Cognitive Training for Emotion Regulation in Psychotic Disorders

精神障碍情绪调节的认知训练

• 批准号: 10090645
• 负责人: GREGORY P STRAUSS
• 金额: $ 60.89万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10090645
• 关键词: Adherence; Adverse event; Affective; Amygdaloid structure; Attention; Benchmarking; Brain; Cellular Phone; Clinical; Clinical Treatment; Clinical Trials; Cognition; Cognitive remediation; Computer Models; Computers; Data; Delusions; Development; Diagnosis; Disease susceptibility; Distal; Ecological momentary assessment; Educational Intervention; Elements; Emotional; Emotions; Etiology; Goals; Hallucinations; Healthcare Systems; Individual; Intervention; Life; Maintenance; Mental disorders; Modality; Modeling; Modification; Neurocognition; Outcome; Outpatients; Participant; Patients; Pharmacology; Phase; Placebo Control; Placebos; Population; Prefrontal Cortex; Process; Protocols documentation; Psychoses; Psychotic Disorders; Randomized; Randomized Controlled Trials; Research; Resolution; Short-Term Memory; Signal Transduction; Specific qualifier value; Stress; Symptoms; Techniques; Testing; Therapeutic; Time; Training; Training Programs; Treatment Cost; Validation; Visual; active method; base; biological adaptation to stress; cognitive capacity; cognitive neuroscience; cognitive process; cognitive training; computerized; cost; design; effective therapy; effectiveness measure; emotion regulation; functional disability; functional outcomes; improved; improved outcome; indexing; mobile application; neuroimaging; neuromechanism; neuropsychiatric disorder; novel; novel strategies; optimal treatments; poor communities; precision medicine; primary outcome; programs; psychosocial; psychotic symptoms; relating to nervous system; response; secondary outcome; stress reactivity; therapy design; treatment trial

Project Summary Psychotic disorders are serious and debilitating mental illnesses that incur substantial suffering for patients and present major challenges to our health care system. Difficulties with emotion regulation (i.e., the ability to control the emotion response using strategies) significantly predict the development and maintenance of psychotic symptoms and poor community-based functional outcomes. Recent neuroimaging research indicates that hypofrontality may underlie these deficits. Unfortunately, there is no accepted technique for remediating these emotion regulation abnormalities in psychotic disorders. Recent advances from the field of cognitive neuroscience provide hope for a resolution to this critical unmet need in psychotic disorder therapeutics, demonstrating that brief computerized cognitive training interventions are capable of improving emotion regulation ability by targeting neural activation in the prefrontal cortex. The goal of the proposed project is to determine whether an emotional working memory (eWM) cognitive training program is effective for remediating emotion regulation abnormalities and associated clinical outcomes in people with psychotic disorders. In the R61 phase, outpatients with psychotic disorders will be randomly assigned to either an eWM (n = 20) or placebo (P: n = 20) cognitive training control intervention delivered via an app on a smartphone for 20 days. The primary aim of the R61 phase is to determine whether the eWM intervention successfully engages the target mechanism and enhances prefrontal activation on a non-trained emotion regulation transfer task beyond a pre-specified effect size criterion. Results of the R61 will also be used to determine the treatment modality (i.e., audio-only, visual-only, or combined audio-visual) and duration (10 vs. 20 days) that most effectively and efficiently improves the target. The goal of the R33 is to conduct an initial randomized controlled trial (RCT) of the optimal treatment identified in the R61. The R33 specific aims are to: 1) replicate and extend the R61 results supporting prefrontal target engagement in an adequately powered RCT (n = 80, 40 eWM, 40 P training); 2) determine if target engagement is associated with a proximal outcome of improved real-world emotion regulation ability (indexed via computational modeling of ecological momentary assessment data) and distal clinical outcomes of improved positive symptoms, negative symptoms, functional outcome, and neurocognition. If the R33 hypotheses are confirmed, results will inform the design of a later RCT for the early stages of psychosis, and to move toward a precision medicine approach that identifies which individuals are most likely to benefit from the intervention.

项目总结

项目成果

Social rejection sensitivity and its role in adolescent emotional disorder symptomatology.

• DOI: 10.1186/s13034-022-00555-x
• 发表时间: 2023-01-16
• 期刊: CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
• 影响因子: 5.6
• 作者: Minihan, Savannah;Kwok, Cassandra;Schweizer, Susanne
• 通讯作者: Schweizer, Susanne

Affective Control Training (AffeCT) reduces negative affect in depressed individuals.

• DOI: 10.1016/j.jad.2022.06.016
• 发表时间: 2022-07
• 期刊: Journal of affective disorders
• 影响因子: 6.6
• 作者: S. Schweizer;T. Auer;C. Hitchcock;L. Lee-Carbon;Evangeline Rodrigues;T. Dalgleish

Experimental Therapeutics: Opportunities and Challenges Stemming From the National Institute of Mental Health Workshop on Novel Target Discovery and Psychosocial Intervention Development.

实验治疗：来自国家心理健康研究所新目标发现和心理社会干预发展研讨会的机遇和挑战。

• DOI: 10.1177/17456916231197980
• 发表时间: 2023
• 期刊: Perspectives on psychological science : a journal of the Association for Psychological Science
• 作者: Zucker,NancyL;Strauss,GregoryP;Smyth,JoshuaM;Scherf,KSuzanne;Brotman,MelissaA;Boyd,RhondaC;Choi,Jimmy;Davila,Maria;Ajilore,OlusolaA;Gunning,Faith;Schweitzer,JulieB
• 通讯作者: Schweitzer,JulieB

The effectiveness of affective compared to neutral working memory training in university students with test anxiety.

• DOI: 10.1016/j.brat.2021.103974
• 发表时间: 2021-12
• 期刊: Behaviour research and therapy
• 影响因子: 4.1
• 作者: Minihan S;Samimi Z;Schweizer S
• 通讯作者: Schweizer S