Core A: Administrative and Research Translation Core (ARTC)
Core A: Administrative and Research Translation Core (ARTC)
批准号:
10559668
负责人:
BHAGAVATULA MOORTHY
金额:
$16.01万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-02-28 至 2025-01-31
关键词:
3-DimensionalAddressAdvisory CommitteesAreaAromatic Polycyclic HydrocarbonsBiological MarkersBirth RateBronchopulmonary DysplasiaBusinessesChildChronic lung diseaseClinicalCollaborationsCommittee MembersCommunicationCommunitiesCountryCountyCreativenessDataData AnalysesDetectionDevelopmentDisciplineEducationEnsureEnvironmental Engineering technologyEnvironmental HealthEpidemiologyExposure toFeedbackFosteringGoalsGovernmentGovernment AgenciesGrantHealthHealth ProfessionalInformation DisseminationInterdisciplinary CommunicationLeadershipLegal patentLifeMaternal ExposureMedicalMedical centerMedicineMorbidity - disease rateNational Institute of Environmental Health SciencesNeurocognitive DeficitNewsletterOccupational activity of managing financesOffice of Administrative ManagementOrganizational EfficiencyOutcomePatientsPersonsPlayPoisonPregnant WomenPremature BirthPremature InfantPreventionPublic HealthResearchResearch Project GrantsResearch SupportResourcesRiceRiskRisk AssessmentRisk FactorsRoleScienceSisterSiteSoilSuperfundSystemTechnology TransferTexasToddlerTrainingTraining ProgramsTranslational ResearchUnited States Environmental Protection AgencyUniversitiesUpdateWaterWorkcollegecommunity centercommunity engagementdata managementdata sharingdisease registryearly life exposureexperienceimprovedinvestigator-initiated translational researchmeetingsmemberorganizational structurepopulation basedprogramsremediationrisk minimizationscience teachersuccesssuperfund sitetranslational potentialweb sitewebinar
中文摘要
点击翻译按钮获取中文摘要
英文摘要
PROJECT SUMMARY
The preterm birth rate in Harris County, Houston, TX is an alarming 13.6% (national average in US is 9.6%), and
in areas surrounding Superfund sites, the preterm birth (PTB) rate is even higher (>20%). There are 15
Superfund sites in Harris County, posing a significant health risk to people living in the vicinity of these sites.
PTB often leads to many complications, including chronic lung disease, also termed bronchopulmonary dysplasia
(BPD), and some of these patients develop neurocognitive deficits later in life. One of the possible risk factors
for PTB are polycyclic aromatic hydrocarbons (PAHs), present in contaminated soil, sediments, and water at
various Superfund sites across the US, including in the greater Houston area. The over-arching hypothesis of
the BCM-Rice Superfund Research Program (SRP) is that maternal exposure to PAHs, which are present in
Superfund sites, increases the risk of PTB and incrementally augments major morbidities such as BPD and
neurocognitive deficits. The leaders of the Administrative and Research Translation Core (AC), Drs.
Bhagavatula Moorthy (Director), Pedro Alvarez (Deputy Director), Kjersti Aagaard, and Naomi Halas (Associate
Directors) will bring their collective scientific, educational, and leadership experience to guide the Baylor-Rice
SRP and address Superfund directives. The Administrative Core (AC) acts as the center of communication
within the Center, responsible for creating an efficient organizational structure. To this end, the Core will facilitate
interdisciplinary communication, collaboration, and integration of the Center’s Research Projects and cores.
Further, the Administrative Core will explore creative ways to promote investigator-initiated research translation
(IIRT) opportunities with assistance from the Research Translation Coordinators, Dr. Mellissa Bondy, and the
co-coordinator Dr. Philip Lupo. The AC will also play a key role in the communication with various external
stakeholders, including NIEHS and EPA, as well as with community partners, in close collaboration with the
Community Engagement Core (CEC). The AC will also take an active role with the Research Experience and
Training Coordination Core (RETCC) to create a vibrant training program and foster the development of
environmental health and science professionals. The Administrative Core will ensure financial responsibility and
management of the Center as well as work with the Data Management and Analysis Core (DMAC) to ensure
responsible management of data. This will include working with the Project and Core Leaders, Office of
Research, and Departments to ensure accomplishment of the proposed aims. The AC will also collaborate with
sister SRPs as needed and will leverage support and resources so the goals of the BCM-Rice SRP are
