Metals and Metal Mixtures: Cognitive Aging, Remediation and Exposure Sources (MEMCARE)

金属和金属混合物：认知老化、修复和暴露源 (MEMCARE)

• 批准号: 10559476
• 负责人: Quan Lu
• 金额: $ 159.52万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-21 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10559476
• 关键词: Address; Adult; Affect; Aging; Animals; Behavior assessment; Benefits and Risks; Bioinformatics; Biological; Biomedical Research; Biometry; Boston; Brain; Child; Cognitive; Cognitive aging; Collaborations; Colorado; Communication; Communities; Complement; Data Analyses; Elderly; Engineering; Ensure; Environment; Environmental Engineering technology; Environmental Science; Epigenetic Process; Evaluation; Goals; Health; Heavy Metals; Human; Hybrids; Impaired cognition; In Vitro; Industrialization; Intervention; Life; Memory Loss; Metal exposure; Metals; Methods; MicroRNAs; Modeling; Municipalities; Nanostructures; Organoids; Outcome; Pattern; Population; Postdoctoral Fellow; Predisposition; Prevention strategy; Privatization; Public Health; Regulation; Reproducibility; Research; Research Project Grants; Resource Sharing; Risk; Risk Assessment; Risk Management; Role; Rural Community; Science; Source; Superfund; Support System; Surface; System; Technology; Testing; Therapeutic; Tooth structure; Training; United States; Urban Community; Water; Water Supply; Work; cognitive function; community engagement; cost; data management; design; drinking water; early life exposure; experience; extracellular vesicles; field study; ground water; human old age (65+); improved; in utero; in vivo; innovation; metal poisoning; neurotoxic; novel; pollutant; postnatal; programs; remediation; superfund site; three dimensional cell culture; toxicant; treatment strategy

SUMMARY/ ABSTRACT Health concerns of aging—especially cognitive decline and memory loss in older age—have huge public health implications as the United States and world populations are shifting in distribution toward older ages. While a variety of toxicants contribute to cognitive aging, we are focused on heavy metals (Pb, As, Mn, Cd, Cr, and Se) and metal mixtures because, despite years of regulation, clean-up, and remediation efforts, metal contamination in many Superfund sites persists and continues to threaten public health. To our knowledge, there is no current Superfund Research Center (SRC) that specifically addresses the health effects, risk, and remediation of metal contaminants in relation to their effects on cognitive health in older age. To fill this critical gap and to address the pressing public health problems posed by environmental metal contaminants on cognitive aging, we propose a new SRC entitled Metals and Metal Mixtures: Cognitive Aging, Remediation and Exposure Sources (MEMCARE). The overall goal of MEMCARE-SRC is to understand and mitigate effects of exposure to metals and metal mixtures on late-life cognitive health. To achieve this goal, we have designed a highly integrated, solution-based program of 4 Research Projects and 4 Cores. Project 1 uses an innovative approach to assess early-life exposures and late-life cognitive function in a unique population of adults now in their 60s and 70s who donated baby teeth as children. Project 2 investigates basic biological mechanisms underlying effects of early-life exposures using both in vitro and in vivo approaches. Project 3 examines the role of surface and groundwater treatment systems in spatial and temporal patterns of metals in water across the US, including Superfund sites. Project 4 will develop novel nanostructured adsorbents to remove metals from water, potentially providing improved remedies for our populations in Project 1 and the Community Engagement Core (CEC). Our CEC will partner with an urban, industrially-contaminated community in Boston, MA, and a rural community directly affected by two Superfund sites in Colorado. The Data Management and Analysis Core (DMAC) will provide data management, biostatistical, and bioinformatics support and ensure resource sharing and reproducible science for all Projects and Cores. The Administrative Core will provide oversight and communicate our science to stakeholders. The Research Experience and Training Coordination Core (RETCC) will embed with all aspects of our Center to provide doctoral and postdoctoral trainees with relevant experiences in all aspects of work in the SRC.

摘要/摘要 老龄化带来的健康问题，尤其是老年认知能力下降和记忆力丧失，对公众健康产生巨大影响 随着美国和世界人口的分布向老龄化方向转变，这会产生影响。虽然一个 多种有毒物质会导致认知老化，我们重点关注重金属（Pb、As、Mn、Cd、Cr 和 Se） 和金属混合物，因为尽管经过多年的监管、清理和补救工作，金属 许多超级基金地点的污染持续存在，并继续威胁公众健康。据我们所知， 目前没有专门解决健康影响、风险和风险的超级基金研究中心 (SRC) 金属污染物的修复与其对老年人认知健康的影响有关。为了填补这个关键 差距并解决环境金属污染物造成的紧迫公共卫生问题 认知老化，我们提出了一个新的 SRC，题为金属和金属混合物：认知老化、修复和 暴露源 (MEMCARE)。 MEMCARE-SRC 的总体目标是了解并减轻以下因素的影响 接触金属和金属混合物对晚年认知健康的影响。为了实现这一目标，我们设计了一个 高度集成、基于解决方案的项目，由 4 个研究项目和 4 个核心组成。项目1采用了创新的 评估目前独特的成年人群体的早期暴露和晚年认知功能的方法 60 多岁和 70 多岁的人在小时候捐赠了乳牙。项目2研究基本生物学机制 使用体外和体内方法研究早期生命暴露的潜在影响。项目 3 检查 地表水和地下水处理系统对水中金属的时空格局的作用 美国，包括超级基金网站。项目 4 将开发新型纳米结构吸附剂来去除金属 来自水，有可能为项目 1 中的人们和社区提供改进的补救措施 参与核心（CEC）。我们的 CEC 将与波士顿一个受工业污染的城市社区合作， 马萨诸塞州，以及科罗拉多州两个超级基金站点直接影响的一个农村社区。数据管理和 分析核心（DMAC）将提供数据管理、生物统计和生物信息学支持并确保 所有项目和核心的资源共享和可重复的科学。行政核心将提供 监督并向利益相关者传达我们的科学。研究经验和培训协调 核心（RETCC）将嵌入我们中心的各个方面，为博士和博士后培训生提供 SRC各方面工作的相关经验。