An Ecological Investigation of Acute Next-Day Effects of Alcohol Use on Daily Cognitive Functioning

饮酒对日常认知功能的第二天急性影响的生态学调查

• 批准号: 10570499
• 负责人: Ashley Nicole Linden-Carmichael
• 金额: $ 23.06万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10570499
• 关键词: Activities of Daily Living; Acute; Age; Alcohol abuse; Alcohol consumption; Alcohols; Attention; Behavior; Brain; Buffers; Cannabis; Characteristics; Clinical; Cognition; Cognitive; Corpus Callosum; Data; Development; Early Intervention; Elderly; Episodic memory; Event; Female; Health; Heavy Drinking; Impaired cognition; Individual; Injury; Interruption; Intervention; Intoxication; Investigation; Light; Memory; Monitor; Moods; National Institute on Alcohol Abuse and Alcoholism; Outcome; Overdose; Patient Self-Report; Performance; Persons; Positioning Attribute; Prevention; Public Health; Reporting; Research; Risk; Role; Sampling; Severities; Short-Term Memory; Signal Transduction; Sleep; Strategic Planning; Subgroup; Symptoms; Time; United States Substance Abuse and Mental Health Services Administration; Work; age group; alcohol effect; alcohol measurement; alcohol risk; alcohol use disorder; binge drinking; cognitive function; cost estimate; diaries; drinking; executive function; experience; hangover; high intensity drinking; high risk; indexing; male; marijuana use; meetings; middle age; morphometry; sex; sexual assault; substance use; young adult

PROJECT SUMMARY/ABSTRACT Heavy and frequent alcohol use remains a key public health concern, particularly among young adults. Recent experimental evidence has shown that a single heavy drinking event is associated with short-term structural changes in the brain among a sample of young adults and preliminary diary evidence suggests alcohol use may impact concentration and working memory capacity. As young adults are at highest risk of alcohol use relative to any other age group, such immediate structural changes may signal a need for early prevention and intervention efforts, although the long-term impacts of alcohol use on the brain within a sample of young adults remain unknown. A key indicator of longer-term cognitive outcomes is observed functional impacts on young adult behavior in their daily lives. Changes in daily behaviors during this period could negatively impact cognitive health into midlife. Our team aims to collect intensive data across a 21-day period from a sample of 250 young adults to explore the acute, next-day (post-intoxication) effects of alcohol use on cognitive functioning overall, across multiple timeframes, and by type of drinking episode (light drinking, binge drinking, high-intensity drinking, blackout drinking). We also seek to examine day-level and person-level moderators to inform moments and subgroups at greatest risk and in need of early targeted prevention and intervention efforts. Specifically, the current exploratory and developmental R21 has three aims. Aim 1 will (a) examine acute, next-day effects of any alcohol use on cognitive functioning (episodic memory, executive functioning, working memory) and across various time frames (i.e., upon waking only or persisting throughout the day); and (b) examine whether these daily associations differ by type of drinking episode (light drinking, binge drinking, high-intensity drinking, blackout drinking). Aim 2 will examine day-level moderators (hangover symptoms, mood, sleep, prior day cannabis, other substance use) that may buffer or exacerbate day-level associations between alcohol use (any drinking, light drinking, binge drinking, high-intensity drinking, blackout drinking) and cognitive functioning. Finally, Aim 3 will examine person-level variables (sex, baseline alcohol use severity, general cognitive functioning) as moderators of day-level associations between alcohol use (any drinking, light drinking, binge drinking, high-intensity drinking, blackout drinking) and cognitive functioning. By identifying the acute impacts of varying levels of alcohol use intensity on next-day cognitive functioning as well as the day- and person-level characteristics that moderate these associations, our findings will have critical implications for the role of alcohol use on everyday cognitive functioning and highlight subgroups most in need of monitoring and early intervention. Findings from this exploratory and developmental R21 will also position our team well to ultimately examine whether day-level associations accumulate and are indicative of later alcohol-related and cognition-related problems.

项目概要/摘要 大量和频繁饮酒仍然是一个关键的公共卫生问题，特别是对于年轻人来说。最近的 实验证据表明，一次酗酒事件与短期结构性 年轻人样本中大脑的变化和初步日记证据表明饮酒可能 影响注意力和工作记忆容量。由于年轻人相对而言饮酒的风险最高 对于任何其他年龄组来说，这种直接的结构变化可能表明需要及早预防和预防 干预措施，尽管酒精使用对年轻人样本中大脑的长期影响 仍然未知。长期认知结果的一个关键指标是观察到对年轻人的功能影响 日常生活中的成人行为。在此期间日常行为的变化可能会产生负面影响 认知健康进入中年。我们的团队旨在从样本中收集 21 天内的密集数据 250 名年轻人探讨饮酒对认知的急性、次日（中毒后）影响 总体功能，跨多个时间范围，并按饮酒事件类型（轻度饮酒、酗酒、 高强度饮酒、停电饮酒）。我们还寻求检查日级和个人级主持人，以 告知面临最大风险并需要早期有针对性的预防和干预的时刻和亚群体 努力。具体来说，目前探索和开发的R21有三个目标。目标 1 将 (a) 检查 任何饮酒对认知功能（情景记忆、执行功能、 工作记忆）和跨不同时间范围（即仅醒来时或全天持续）；和 (b) 检查这些日常关联是否因饮酒事件的类型（轻度饮酒、酗酒、 高强度饮酒、停电饮酒）。目标 2 将检查日间调节因素（宿醉症状、 情绪、睡眠、前一天吸食大麻、其他物质使用）可能会缓冲或加剧日间关联 饮酒（任何饮酒、轻度饮酒、暴饮、高强度饮酒、停酒）和 认知功能。最后，目标 3 将检查个人层面的变量（性别、基线饮酒严重程度、 一般认知功能）作为酒精使用（任何饮酒、轻度饮酒）之间日间关联的调节因素 饮酒、暴饮、高强度饮酒、停顿饮酒）和认知功能。通过识别 不同程度的饮酒强度对第二天的认知功能以及白天的严重影响 以及调节这些关联的个人层面的特征，我们的研究结果将对 饮酒对日常认知功能的作用并强调最需要监测的亚组 和早期干预。这一探索性和开发性 R21 的发现也将使我们的团队能够很好地 最终检查日间关联是否积累并表明后来的酒精相关和 与认知相关的问题。