Core A: Administrative and Research Translation Core (ARTC)

核心 A：行政和研究翻译核心 (ARTC)

• 批准号: 10116385
• 负责人: BHAGAVATULA MOORTHY
• 金额: $ 16.01万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-28 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10116385
• 关键词: 3-Dimensional; Address; Advisory Committees; Area; Aromatic Polycyclic Hydrocarbons; Biological Markers; Birth Rate; Bronchopulmonary Dysplasia; Businesses; Child; Chronic lung disease; Clinical; Collaborations; Committee Members; Communication; Communities; Country; County; Data; Data Analyses; Detection; Development; Discipline; Ensure; Environmental Engineering technology; Environmental Health; Epidemiology; Exposure to; Feedback; Fostering; Goals; Government; Government Agencies; Grant; Health; Health Professional; Information Dissemination; Interdisciplinary Communication; Investigator-Initiated Research; Leadership; Legal patent; Life; Maternal Exposure; Medical; Medical center; Medicine; Morbidity - disease rate; National Institute of Environmental Health Sciences; Neurocognitive Deficit; Newsletter; Occupational activity of managing finances; Outcome; Patients; Play; Poison; Pregnant Women; Premature Birth; Premature Infant; Prevention; Public Health; Research; Research Project Grants; Research Support; Resources; Rice; Risk; Risk Assessment; Risk Factors; Role; Science; Sister; Site; Soil; Superfund; System; Technology Transfer; Texas; Time; Toddler; Training; Training Programs; Translational Research; United States Environmental Protection Agency; Universities; Update; Water; Work; base; cohesion; college; community center; community engagement; data management; data sharing; disease registry; early life exposure; experience; meetings; member; organizational structure; population based; programs; remediation; risk minimization; science teacher; success; superfund site; web site; webinar

PROJECT SUMMARY The preterm birth rate in Harris County, Houston, TX is an alarming 13.6% (national average in US is 9.6%), and in areas surrounding Superfund sites, the preterm birth (PTB) rate is even higher (>20%). There are 15 Superfund sites in Harris County, posing a significant health risk to people living in the vicinity of these sites. PTB often leads to many complications, including chronic lung disease, also termed bronchopulmonary dysplasia (BPD), and some of these patients develop neurocognitive deficits later in life. One of the possible risk factors for PTB are polycyclic aromatic hydrocarbons (PAHs), present in contaminated soil, sediments, and water at various Superfund sites across the US, including in the greater Houston area. The over-arching hypothesis of the BCM-Rice Superfund Research Program (SRP) is that maternal exposure to PAHs, which are present in Superfund sites, increases the risk of PTB and incrementally augments major morbidities such as BPD and neurocognitive deficits. The leaders of the Administrative and Research Translation Core (AC), Drs. Bhagavatula Moorthy (Director), Pedro Alvarez (Deputy Director), Kjersti Aagaard, and Naomi Halas (Associate Directors) will bring their collective scientific, educational, and leadership experience to guide the Baylor-Rice SRP and address Superfund directives. The Administrative Core (AC) acts as the center of communication within the Center, responsible for creating an efficient organizational structure. To this end, the Core will facilitate interdisciplinary communication, collaboration, and integration of the Center’s Research Projects and cores. Further, the Administrative Core will explore creative ways to promote investigator-initiated research translation (IIRT) opportunities with assistance from the Research Translation Coordinators, Dr. Mellissa Bondy, and the co-coordinator Dr. Philip Lupo. The AC will also play a key role in the communication with various external stakeholders, including NIEHS and EPA, as well as with community partners, in close collaboration with the Community Engagement Core (CEC). The AC will also take an active role with the Research Experience and Training Coordination Core (RETCC) to create a vibrant training program and foster the development of environmental health and science professionals. The Administrative Core will ensure financial responsibility and management of the Center as well as work with the Data Management and Analysis Core (DMAC) to ensure responsible management of data. This will include working with the Project and Core Leaders, Office of Research, and Departments to ensure accomplishment of the proposed aims. The AC will also collaborate with sister SRPs as needed and will leverage support and resources so the goals of the BCM-Rice SRP are accomplished in a timely and efficient manner and avoid duplication of efforts.

项目总结 德克萨斯州休斯顿市哈里斯县的早产率高达13.6%(美国全国平均水平为9.6%)， 在超级基金网站周围的地区，早产率甚至更高(&gt；20%)。有15个 哈里斯县的超级基金遗址，对居住在这些遗址附近的人们构成重大健康风险。 肺结核通常会导致许多并发症，包括慢性肺部疾病，也称为支气管肺发育不良。 (BPD)，其中一些患者在晚年会出现神经认知障碍。可能的风险因素之一 PTB是多环芳烃(PAHs)，存在于受污染的土壤、沉积物和水中 美国各地的各种超级基金网站，包括大休斯顿地区。最重要的假设是 BCM-大米超级基金研究计划(SRP)是母亲对多环芳烃的暴露，存在于 超级基金网站，增加肺结核的风险，并逐渐增加主要疾病，如BPD和 神经认知缺陷。行政和研究翻译核心(AC)的领导，Dr。 Bhagavatula Moorthy(主任)、Pedro Alvarez(副主任)、KJersti Aagaard和Naomi Halas(助理 董事)将带来他们的集体科学、教育和领导经验来指导贝勒-赖斯 SRP和地址超级基金指令。行政核心(AC)是沟通的中心 在中心内，负责创建高效的组织结构。为此，核心将促进 中心研究项目和核心的跨学科交流、协作和整合。 此外，行政核心将探索创造性的方法来促进由调查员发起的研究翻译 (IIRT)机会由研究翻译协调员Mellissa Bondy博士和 共同协调人菲利普·卢波博士。交流电源还将在与各种外部设备的沟通中发挥关键作用 利益攸关方，包括NIEHS和EPA，以及社区合作伙伴，与 社区参与核心(CEC)。咨询委员会还将发挥积极作用，提供研究经验和 培训协调核心(RETCC)创建充满活力的培训计划，并促进 环境健康和科学专业人士。行政核心将确保财政责任和 中心的管理以及与数据管理和分析核心(DMAC)的合作，以确保 负责任地管理数据。这将包括与项目和核心领导合作，办公室 研究和部门，以确保实现拟议的目标。AC还将与 并将利用支持和资源，因此BCM-大米SRP的目标是 及时、高效地完成任务，避免重复劳动。