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Core C: Vulnerable Populations Core

核心 C：弱势群体核心

基本信息

批准号：
10090778
负责人：
Stephanie Hart Parade
金额：
$ 25.86万
依托单位：
MIRIAM HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-15 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10090778
关键词：
Address Adult Behavioral Biological Centers of Research Excellence Child Childhood Clinical Communities Competence Data Development Disadvantaged Discrimination Disease Documentation Economics Educational workshop Environment Ethics Exposure to Faculty Goals Health Hospitals Individual Infrastructure Local Government Longevity Maintenance Medical Mental Health Outcome Population Population Heterogeneity Poverty Recording of previous events Relationship-Building Research Research Personnel Research Project Grants Resources Risk Risk Factors Services Sexual and Gender Minorities Socioeconomic Status State Government Stress Structure Symptoms Training Trauma Underserved Population Vulnerable Populations Work biobehavior childhood adversity clinically significant community partnership disadvantaged background diversity and equity ethnic minority population experience human subject human subject protection innovation marginalized population physical conditioning racial minority recruit resilience social exclusion social stigma success

项目摘要

PROJECT SUMMARY / ABSTRACT The COBRE for Stress, Trauma, and Resilience (STAR) will establish a transformative, transdisciplinary Miriam Hospital research center focused on the biobehavioral mechanisms through which childhood stress, trauma, and adversity impact health outcomes across development. Childhood adversity is a major risk factor for physical and mental health problems across the lifespan, yet those with adverse exposures are highly likely to be underserved due to socioeconomic position. Children and adults from disadvantaged backgrounds, including racial and ethnic minorities, individuals living in poverty, and sexual minority and gender diverse populations are at substantially heightened risk of exposure to adversity. Further, although disadvantaged communities are most likely to experience adversity and trauma, they are often difficult to reach and engage in research as a result of societal discrimination, medical mistrust, marginalization, stigma, and economic and structural factors. Specialized infrastructure to address the practical, ethical, and clinical issues in research with vulnerable and underserved populations is critical for long-term success of the STAR COBRE. The Human Subjects and Vulnerable Populations (VP) Core will support the overall goals of the STAR COBRE by building critical infrastructure to support clinically significant and highly innovative research with vulnerable children and adults with stress and trauma histories. In addition, because all three proposed research projects in this COBRE include data and biospecimens from human subjects, the VP Core will serve as a recommended hub for documentation and training related to human subjects’ protection for all components of the COBRE (PAR-19-313). The VP Core will provide resources and support targeted to developing capacity to successfully recruit and retain difficult to reach populations, while maintaining to standards in the ethical conduct of research with children and adults with stress and trauma histories. The VP Core will also provide support to enhance existing and build new community partnerships, and to increase competence of COBRE faculty and staff regarding issues of diversity, equity, and inclusion. The VP Core will be essential to the overall success of the STAR COBRE by providing critical expertise, services, and infrastructure to support clinically significant and highly innovative research with vulnerable children and adults with stress and trauma histories.

项目摘要/摘要