Metals and Metal Mixtures: Cognitive Aging, Remediation and Exposure Sources (MEMCARE)

金属和金属混合物：认知老化、修复和暴露源 (MEMCARE)

• 批准号: 10332724
• 负责人: Quan Lu
• 金额: $ 159.52万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-21 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10332724
• 关键词: 3-Dimensional; Address; Adult; Affect; Age; Aging; Animals; Behavior assessment; Benefits and Risks; Bioinformatics; Biological; Biomedical Research; Biometry; Boston; Brain; Child; Cognitive; Cognitive aging; Collaborations; Colorado; Communities; Complement; Data Analyses; Elderly; Engineering; Ensure; Environment; Environmental Engineering technology; Environmental Science; Epigenetic Process; Evaluation; Goals; Health; Heavy Metals; Human; Hybrids; Impaired cognition; In Vitro; Industrialization; Intervention; Lead; Life; Memory Loss; Metal exposure; Metals; Methods; MicroRNAs; Modeling; Municipalities; Nanostructures; Organoids; Outcome; Pattern; Population; Predisposition; Prevention strategy; Privatization; Public Health; Regulation; Reproducibility; Research; Research Project Grants; Resource Sharing; Risk; Risk Assessment; Risk Management; Role; Rural Community; Science; Source; Superfund; Support System; Surface; System; Technology; Testing; Therapeutic; Tooth structure; Training; United States; Urban Community; Water; Water Supply; Work; base; cognitive function; community engagement; cost; data management; design; drinking water; early life exposure; experience; extracellular vesicles; field study; ground water; improved; in vivo; innovation; metal poisoning; neurotoxic; novel; pollutant; postnatal; prenatal exposure; programs; remediation; superfund site; toxicant; treatment strategy

SUMMARY/ ABSTRACT Health concerns of aging—especially cognitive decline and memory loss in older age—have huge public health implications as the United States and world populations are shifting in distribution toward older ages. While a variety of toxicants contribute to cognitive aging, we are focused on heavy metals (Pb, As, Mn, Cd, Cr, and Se) and metal mixtures because, despite years of regulation, clean-up, and remediation efforts, metal contamination in many Superfund sites persists and continues to threaten public health. To our knowledge, there is no current Superfund Research Center (SRC) that specifically addresses the health effects, risk, and remediation of metal contaminants in relation to their effects on cognitive health in older age. To fill this critical gap and to address the pressing public health problems posed by environmental metal contaminants on cognitive aging, we propose a new SRC entitled Metals and Metal Mixtures: Cognitive Aging, Remediation and Exposure Sources (MEMCARE). The overall goal of MEMCARE-SRC is to understand and mitigate effects of exposure to metals and metal mixtures on late-life cognitive health. To achieve this goal, we have designed a highly integrated, solution-based program of 4 Research Projects and 4 Cores. Project 1 uses an innovative approach to assess early-life exposures and late-life cognitive function in a unique population of adults now in their 60s and 70s who donated baby teeth as children. Project 2 investigates basic biological mechanisms underlying effects of early-life exposures using both in vitro and in vivo approaches. Project 3 examines the role of surface and groundwater treatment systems in spatial and temporal patterns of metals in water across the US, including Superfund sites. Project 4 will develop novel nanostructured adsorbents to remove metals from water, potentially providing improved remedies for our populations in Project 1 and the Community Engagement Core (CEC). Our CEC will partner with an urban, industrially-contaminated community in Boston, MA, and a rural community directly affected by two Superfund sites in Colorado. The Data Management and Analysis Core (DMAC) will provide data management, biostatistical, and bioinformatics support and ensure resource sharing and reproducible science for all Projects and Cores. The Administrative Core will provide oversight and communicate our science to stakeholders. The Research Experience and Training Coordination Core (RETCC) will embed with all aspects of our Center to provide doctoral and postdoctoral trainees with relevant experiences in all aspects of work in the SRC.

摘要/摘要 衰老的健康问题，尤其是老年人的认知能力下降和记忆力丧失 - 巨大的公共卫生 作为美国和世界人口的含义正在分配向老年人转移。而a 多种毒物有助于认知衰老，我们专注于重金属（PB，AS，MN，CD，CR和SE） 和金属混合物，因为目的地的调节，清理和补救工作，金属 许多超级基金站点的污染仍然存在，并继续威胁到公共卫生。据我们所知， 目前没有专门针对健康影响，风险和 金属污染物对其对老年认知健康的影响的修复。填补这个关键 差距并解决环境金属污染物对公共卫生问题的紧迫公共卫生问题 认知衰老，我们提出了一种新的SRC，标题为“金属和金属混合物：认知衰老，修复和 暴露来源（Memcare）。 memcare-SRC的总体目标是了解和减轻影响的影响 在晚期认知健康中接触金属和金属混合物。为了实现这一目标，我们设计了 高度集成，基于解决方案的计划，包括4个研究项目和4个核心。项目1使用创新 评估现在独特的成年人人群的早期暴露和晚期认知功能的方法 他们的60年代和70多岁的孩子小时候捐赠了乳牙。项目2研究基本的生物学机制 使用体外和体内方法的早期暴露的潜在影响。项目3检查 表面和地下水处理系统在水中金属的空间和临时模式中的作用 美国，包括超级基金网站。项目4将开发新颖的纳米结构吸附剂来去除金属 从水中，有可能在项目1和社区中为我们的人口提供改进的补救措施 参与核心（CEC）。我们的CEC将与波士顿的城市，工业污染社区合作 MA，以及一个直接受科罗拉多州两个超级基金网站影响的粗糙社区。数据管理和 分析核心（DMAC）将提供数据管理，生物统计学和生物信息学支持，并确保 所有项目和核心的资源共享和可再现科学。行政核心将提供 监督并将我们的科学传达给利益相关者。研究经验和培训协调 Core（RETCC）将嵌入我们中心的各个方面，为博士和博士后学员提供 SRC工作各个方面的相关经验。