An Ecological Investigation of Acute Next-Day Effects of Alcohol Use on Daily Cognitive Functioning

项目总结/摘要 大量和频繁饮酒仍然是一个关键的公共卫生问题，特别是在年轻人中。最近 实验证据表明，一个单一的大量饮酒事件与短期的结构性 年轻人样本的大脑变化和初步日记证据表明，饮酒可能 影响注意力和工作记忆容量。由于年轻人饮酒的风险最高， 对于任何其他年龄组，这种直接的结构变化可能表明需要早期预防， 干预努力，虽然长期影响酒精使用对大脑的样本中的年轻人 仍然未知。长期认知结果的一个关键指标是观察到的对年轻人的功能影响 日常生活中的成人行为。在此期间，日常行为的变化可能会对 认知健康到中年我们的团队的目标是从一个样本中收集21天内的密集数据， 250名年轻人探索酒精使用对认知能力的急性次日（中毒后）影响 在多个时间范围内，以及按饮酒事件类型（轻度饮酒，酗酒， 高强度饮酒，停电饮酒）。我们还试图检查日级别和个人级别的主持人， 在最危险和需要早期有针对性的预防和干预的时刻和亚组提供信息 努力具体而言，目前的探索性和发展性R21有三个目标。目标1将（a）审查 任何酒精使用对认知功能（情节记忆，执行功能， 工作存储器）和跨各种时间帧（即，只在白天醒来或持续）。 (b)检查这些日常关联是否因饮酒事件的类型而不同（轻度饮酒，酗酒， 高强度饮酒，停电饮酒）。目标2将检查日常调节（宿醉症状， 情绪，睡眠，前一天大麻，其他物质的使用），这可能会缓冲或加剧一天的关联 酒精使用（任何饮酒，轻度饮酒，暴饮暴食，高强度饮酒，停电饮酒）和 认知功能最后，目标3将检查个人层面的变量（性别，基线酒精使用严重程度， 一般认知功能）作为日常饮酒（任何饮酒，轻度 饮酒、狂饮、高强度饮酒、无意识饮酒）和认知功能。通过识别 不同程度的酒精使用强度对第二天认知功能的急性影响， 以及调节这些关联的个人层面特征，我们的研究结果将对以下方面产生重要影响： 酒精使用对日常认知功能的作用，并强调最需要监测的亚组 早期干预。这项探索性和发展性R21的发现也将使我们的团队能够很好地 最终检查日常水平的关联是否会积累，并指示后来的酒精相关， 认知相关的问题。

PROJECT SUMMARY/ABSTRACT Heavy and frequent alcohol use remains a key public health concern, particularly among young adults. Recent experimental evidence has shown that a single heavy drinking event is associated with short-term structural changes in the brain among a sample of young adults and preliminary diary evidence suggests alcohol use may impact concentration and working memory capacity. As young adults are at highest risk of alcohol use relative to any other age group, such immediate structural changes may signal a need for early prevention and intervention efforts, although the long-term impacts of alcohol use on the brain within a sample of young adults remain unknown. A key indicator of longer-term cognitive outcomes is observed functional impacts on young adult behavior in their daily lives. Changes in daily behaviors during this period could negatively impact cognitive health into midlife. Our team aims to collect intensive data across a 21-day period from a sample of 250 young adults to explore the acute, next-day (post-intoxication) effects of alcohol use on cognitive functioning overall, across multiple timeframes, and by type of drinking episode (light drinking, binge drinking, high-intensity drinking, blackout drinking). We also seek to examine day-level and person-level moderators to inform moments and subgroups at greatest risk and in need of early targeted prevention and intervention efforts. Specifically, the current exploratory and developmental R21 has three aims. Aim 1 will (a) examine acute, next-day effects of any alcohol use on cognitive functioning (episodic memory, executive functioning, working memory) and across various time frames (i.e., upon waking only or persisting throughout the day); and (b) examine whether these daily associations differ by type of drinking episode (light drinking, binge drinking, high-intensity drinking, blackout drinking). Aim 2 will examine day-level moderators (hangover symptoms, mood, sleep, prior day cannabis, other substance use) that may buffer or exacerbate day-level associations between alcohol use (any drinking, light drinking, binge drinking, high-intensity drinking, blackout drinking) and cognitive functioning. Finally, Aim 3 will examine person-level variables (sex, baseline alcohol use severity, general cognitive functioning) as moderators of day-level associations between alcohol use (any drinking, light drinking, binge drinking, high-intensity drinking, blackout drinking) and cognitive functioning. By identifying the acute impacts of varying levels of alcohol use intensity on next-day cognitive functioning as well as the day- and person-level characteristics that moderate these associations, our findings will have critical implications for the role of alcohol use on everyday cognitive functioning and highlight subgroups most in need of monitoring and early intervention. Findings from this exploratory and developmental R21 will also position our team well to ultimately examine whether day-level associations accumulate and are indicative of later alcohol-related and cognition-related problems.