Administrative Core

行政核心

• 批准号: 10559477
• 负责人: Quan Lu
• 金额: $ 16.57万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-21 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10559477
• 关键词: Administrator; Advisory Committees; Animals; Climate; Cognition; Cognitive; Cognitive aging; Collaborations; Communication; Complex Mixtures; Computational Science; Data; Data Science; Decision Making; Detection; Elderly; Emergency response; Ensure; Environmental Engineering technology; Environmental Epidemiology; Environmental Health; Environmental Protection; Environmental Science; Faculty; Fostering; Future; Genetic; Goals; Government Agencies; Hazardous Substances; Health; Human; Information Dissemination; Infrastructure; Institution; Institutional Review Boards; Interdisciplinary Communication; Interdisciplinary Study; Leadership; Life; Massachusetts; Mentors; Metal exposure; Metals; Mission; Modeling; Molecular Genetics; Molecular Toxicology; Neurobiology; Newsletter; Policy Maker; Postdoctoral Fellow; Public Health; Public Health Schools; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk; Science; Scientist; Series; Source; Superfund; Technology; Technology Transfer; Time; Toxicology; Training; Translating; Translational Research; United States National Institutes of Health; Universities; Visit; Work; community center; data sharing; design; direct application; early life exposure; global environment; graduate student; human subject; human subject protection; improved; insight; meetings; member; multidisciplinary; podcast; programs; remediation; social media; superfund site; symposium; technology development; tool; translational approach; translational potential; web site; working group

SUMMARY/ ABSTRACT As the hub of our Superfund Research Center (SRC), the Administrative Core will advance our mission—to understand and mitigate the effects of exposures to metals and metal mixtures found at Superfund sites on late-life cognitive health—by providing executive oversight of all SRC activities, from scientific to fiscal to logistical to research translation. Based in the Department of Environmental Health at the Harvard T.H. Chan School of Public Health, the Administrative Core will comprise a Director (Dr. Quan Lu), Deputy Director (Dr. Julie Zimmerman of Yale University), Research Translation Coordinator (Dr. Katherine von Stackelberg), and Center Administrator and will be guided by an Executive Committee (comprising Project and Core Leaders) and an External Advisory Committee. The Core will provide leadership and coordination to ensure that all Research Project and Core activities align with the Superfund Research Program mandates and Superfund mission “to solve target problem(s) related to health effects, risk, detection, and/or remediation of hazardous substances.” The Administrative Core has four Specific Aims. In Aim 1, we will organize and coordinate intra- Center meetings and conferences, including regular seminars, monthly meetings with an Executive Committee, and yearly meetings with the External Advisory Committee (8 members, including subject matter experts and stakeholders). In Aim 2, we will organize seminars and meetings to serve as central integration for all members of the SRC community—professionals who bring diverse expertise in environmental epidemiology, genetics, molecular toxicology, environmental science and engineering, and computational and data science— to foster interactions that will strengthen existing collaborations, generate new ideas for future cross- disciplinary collaborations, and provide interdisciplinary research and translation opportunities for trainees. In Aim 3, we will provide central administration, fiscal management, and quality management to ensure research integrity, as well as compliance with NIH requirements for data and resource sharing and human and animal institutional review board requirements. In Aim 4 we will facilitate research translation through 1) effective communication within the SRC and with stakeholders, leveraging collaborations with regional SRCs (e.g., the Northeast regional Superfund trainee conference and the Complex Mixtures working group); 2) partnerships with government agencies, including a visiting scientist program with EPA; 3) technology transfer in conjunction with the Harvard Office of Technology Development and Yale Entrepreneurial Institute, and 4) information dissemination to broad audiences through channels including social media, newsletters, podcasts and videos. By providing an infrastructure that facilitates communication and integration across all Center components, the Administrative Core ensures effective integration of the SRC to better understand how early life exposures to metals influence later life cognition, potential remediation strategies in reducing risks, and the overall impact on public health.

总结/摘要 作为我们的超级基金研究中心（SRC）的中心，行政核心将推进我们的使命， 了解和减轻接触在超级基金场所发现的金属和金属混合物的影响， 晚年认知健康-通过提供所有SRC活动的行政监督，从科学到财政， 从后勤到研究翻译总部设在哈佛大学环境卫生系。陈 公共卫生学院的行政核心将包括一名主任（卢泉博士），副主任（卢博士）， 耶鲁大学的朱莉齐默尔曼），研究翻译协调员（凯瑟琳冯斯塔克伯格博士），和 中心管理员，并将由执行委员会（包括项目和核心领导人）指导 一个外部咨询委员会。核心将提供领导和协调，以确保所有 研究项目和核心活动与超级基金研究计划任务和超级基金保持一致 使命“解决与健康影响、风险、检测和/或补救危险 物质”。行政核心有四个具体目标。在目标1中，我们将组织和协调内部- 中心会议，包括定期研讨会，每月与执行委员会会议， 与外部咨询委员会（8名成员，包括专题专家和 利益相关者）。在目标2中，我们将组织研讨会和会议，作为所有人的核心整合 SRC社区专业人员的成员，他们带来了环境流行病学方面的各种专业知识， 遗传学、分子毒理学、环境科学与工程、计算与数据科学- 促进互动，加强现有的合作，产生新的想法，为未来的交叉， 学科合作，并为学员提供跨学科的研究和翻译机会。在 目标3，我们将提供中央行政，财政管理和质量管理，以确保研究 完整性，以及遵守NIH对数据和资源共享以及人类和动物的要求 机构审查委员会的要求。在目标4中，我们将通过1）有效的 SRC内部以及与利益相关方的沟通，利用与区域SRC的合作（例如，的 东北地区超级基金培训生会议和复杂混合物工作组）; 2）伙伴关系 与政府机构，包括访问科学家计划与环保署; 3）技术转让， 与哈佛技术发展办公室和耶鲁创业学院合作，以及4） 通过社交媒体、时事通讯、播客等渠道向广大受众传播信息 和视频.通过提供一个基础设施，促进所有中心之间的通信和集成， 管理核心确保SRC的有效整合，以更好地了解如何尽早 生活中暴露于金属影响以后的生活认知，降低风险的潜在补救策略， 对公众健康的整体影响。