Metals and Metal Mixtures: Cognitive Aging, Remediation and Exposure Sources (MEMCARE)
金属和金属混合物:认知老化、修复和暴露源 (MEMCARE)
基本信息
- 批准号:10559476
- 负责人:
- 金额:$ 159.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-02-21 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAffectAgingAnimalsBehavior assessmentBenefits and RisksBioinformaticsBiologicalBiomedical ResearchBiometryBostonBrainChildCognitiveCognitive agingCollaborationsColoradoCommunicationCommunitiesComplementData AnalysesElderlyEngineeringEnsureEnvironmentEnvironmental Engineering technologyEnvironmental ScienceEpigenetic ProcessEvaluationGoalsHealthHeavy MetalsHumanHybridsImpaired cognitionIn VitroIndustrializationInterventionLifeMemory LossMetal exposureMetalsMethodsMicroRNAsModelingMunicipalitiesNanostructuresOrganoidsOutcomePatternPopulationPostdoctoral FellowPredispositionPrevention strategyPrivatizationPublic HealthRegulationReproducibilityResearchResearch Project GrantsResource SharingRiskRisk AssessmentRisk ManagementRoleRural CommunityScienceSourceSuperfundSupport SystemSurfaceSystemTechnologyTestingTherapeuticTooth structureTrainingUnited StatesUrban CommunityWaterWater SupplyWorkcognitive functioncommunity engagementcostdata managementdesigndrinking waterearly life exposureexperienceextracellular vesiclesfield studyground waterhuman old age (65+)improvedin uteroin vivoinnovationmetal poisoningneurotoxicnovelpollutantpostnatalprogramsremediationsuperfund sitethree dimensional cell culturetoxicanttreatment strategy
项目摘要
SUMMARY/ ABSTRACT
Health concerns of aging—especially cognitive decline and memory loss in older age—have huge public health
implications as the United States and world populations are shifting in distribution toward older ages. While a
variety of toxicants contribute to cognitive aging, we are focused on heavy metals (Pb, As, Mn, Cd, Cr, and Se)
and metal mixtures because, despite years of regulation, clean-up, and remediation efforts, metal
contamination in many Superfund sites persists and continues to threaten public health. To our knowledge,
there is no current Superfund Research Center (SRC) that specifically addresses the health effects, risk, and
remediation of metal contaminants in relation to their effects on cognitive health in older age. To fill this critical
gap and to address the pressing public health problems posed by environmental metal contaminants on
cognitive aging, we propose a new SRC entitled Metals and Metal Mixtures: Cognitive Aging, Remediation and
Exposure Sources (MEMCARE). The overall goal of MEMCARE-SRC is to understand and mitigate effects of
exposure to metals and metal mixtures on late-life cognitive health. To achieve this goal, we have designed a
highly integrated, solution-based program of 4 Research Projects and 4 Cores. Project 1 uses an innovative
approach to assess early-life exposures and late-life cognitive function in a unique population of adults now in
their 60s and 70s who donated baby teeth as children. Project 2 investigates basic biological mechanisms
underlying effects of early-life exposures using both in vitro and in vivo approaches. Project 3 examines the
role of surface and groundwater treatment systems in spatial and temporal patterns of metals in water across
the US, including Superfund sites. Project 4 will develop novel nanostructured adsorbents to remove metals
from water, potentially providing improved remedies for our populations in Project 1 and the Community
Engagement Core (CEC). Our CEC will partner with an urban, industrially-contaminated community in Boston,
MA, and a rural community directly affected by two Superfund sites in Colorado. The Data Management and
Analysis Core (DMAC) will provide data management, biostatistical, and bioinformatics support and ensure
resource sharing and reproducible science for all Projects and Cores. The Administrative Core will provide
oversight and communicate our science to stakeholders. The Research Experience and Training Coordination
Core (RETCC) will embed with all aspects of our Center to provide doctoral and postdoctoral trainees with
relevant experiences in all aspects of work in the SRC.
