Core C: Vulnerable Populations Core

项目摘要/摘要 压力、创伤和复原力眼镜蛇(STAR)将建立一个变革性的、跨学科的 Miriam医院研究中心专注于儿童压力、 创伤和逆境会影响整个发展阶段的健康结果。童年的逆境是一个主要的危险因素。 对于一生中的身体和精神健康问题，但那些有不良接触的人很有可能 由于社会经济地位而得不到充分的服务。来自贫困家庭的儿童和成年人， 包括种族和族裔少数群体、生活在贫困中的个人以及性别少数和性别多样化 人们暴露在逆境中的风险大大增加。此外，尽管处于不利地位， 社区最有可能经历逆境和创伤，他们往往很难接触到并参与其中 由于社会歧视、医疗不信任、边缘化、耻辱和经济和 结构性因素。专门的基础设施，以解决研究中的实际、伦理和临床问题 与弱势群体和服务不足的人群是明星眼镜蛇的长期成功的关键。这个 人类主体和弱势群体(VP)核心将支持STAR的总体目标 Cobre通过构建关键基础设施来支持具有临床意义和高度创新的 对有压力和创伤病史的弱势儿童和成年人进行研究。另外，因为所有的 本研究的三个拟议研究项目包括来自人类受试者的数据和生物谱，即VP CORE将作为与人类受试者相关的文件和培训的推荐中心 为Cobre的所有组件提供保护(PAR-19-313)。副总裁核心将提供资源和 支持旨在发展成功招募和留住难以接触到的人群的能力， 同时保持对有压力的儿童和成人进行研究的道德行为的标准 精神创伤病史。副总裁核心还将提供支持，以加强现有社区并建立新社区 合作伙伴关系，并提高科博尔教职员工在多样性、公平、 和包容性。副总裁核心对于STAR Cobre的整体成功至关重要，因为它提供了关键的 专业知识、服务和基础设施，支持具有临床意义和高度创新的研究 易受伤害的儿童和有压力和创伤病史的成年人。

PROJECT SUMMARY / ABSTRACT The COBRE for Stress, Trauma, and Resilience (STAR) will establish a transformative, transdisciplinary Miriam Hospital research center focused on the biobehavioral mechanisms through which childhood stress, trauma, and adversity impact health outcomes across development. Childhood adversity is a major risk factor for physical and mental health problems across the lifespan, yet those with adverse exposures are highly likely to be underserved due to socioeconomic position. Children and adults from disadvantaged backgrounds, including racial and ethnic minorities, individuals living in poverty, and sexual minority and gender diverse populations are at substantially heightened risk of exposure to adversity. Further, although disadvantaged communities are most likely to experience adversity and trauma, they are often difficult to reach and engage in research as a result of societal discrimination, medical mistrust, marginalization, stigma, and economic and structural factors. Specialized infrastructure to address the practical, ethical, and clinical issues in research with vulnerable and underserved populations is critical for long-term success of the STAR COBRE. The Human Subjects and Vulnerable Populations (VP) Core will support the overall goals of the STAR COBRE by building critical infrastructure to support clinically significant and highly innovative research with vulnerable children and adults with stress and trauma histories. In addition, because all three proposed research projects in this COBRE include data and biospecimens from human subjects, the VP Core will serve as a recommended hub for documentation and training related to human subjects’ protection for all components of the COBRE (PAR-19-313). The VP Core will provide resources and support targeted to developing capacity to successfully recruit and retain difficult to reach populations, while maintaining to standards in the ethical conduct of research with children and adults with stress and trauma histories. The VP Core will also provide support to enhance existing and build new community partnerships, and to increase competence of COBRE faculty and staff regarding issues of diversity, equity, and inclusion. The VP Core will be essential to the overall success of the STAR COBRE by providing critical expertise, services, and infrastructure to support clinically significant and highly innovative research with vulnerable children and adults with stress and trauma histories.