Core C: Vulnerable Populations Core

项目总结/摘要 压力、创伤和恢复力的COBRE（星星）将建立一个变革性的、跨学科的 米里亚姆医院的研究中心专注于儿童压力的生物行为机制， 创伤和逆境影响整个发展过程中的健康成果。童年时期的逆境是一个主要的风险因素 在整个生命周期中的身体和精神健康问题，但那些有不良暴露的人很有可能 由于社会经济地位而得不到充分的服务。来自弱势背景的儿童和成人， 包括种族和族裔少数群体、生活贫困的个人、性少数群体和性别多样性群体 民众面临逆境的风险大大增加。此外，尽管处于不利地位， 社区最有可能经历逆境和创伤，他们往往很难接触和参与 由于社会歧视、医疗不信任、边缘化、污名化以及经济和 结构性因素解决研究中的实践、伦理和临床问题的专业基础设施 对于星星COBRE的长期成功至关重要。的 人类受试者和弱势群体（VP）核心将支持星星的总体目标 COBRE通过构建关键基础设施来支持具有临床意义和高度创新的 对有压力和创伤史的弱势儿童和成年人的研究。此外，由于所有 该COBRE中的三个拟议研究项目包括来自人类受试者的数据和生物标本， 核心将作为与人类受试者相关的文档和培训的推荐中心， COBRE所有组件的保护（PAR-19-313）。副总裁核心将提供资源， 支助的目标是发展成功征聘和留住难以接触到的人口的能力， 同时保持对儿童和成年人进行研究的道德行为标准， 创伤史副总裁核心还将提供支持，以加强现有的和建立新的社区 伙伴关系，并提高COBRE教师和工作人员在多样性，公平， 和包容。副总裁核心将是至关重要的整体成功的星星眼镜蛇，提供关键 专业知识，服务和基础设施，以支持临床重要和高度创新的研究， 有压力和创伤史的弱势儿童和成人。

PROJECT SUMMARY / ABSTRACT The COBRE for Stress, Trauma, and Resilience (STAR) will establish a transformative, transdisciplinary Miriam Hospital research center focused on the biobehavioral mechanisms through which childhood stress, trauma, and adversity impact health outcomes across development. Childhood adversity is a major risk factor for physical and mental health problems across the lifespan, yet those with adverse exposures are highly likely to be underserved due to socioeconomic position. Children and adults from disadvantaged backgrounds, including racial and ethnic minorities, individuals living in poverty, and sexual minority and gender diverse populations are at substantially heightened risk of exposure to adversity. Further, although disadvantaged communities are most likely to experience adversity and trauma, they are often difficult to reach and engage in research as a result of societal discrimination, medical mistrust, marginalization, stigma, and economic and structural factors. Specialized infrastructure to address the practical, ethical, and clinical issues in research with vulnerable and underserved populations is critical for long-term success of the STAR COBRE. The Human Subjects and Vulnerable Populations (VP) Core will support the overall goals of the STAR COBRE by building critical infrastructure to support clinically significant and highly innovative research with vulnerable children and adults with stress and trauma histories. In addition, because all three proposed research projects in this COBRE include data and biospecimens from human subjects, the VP Core will serve as a recommended hub for documentation and training related to human subjects’ protection for all components of the COBRE (PAR-19-313). The VP Core will provide resources and support targeted to developing capacity to successfully recruit and retain difficult to reach populations, while maintaining to standards in the ethical conduct of research with children and adults with stress and trauma histories. The VP Core will also provide support to enhance existing and build new community partnerships, and to increase competence of COBRE faculty and staff regarding issues of diversity, equity, and inclusion. The VP Core will be essential to the overall success of the STAR COBRE by providing critical expertise, services, and infrastructure to support clinically significant and highly innovative research with vulnerable children and adults with stress and trauma histories.