摘要/摘要
老龄化带来的健康问题,尤其是老年认知能力下降和记忆力丧失,对公众健康产生巨大影响
随着美国和世界人口的分布向老龄化方向转变,这会产生影响。虽然一个
多种有毒物质会导致认知老化,我们重点关注重金属(Pb、As、Mn、Cd、Cr 和 Se)
和金属混合物,因为尽管经过多年的监管、清理和补救工作,金属
许多超级基金地点的污染持续存在,并继续威胁公众健康。据我们所知,
目前没有专门解决健康影响、风险和风险的超级基金研究中心 (SRC)
金属污染物的修复与其对老年人认知健康的影响有关。为了填补这个关键
差距并解决环境金属污染物造成的紧迫公共卫生问题
认知老化,我们提出了一个新的 SRC,题为金属和金属混合物:认知老化、修复和
暴露源 (MEMCARE)。 MEMCARE-SRC 的总体目标是了解并减轻以下因素的影响
接触金属和金属混合物对晚年认知健康的影响。为了实现这一目标,我们设计了一个
高度集成、基于解决方案的项目,由 4 个研究项目和 4 个核心组成。项目1采用了创新的
评估目前独特的成年人群体的早期暴露和晚年认知功能的方法
60 多岁和 70 多岁的人在小时候捐赠了乳牙。项目2研究基本生物学机制
使用体外和体内方法研究早期生命暴露的潜在影响。项目 3 检查
地表水和地下水处理系统对水中金属的时空格局的作用
美国,包括超级基金网站。项目 4 将开发新型纳米结构吸附剂来去除金属
来自水,有可能为项目 1 中的人们和社区提供改进的补救措施
参与核心(CEC)。我们的 CEC 将与波士顿一个受工业污染的城市社区合作,
马萨诸塞州,以及科罗拉多州两个超级基金站点直接影响的一个农村社区。数据管理和
分析核心(DMAC)将提供数据管理、生物统计和生物信息学支持并确保
所有项目和核心的资源共享和可重复的科学。行政核心将提供
监督并向利益相关者传达我们的科学。研究经验和培训协调
核心(RETCC)将嵌入我们中心的各个方面,为博士和博士后培训生提供
SRC各方面工作的相关经验。
项目成果
期刊论文数量(0)
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专利数量(0)
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{{ truncateString('Quan Lu', 18)}}的其他基金
Metals and Metal Mixtures: Cognitive Aging, Remediation and Exposure Sources (MEMCARE)
金属和金属混合物:认知老化、修复和暴露源 (MEMCARE)
- 批准号:
10580936 - 财政年份:2022
- 资助金额:
$ 159.52万 - 项目类别:
EV miRs in cognitive function decline associated with early life metal exposure
EV miRs与早期金属暴露相关的认知功能下降
- 批准号:
10112926 - 财政年份:2020
- 资助金额:
$ 159.52万 - 项目类别:
Metals and Metal Mixtures: Cognitive Aging, Remediation and Exposure Sources (MEMCARE)
金属和金属混合物:认知老化、修复和暴露源 (MEMCARE)
- 批准号:
10332724 - 财政年份:2020
- 资助金额:
$ 159.52万 - 项目类别:
Metals and Metal Mixtures: Cognitive Aging, Remediation and Exposure Sources (MEMCARE)
金属和金属混合物:认知老化、修复和暴露源 (MEMCARE)
- 批准号:
10112910 - 财政年份:2020
- 资助金额:
$ 159.52万 - 项目类别:
EV miRs in cognitive function decline associated with early life metal exposure
EV miRs与早期金属暴露相关的认知功能下降
- 批准号:
10332730 - 财政年份:2020
- 资助金额:
$ 159.52万 - 项目类别:
EV miRs in cognitive function decline associated with early life metal exposure
EV miRs与早期金属暴露相关的认知功能下降
- 批准号:
10559488 - 财政年份:2020
- 资助金额:
$ 159.52万 - 项目类别:
Metals and Metal Mixtures: Cognitive Aging, Remediation and Exposure Sources (MEMCARE)
金属和金属混合物:认知老化、修复和暴露源 (MEMCARE)
- 批准号:
10163335 - 财政年份:2020
- 资助金额:
$ 159.52万 - 项目类别:
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