machine Learning; Manuscripts; Measures; Microinjections; Nature; Neurons; Operative Surgical Procedures; Paper; Pharmaceutical Preparations; Primates; Printing; Psychophysics; Publishing; Stream; Surgical complication; Temporal Lobe; Viral; Visual; Visual Perception; electrical microstimulation; extrastriate visual cortex; implantation; inferotemporal cortex; neural; nonhuman primate; object recognition; optogenetics; visual processing; visual stimulus

During the past year we have submitted multiple manuscripts, most of them are already published, two are still waiting for their final journal acceptance (preprints published in bioRxiv). Following, is the list of published papers: 1. The study that establishes the complicated surgical procedures for viral transduction in inferior temporal cortex and chronic array implantation: Azadi R, Bohn S, Eldridge MAG, Afraz A. Surgical Procedure for Implantation of Opto-Array in Nonhuman Primates. Curr Protoc. 2023 Mar;3(3):e704. doi: 10.1002/cpz1.704. PMID: 36912623; PMCID: PMC10020889. 2. The study that establishes the visual nature of the effect of neural perturbation in inferior temporal cortex: Azadi R, Bohn S, Lopez E, Lafer-Sousa R, Wang K, Eldridge MAG, Afraz A. Image-dependence of the detectability of optogenetic stimulation in macaque inferotemporal cortex. Curr Biol. 2023 Feb 6;33(3):581-588.e4. doi: 10.1016/j.cub.2022.12.021. Epub 2023 Jan 6. PMID: 36610394; PMCID: PMC9905296. 3. The study that shows dependence of the perceptual events following brain stimulation (in inferior temporal cortex) on the visibility of visual stimuli presented to the eyes: Lafer-Sousa R, Wang K, Azadi R, Lopez E, Bohn S, Afraz A. Behavioral detectability of optogenetic stimulation of inferior temporal cortex varies with the size of concurrently viewed objects. Curr Res Neurobiol. 2022 Dec 6;4:100063. doi: 10.1016/j.crneur.2022.100063. PMID: 36578652; PMCID: PMC9791129. 4. The study that unveils the causal link between neural activity in face selective neurons and free viewing eye movements (preprint): Azadi R, Lopez E, Taubert J, Patterson A, Afraz A. Inactivation of face selective neurons alters eye movements when free viewing faces. bioRxiv Preprint. 2023 Jul 11:2023.06.20.544678. doi: 10.1101/2023.06.20.544678. PMID: 37502993; PMCID: PMC10370202. 5. Perceptography; photographing the perceptual effect of brain stimulation with a combination of high throughput optogenetic brain stimulation and machine learning (preprint): Elia Shahbazi, Timothy Ma, Martin Pernu, Walter Scheirer, Arash Afraz. Perceptography: unveiling visual perceptual hallucinations induced by optogenetic stimulation of the inferior temporal cortex. bioRxiv 2022.10.24.513337; doi: https://doi.org/10.1101/2022.10.24.513337 In summary, during the last year we made significant progress in establishing quantitative and causal links between neural activity in the inferior temporal cortex (high level visual area associated with object recognition) and different measures of visual perception.

在过去的一年中，我们提交了多个手稿，其中大多数已经出版，两个仍在等待他们的最终期刊接受（Biorxiv发表的预印本）。以下是已发表论文的列表：1。建立了颞颞皮层和慢性阵列植入病毒转导的复杂手术程序的研究：Azadi R，Bohn S，Eldridge Mag，AfrazA。 Curr Protoc。 2023年3月; 3（3）：E704。 doi：10.1002/cpz1.704。 PMID：36912623; PMCID：PMC10020889。 2。建立神经扰动在下颞皮质中影响的视觉性质的研究： Azadi R，Bohn S，Lopez E，Lafer-Sousa R，Wang K，Eldridge Mag，AfrazA。猕猴上颞皮层中光遗传刺激的可检测性的图像依赖性。 Curr Biol。 2023年2月6日； 33（3）：581-588.e4。 doi：10.1016/j.cub.2022.12.021。 EPUB 2023 JAN6。PMID：36610394; PMCID：PMC9905296。 3。表明大脑刺激后感知事件（在颞皮层下）对视觉刺激的可见性的依赖性的研究： Lafer-Sousa R，Wang K，Azadi R，Lopez E，Bohn S，AfrazA。下颞皮层的光遗传学刺激的行为可检测性随着同时查看的物体的大小而变化。 Curr Res Neurobiol。 2022年12月6日; 4：100063。 doi：10.1016/j.crneur.2022.100063。 PMID：36578652; PMCID：PMC9791129。 4。揭示了面部选择性神经元中神经活动与自由观察眼运动（预印本）之间的因果关系的研究（预印本）： Azadi R，Lopez E，Taubert J，Patterson A，AfrazA。脸部选择性神经元的失活在自由观看时会改变眼动。 Biorxiv预印本。 2023年7月11日：2023.06.20.544678。 doi：10.1101/2023.06.20.544678。 PMID：37502993; PMCID：PMC10370202。 5。感知学；通过高通量光遗传学脑刺激和机器学习（预印本）的结合来拍摄脑刺激的感知效应： Elia Shahbazi，Timothy MA，Martin Pernu，Walter Scheirer，Arash Afraz。感知学：揭示视觉感知幻觉，这是由于下颞皮层的光遗传学刺激引起的。 Biorxiv 2022.10.24.513337; doi：https：//doi.org/10.1101/2022.10.24.513337 总而言之，在过去的一年中，我们在建立下颞皮层（与对象识别相关的高级视觉区域）与视觉感知的不同度量之间建立定量和因果关系方面取得了重大进展。

项目成果

Reply to Lev-Ari: Operational definition of "color perception"; which task represents the concept better?

• DOI: 10.1073/pnas.2026301118
• 发表时间: 2021-03-09
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Afraz A;Hasantash M
• 通讯作者: Hasantash M

Behavioral detectability of optogenetic stimulation of inferior temporal cortex varies with the size of concurrently viewed objects.

下颞叶皮层光遗传学刺激的行为可检测性随同时观看物体的大小而变化。

• DOI: 10.1016/j.crneur.2022.100063
• 发表时间: 2023
• 期刊: Current research in neurobiology
• 作者: Lafer-Sousa, Rosa;Wang, Karen;Azadi, Reza;Lopez, Emily;Bohn, Simon;Afraz, Arash
• 通讯作者: Afraz, Arash

Insight into the Neuron's Insight.

洞察神经元的洞察力。

• DOI: 10.1016/j.cell.2019.06.027
• 发表时间: 2019
• 期刊: Cell
• 影响因子: 64.5
• 作者: Afraz,Arash