POLYCYCLIC AROMATIC HYDROCARBONS: ULTRASENSITIVE DETECTION, EARLY LIFE EXPOSURES-CLINICAL OUTCOMES (PRETERM BIRTHS, CHRONIC LUNG DISEASE, AND NEUROCOGNITIVE DEFICITS), PREVENTION AND REMEDIATION

多环芳烃：超灵敏检测、生命早期暴露-临床结果（早产、慢性肺病和神经认知缺陷）、预防和补救

• 批准号: 10116383
• 负责人: BHAGAVATULA MOORTHY
• 金额: $ 175.1万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-28 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10116383
• 关键词: Address; Adult; Aerosols; Air; Area; Aromatic Polycyclic Hydrocarbons; Biological; Biomedical Research; Birth Rate; Bronchopulmonary Dysplasia; Chemicals; Child; Childhood; Chronic lung disease; Cities; Clinical; Collaborations; County; Data; Data Analyses; Detection; Devices; Dust; Ecology; Engineering; Enrollment; Environment; Environmental Health; Evaluation; Exposure to; Fostering; Goals; Hazardous Chemicals; Hazardous Substances; Health; Human; Intervention; Lead; Life; Maternal Exposure; Measures; Methods; Molecular; Morbidity - disease rate; National Institute of Environmental Health Sciences; Neonatal; Neurocognitive Deficit; Optics; Oregon; Outcome; Patients; Physicians; Placenta; Postdoctoral Fellow; Premature Birth; Premature Infant; Prevention; Public Health; Research; Research Personnel; Research Project Grants; Research Support; Resources; Rice; Risk; Risk Assessment; Risk Factors; Sampling; Scientist; Sister; Site; Soil; Spectrum Analysis; Superfund; Surface; Technology; Technology Transfer; Testing; Texas; Toxic effect; Training; Translational Research; Water; Woman; Wrist; absorption; base; commercialization; community engagement; data management; detection method; early life exposure; experience; innovation; nanomaterials; next generation; novel; novel strategies; prevent; programs; public health emergency; remediation; student training; superfund site; wasting

Project Summary: The preterm birth rate in Harris County, Houston, TX is an alarming 13.6% (national average in US is 9.6%), and in areas surrounding the superfund sites, the preterm birth (PTB) rate is even higher (> 20%). There are 15 superfund sites in Harris County, posing a significant health risk to people living in the vicinity of these sites. Preterm birth (PTB) often leads to many complications including chronic lung disease, also termed bronchopulmonary dysplasia (BPD), and some of these patients develop neurocognitive deficits later in life. One of the possible risk factors for PTBs are polycyclic aromatic hydrocarbons (PAHs), present in contaminated soil, sediments, and water at various superfund sites across the US, including the greater Houston area. The over-arching hypothesis of the BCM-Rice SRP is that maternal exposure to PAHs, which are present in superfund sites, increases the risk of PTBs and incrementally augments major morbidities such as BPD and neurocognitive deficits. The Specific Aims of the overall center are: 1. To develop ultrasensitive detection and identification strategies (e.g., surface- enhanced Raman Spectra (SERA) and surface-enhanced Infrared Absorption spectroscopy (SEIRA) for primary and secondary PAH-based compounds in air, water, and soil based on optically active engineered nanomaterials (project 1). This method is highly innovative and because it can detect PAHs at 1 ppb levels, it will be very helpful for risk assessment. 2. To determine molecular mechanisms by which maternal exposure to PAH mixtures increases the risks for PTBs, which in turn leads to BPD and neurocognitive deficits. 3. To develop novel remediation technologies to treat sediments from Superfund sites in a manner that completely removes the health risks while adding value to the impacted media. This research should help in risk assessment. 4. To develop novel strategies to prevent and reduce the health burden associated with PAHs present in superfund sites (e.g., Patrick Bayou, San Jacinto waste Pitts) through our Community Engagement Core (CEC). 5. To develop partnerships with primary stakeholders (i.e. EPA, ATSDR), NIEHS, investigators within the center and other centers, to explore commercialization possibilities through the Administrative and Research Translational Core (AC). 6. Train students and postdoctoral fellows in a cross-disciplinary manner, so next generation scientists, engineers, and physicians will make fundamental contributions to Environmental Health [Research Experience and Training Coordination Core (RETCC)]. 7. To support the management and integration of assets across all the projects and cores of the center [data management and Analysis core (DMAC)]. The biomedical and environmental Science projects are well integrated, and they will be supported by the AC, the research support core (RSC), and the DMAC. The overall goal to reduce the health burden associated with PAHs in superfund sites.

项目概要： 德克萨斯州休斯敦哈里斯县的早产率高达 13.6%（美国全国平均水平为 9.6%），而在超级基金所在地周边地区，早产率（PTB）甚至更高（>20%）。 哈里斯县有 15 个超级基金站点，对居住在该县的人们构成重大健康风险 这些地点的附近地区。早产（PTB）通常会导致许多并发症，包括慢性肺病 疾病，也称为支气管肺发育不良（BPD），其中一些患者出现 晚年的神经认知缺陷。 PTB 的可能风险因素之一是多环芳香族化合物 碳氢化合物 (PAH)，存在于各个超级基金站点受污染的土壤、沉积物和水中 覆盖美国各地，包括大休斯顿地区。 BCM-Rice SRP 的总体假设 母亲接触超级基金场所中存在的多环芳烃会增加患肺结核的风险， 逐渐增加主要发病率，例如 BPD 和神经认知缺陷。具体目标 整个中心的目标是： 1. 开发超灵敏检测和识别策略（例如表面- 增强拉曼光谱 (SERA) 和表面增强红外吸收光谱 (SEIRA) 空气、水和土壤中基于光学活性的初级和次级 PAH 化合物 工程纳米材料（项目1）。这种方法具有高度创新性，因为它可以检测PAHs 在1 ppb水平时，对于风险评估将非常有帮助。 2. 确定分子机制 母亲接触 PAH 混合物会增加患 PTB 的风险，进而导致 BPD 和 神经认知缺陷。 3. 开发新的修复技术来处理超级基金的沉积物 网站的方式完全消除健康风险，同时为受影响的媒体增加价值。 这项研究应该有助于风险评估。 4. 制定新策略来预防和减少 与超级基金场所中存在的 PAH 相关的健康负担（例如帕特里克河口、圣哈辛托废物 Pitts）通过我们的社区参与核心（CEC）。 5. 与基层建立伙伴关系 利益相关者（即 EPA、ATSDR）、NIEHS、该中心和其他中心的研究人员，共同探索 通过行政和研究转化核心（AC）实现商业化的可能性。 6. 以跨学科的方式培训学生和博士后研究员，以便下一代科学家， 工程师和医生将为环境健康做出根本性贡献[研究 经验和培训协调核心（RETCC）]。 7.支持管理和整合 跨所有项目和中心核心的资产[数据管理和分析核心（DMAC）]。 生物医学和环境科学项目很好地结合在一起，它们将得到 AC、研究支持核心 (RSC) 和 DMAC。减轻健康负担的总体目标 与超级基金站点中的 PAH 相关。