Core A: Administrative and Research Translation Core (ARTC)

核心 A：行政和研究翻译核心 (ARTC)

• 批准号: 10116385
• 负责人: BHAGAVATULA MOORTHY
• 金额: $ 16.01万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-28 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10116385
• 关键词: 3-Dimensional; Address; Advisory Committees; Area; Aromatic Polycyclic Hydrocarbons; Biological Markers; Birth Rate; Bronchopulmonary Dysplasia; Businesses; Child; Chronic lung disease; Clinical; Collaborations; Committee Members; Communication; Communities; Country; County; Data; Data Analyses; Detection; Development; Discipline; Ensure; Environmental Engineering technology; Environmental Health; Epidemiology; Exposure to; Feedback; Fostering; Goals; Government; Government Agencies; Grant; Health; Health Professional; Information Dissemination; Interdisciplinary Communication; Investigator-Initiated Research; Leadership; Legal patent; Life; Maternal Exposure; Medical; Medical center; Medicine; Morbidity - disease rate; National Institute of Environmental Health Sciences; Neurocognitive Deficit; Newsletter; Occupational activity of managing finances; Outcome; Patients; Play; Poison; Pregnant Women; Premature Birth; Premature Infant; Prevention; Public Health; Research; Research Project Grants; Research Support; Resources; Rice; Risk; Risk Assessment; Risk Factors; Role; Science; Sister; Site; Soil; Superfund; System; Technology Transfer; Texas; Time; Toddler; Training; Training Programs; Translational Research; United States Environmental Protection Agency; Universities; Update; Water; Work; base; cohesion; college; community center; community engagement; data management; data sharing; disease registry; early life exposure; experience; meetings; member; organizational structure; population based; programs; remediation; risk minimization; science teacher; success; superfund site; web site; webinar

PROJECT SUMMARY The preterm birth rate in Harris County, Houston, TX is an alarming 13.6% (national average in US is 9.6%), and in areas surrounding Superfund sites, the preterm birth (PTB) rate is even higher (>20%). There are 15 Superfund sites in Harris County, posing a significant health risk to people living in the vicinity of these sites. PTB often leads to many complications, including chronic lung disease, also termed bronchopulmonary dysplasia (BPD), and some of these patients develop neurocognitive deficits later in life. One of the possible risk factors for PTB are polycyclic aromatic hydrocarbons (PAHs), present in contaminated soil, sediments, and water at various Superfund sites across the US, including in the greater Houston area. The over-arching hypothesis of the BCM-Rice Superfund Research Program (SRP) is that maternal exposure to PAHs, which are present in Superfund sites, increases the risk of PTB and incrementally augments major morbidities such as BPD and neurocognitive deficits. The leaders of the Administrative and Research Translation Core (AC), Drs. Bhagavatula Moorthy (Director), Pedro Alvarez (Deputy Director), Kjersti Aagaard, and Naomi Halas (Associate Directors) will bring their collective scientific, educational, and leadership experience to guide the Baylor-Rice SRP and address Superfund directives. The Administrative Core (AC) acts as the center of communication within the Center, responsible for creating an efficient organizational structure. To this end, the Core will facilitate interdisciplinary communication, collaboration, and integration of the Center’s Research Projects and cores. Further, the Administrative Core will explore creative ways to promote investigator-initiated research translation (IIRT) opportunities with assistance from the Research Translation Coordinators, Dr. Mellissa Bondy, and the co-coordinator Dr. Philip Lupo. The AC will also play a key role in the communication with various external stakeholders, including NIEHS and EPA, as well as with community partners, in close collaboration with the Community Engagement Core (CEC). The AC will also take an active role with the Research Experience and Training Coordination Core (RETCC) to create a vibrant training program and foster the development of environmental health and science professionals. The Administrative Core will ensure financial responsibility and management of the Center as well as work with the Data Management and Analysis Core (DMAC) to ensure responsible management of data. This will include working with the Project and Core Leaders, Office of Research, and Departments to ensure accomplishment of the proposed aims. The AC will also collaborate with sister SRPs as needed and will leverage support and resources so the goals of the BCM-Rice SRP are accomplished in a timely and efficient manner and avoid duplication of efforts.

项目概要 德克萨斯州休斯敦哈里斯县的早产率高达 13.6%（美国全国平均水平为 9.6%）， 在超级基金站点周边地区，早产率 (PTB) 甚至更高 (>20%)。有15个 哈里斯县的超级基金站点，对居住在这些站点附近的人们构成重大健康风险。 PTB 通常会导致许多并发症，包括慢性肺病，也称为支气管肺发育不良 （BPD），其中一些患者在以后的生活中出现神经认知缺陷。可能的风险因素之一 PTB 是多环芳烃 (PAH)，存在于受污染的土壤、沉积物和水中 美国各地的各个超级基金地点，包括大休斯顿地区。总体假设是 BCM-Rice 超级基金研究计划 (SRP) 的目的是研究母亲接触 PAH 的情况，这些物质存在于 超级基金网站增加了 PTB 的风险，并逐渐增加了 BPD 和 神经认知缺陷。行政和研究翻译核心（AC）的领导，博士。 Bhagavatula Moorthy（主任）、Pedro Alvarez（副主任）、Kjersti Aagaard 和 Naomi Halas（副主任） 董事）将带来他们集体的科学、教育和领导经验来指导贝勒-赖斯大学 SRP 并解决超级基金指令。行政核心 (AC) 充当沟通中心 在中心内，负责创建高效的组织结构。为此，核心将促进 中心研究项目和核心的跨学科交流、协作和整合。 此外，行政核心将探索创造性的方法来促进研究者发起的研究翻译 (IIRT) 在研究翻译协调员 Mellissa Bondy 博士和 联合协调员 Philip Lupo 博士。审计委员会还将在与各种外部的沟通中发挥关键作用 包括 NIEHS 和 EPA 在内的利益相关者以及社区合作伙伴，与 社区参与核心（CEC）。审计委员会还将在研究经验和 培训协调核心 (RETCC) 创建充满活力的培训计划并促进发展 环境健康和科学专业人员。行政核心将确保财务责任和 中心的管理以及与数据管理和分析核心（DMAC）的合作，以确保 负责任的数据管理。这将包括与项目和核心领导者、办公室合作 研究和部门确保实现拟议目标。审计委员会还将与 根据需要制定姊妹 SRP，并将利用支持和资源，因此 BCM-Rice SRP 的目标是 及时有效地完成工作，避免重复工作。