Core A: Administrative and Research Translation Core (ARTC)

核心 A：行政和研究翻译核心 (ARTC)

• 批准号: 10559668
• 负责人: BHAGAVATULA MOORTHY
• 金额: $ 16.01万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-28 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10559668
• 关键词: 3-Dimensional; Address; Advisory Committees; Area; Aromatic Polycyclic Hydrocarbons; Biological Markers; Birth Rate; Bronchopulmonary Dysplasia; Businesses; Child; Chronic lung disease; Clinical; Collaborations; Committee Members; Communication; Communities; Country; County; Creativeness; Data; Data Analyses; Detection; Development; Discipline; Education; Ensure; Environmental Engineering technology; Environmental Health; Epidemiology; Exposure to; Feedback; Fostering; Goals; Government; Government Agencies; Grant; Health; Health Professional; Information Dissemination; Interdisciplinary Communication; Leadership; Legal patent; Life; Maternal Exposure; Medical; Medical center; Medicine; Morbidity - disease rate; National Institute of Environmental Health Sciences; Neurocognitive Deficit; Newsletter; Occupational activity of managing finances; Office of Administrative Management; Organizational Efficiency; Outcome; Patients; Persons; Play; Poison; Pregnant Women; Premature Birth; Premature Infant; Prevention; Public Health; Research; Research Project Grants; Research Support; Resources; Rice; Risk; Risk Assessment; Risk Factors; Role; Science; Sister; Site; Soil; Superfund; System; Technology Transfer; Texas; Toddler; Training; Training Programs; Translational Research; United States Environmental Protection Agency; Universities; Update; Water; Work; college; community center; community engagement; data management; data sharing; disease registry; early life exposure; experience; improved; investigator-initiated translational research; meetings; member; organizational structure; population based; programs; remediation; risk minimization; science teacher; success; superfund site; translational potential; web site; webinar

PROJECT SUMMARY The preterm birth rate in Harris County, Houston, TX is an alarming 13.6% (national average in US is 9.6%), and in areas surrounding Superfund sites, the preterm birth (PTB) rate is even higher (>20%). There are 15 Superfund sites in Harris County, posing a significant health risk to people living in the vicinity of these sites. PTB often leads to many complications, including chronic lung disease, also termed bronchopulmonary dysplasia (BPD), and some of these patients develop neurocognitive deficits later in life. One of the possible risk factors for PTB are polycyclic aromatic hydrocarbons (PAHs), present in contaminated soil, sediments, and water at various Superfund sites across the US, including in the greater Houston area. The over-arching hypothesis of the BCM-Rice Superfund Research Program (SRP) is that maternal exposure to PAHs, which are present in Superfund sites, increases the risk of PTB and incrementally augments major morbidities such as BPD and neurocognitive deficits. The leaders of the Administrative and Research Translation Core (AC), Drs. Bhagavatula Moorthy (Director), Pedro Alvarez (Deputy Director), Kjersti Aagaard, and Naomi Halas (Associate Directors) will bring their collective scientific, educational, and leadership experience to guide the Baylor-Rice SRP and address Superfund directives. The Administrative Core (AC) acts as the center of communication within the Center, responsible for creating an efficient organizational structure. To this end, the Core will facilitate interdisciplinary communication, collaboration, and integration of the Center’s Research Projects and cores. Further, the Administrative Core will explore creative ways to promote investigator-initiated research translation (IIRT) opportunities with assistance from the Research Translation Coordinators, Dr. Mellissa Bondy, and the co-coordinator Dr. Philip Lupo. The AC will also play a key role in the communication with various external stakeholders, including NIEHS and EPA, as well as with community partners, in close collaboration with the Community Engagement Core (CEC). The AC will also take an active role with the Research Experience and Training Coordination Core (RETCC) to create a vibrant training program and foster the development of environmental health and science professionals. The Administrative Core will ensure financial responsibility and management of the Center as well as work with the Data Management and Analysis Core (DMAC) to ensure responsible management of data. This will include working with the Project and Core Leaders, Office of Research, and Departments to ensure accomplishment of the proposed aims. The AC will also collaborate with sister SRPs as needed and will leverage support and resources so the goals of the BCM-Rice SRP are accomplished in a timely and efficient manner and avoid duplication of efforts.

项目摘要 德克萨斯州休斯顿哈里斯县的早产率达到惊人的13.6%（美国全国平均水平为9.6%）， 在超级基金所在地周围地区，早产率甚至更高（>20%）。有15 哈里斯县的超级基金场地，对居住在这些场地附近的人们构成重大健康风险。 肺结核常导致许多并发症，包括慢性肺病，也称为支气管肺发育不良 (BPD)其中一些患者在以后的生活中出现神经认知缺陷。可能的风险因素之一 对于PTB是多环芳烃（PAH），存在于污染的土壤，沉积物和水中， 在美国各地的各种超级基金网站，包括在大休斯顿地区。过度膨胀假说 英国生物医学委员会-水稻超级基金研究计划（SRP）是母亲暴露于多环芳烃，这是目前在 超级基金网站，增加了PTB的风险，并逐步增加主要的发病率，如BPD和 神经认知缺陷行政和研究翻译核心（AC）的领导人，博士。 Bhagavatula Moorthy（主任）、Pedro Alvarez（副主任）、Kjersti Aagaard和Naomi Halas（协理 董事）将带来他们的集体科学，教育和领导经验，以指导贝勒赖斯 SRP和解决超级基金指令。行政核心（AC）是沟通的中心 在中心内，负责建立一个有效的组织结构。为此，核心将促进 跨学科的交流，合作和中心的研究项目和核心的整合。 此外，行政核心将探索创造性的方法，以促进翻译发起的研究翻译 （IIRT）的机会与研究翻译协调员，博士梅利莎邦迪，和 菲利普·卢柏博士AC还将在与各种外部沟通中发挥关键作用 利益相关者，包括NIEHS和EPA，以及社区合作伙伴，与 社区参与核心（CEC）。AC还将在研究经验方面发挥积极作用， 培训协调核心（RETCC）创建一个充满活力的培训计划，并促进 环境卫生和科学专业人员。行政核心将确保财务责任， 管理中心，并与数据管理和分析核心（DMAC）合作，以确保 负责数据管理。这将包括与项目和核心领导人， 研究和部门，以确保实现拟议的目标。AC还将与 根据需要建立姐妹SRP，并将利用支持和资源，因此BCM-Rice SRP的目标是 及时和有效地完成，避免工作重复。