accomplished in a timely and efficient manner and avoid duplication of efforts.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Mechanisms of exacerbation of COVID-19 pathogenesis in mice expressing human ACE2 by polycyclic aromatic hydrocarbons (PAHs), and its protection by inhibition of soluble epoxide hydrolase (sEH)
-
批准号:10156460
-
项目类别:
-
资助金额:$24.07万
-
财政年份:2021
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
Mechanisms of exacerbation of COVID-19 pathogenesis in mice expressing human ACE2 by polycyclic aromatic hydrocarbons (PAHs), and its protection by inhibition of soluble epoxide hydrolase (sEH)
-
批准号:10337295
-
项目类别:
-
资助金额:$20.06万
-
财政年份:2021
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
POLYCYCLIC AROMATIC HYDROCARBONS: ULTRASENSITIVE DETECTION, EARLY LIFE EXPOSURES-CLINICAL OUTCOMES (PRETERM BIRTHS, CHRONIC LUNG DISEASE, AND NEUROCOGNITIVE DEFICITS), PREVENTION AND REMEDIATION
-
批准号:10401127
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2020
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
Proj3:Role of cytochrome P450 (CYP)1A/1B1 enzymes in the potentiation of neonatal lung injury in newbron mice exposed prenatally to PHs, and increased risk of premature infants to chronic lung disease
-
批准号:10116394
-
项目类别:
-
资助金额:$36.09万
-
财政年份:2020
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
Proj3:Role of cytochrome P450 (CYP)1A/1B1 enzymes in the potentiation of neonatal lung injury in newbron mice exposed prenatally to PHs, and increased risk of premature infants to chronic lung disease
-
批准号:10559705
-
项目类别:
-
资助金额:$36.09万
-
财政年份:2020
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
POLYCYCLIC AROMATIC HYDROCARBONS: ULTRASENSITIVE DETECTION, EARLY LIFE EXPOSURES-CLINICAL OUTCOMES (PRETERM BIRTHS, CHRONIC LUNG DISEASE, AND NEUROCOGNITIVE DEFICITS), PREVENTION AND REMEDIATION
-
批准号:10382017
-
项目类别:
-
资助金额:$1.61万
-
财政年份:2020
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
POLYCYCLIC AROMATIC HYDROCARBONS: ULTRASENSITIVE DETECTION, EARLY LIFE EXPOSURES-CLINICAL OUTCOMES (PRETERM BIRTHS, CHRONIC LUNG DISEASE, AND NEUROCOGNITIVE DEFICITS), PREVENTION AND REMEDIATION
-
批准号:10559666
-
项目类别:
-
资助金额:$175.1万
-
财政年份:2020
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
Core A: Administrative and Research Translation Core (ARTC)
-
批准号:10116385
-
项目类别:
-
资助金额:$16.01万
-
财政年份:2020
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
POLYCYCLIC AROMATIC HYDROCARBONS: ULTRASENSITIVE DETECTION, EARLY LIFE EXPOSURES-CLINICAL OUTCOMES (PRETERM BIRTHS, CHRONIC LUNG DISEASE, AND NEUROCOGNITIVE DEFICITS), PREVENTION AND REMEDIATION
-
批准号:10116383
-
项目类别:
-
资助金额:$175.1万
-
财政年份:2020
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
Mechanistic role of P4501 enzymes in the prevention of PAH carcinogenesis by omega 3 fatty acids
-
批准号:10163846
-
项目类别:
-
资助金额:$45.14万
-
财政年份:2018
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
Mechanistic role of P4501 enzymes in the prevention of PAH carcinogenesis by omega 3 fatty acids
-
批准号:10404072
-
项目类别:
-
资助金额:$44.89万
-
财政年份:2018
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
Mechanistic roles of Cytochrome P4501A enzymes in hyperoxic lung injury
-
批准号:9127549
-
项目类别:
-
资助金额:$54.03万
-
财政年份:2016
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
Functional roles of Nrf2 and NQO1 genetic variants in hyperoxic lung injury-ARDS
-
批准号:8786596
-
项目类别:
-
资助金额:$57.1万
-
财政年份:2012
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
Functional roles of Nrf2 and NQO1 genetic variants in hyperoxic lung injury-ARDS
-
批准号:8255907
-
项目类别:
-
资助金额:$60.14万
-
财政年份:2012
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
Functional roles of Nrf2 and NQO1 genetic variants in hyperoxic lung injury-ARDS
-
批准号:8603280
-
项目类别:
-
资助金额:$57.06万
-
财政年份:2012
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
Functional roles of Nrf2 and NQO1 genetic variants in hyperoxic lung injury-ARDS
-
批准号:8403926
-
项目类别:
-
资助金额:$55.67万
-
财政年份:2012
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
Role of cytochrome P4501B1 in oxygen-mediated pulmonary injury
-
批准号:8204511
-
项目类别:
-
资助金额:$42.06万
-
财政年份:2010
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
Role of cytochrome P4501B1 in oxygen-mediated pulmonary injury
-
批准号:8050391
-
项目类别:
-
资助金额:$44.84万
-
财政年份:2010
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
Role of cytochrome P4501B1 in oxygen-mediated pulmonary injury
-
批准号:8391741
-
项目类别:
-
资助金额:$41.19万
-
财政年份:2010
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
Role of cytochrome P4501B1 in oxygen-mediated pulmonary injury
-
批准号:8586889
-
项目类别:
-
资助金额:$41.59万
-
财政年份:2010
-
负责人:BHAGAVATULA MOORTHY
-
依托单位:
海外基金