Simultaneous Alcohol and Marijuana Use: Momentary Influences and Consequences

项目摘要/摘要 指导研究科学家发展计划中提出的研究计划和量身定做的培训活动 获奖申请(K01)将使候选人Ashley N.Linden-Carmichael博士能够培养基本技能 来建立她的研究项目，并过渡到作为一名酒精调查员的独立。林登博士- Carmichael的工作使用了创新的方法论和统计技术，以获得对 年轻人表现出的高风险饮酒模式。目前的应用程序建立在她以前的工作基础上 作为国家研究服务奖(NRSA；F31)博士前研究员，研究新兴的公共卫生 关注：同时使用酒精和大麻(SAM)(即同时使用酒精和大麻)。 SAM的使用尤其有问题，因为使用这两种物质可以相互作用，产生协同作用 对减值的影响。拟议的研究活动旨在填补我们对SAM基本知识的几个空白 通过提供有关SAM使用模式的预测因素和后果的详细、即时信息来使用 通过创新使用可穿戴式酒精传感器和生态瞬时评估。具体来说， 提出的这两项研究旨在通过以下方式更好地理解SAM使用模式：(1)开发一种简单的测量方法 SAM在生态瞬时评估(EMA)调查中使用动机；(2)使用EMA识别 SAM使用的人、日和瞬间水平的预测；(3)应用新的密集纵向数据方法 描述SAM和纯酒精使用期间酒精中毒的动态特征；以及(4) 比较单独使用SAM和单独使用SAM的日水平后果。这 研究将在宾夕法尼亚州的埃德娜·贝内特·皮尔斯预防研究中心进行 州立大学，一个理想和蓬勃发展的研究机构，将为候选人提供所有 她需要的资源，以实现她的研究议程和培训目标。候选人将由以下人员指导 具有独特和重叠技能的跨学科专家团队：斯蒂芬妮·兰扎博士( 密集的纵向数据分析)，Jennifer Maggs博士(物质使用理论框架专家 Joshua Smyth博士(EMA方法学专家)和Emily Ansell博士(EMA方法学专家 瞬间大麻评估)。此K01申请表中概述的职业发展计划将允许 (1)年轻人中有问题的物质使用行为；(2) 即刻评估高危饮酒行为及其相关因素；(3)复杂密集分析 纵向数据，以及(4)产生高影响力的论文和成功的拨款申请，以推进 在共同使用方面发挥领导作用。研究计划和培训活动将有助于林登-卡迈克尔博士长期 职业目标是建立一个独立的研究项目，专注于理解和干预 年轻成年饮酒者中有问题的物质共同使用模式。

Project Summary/Abstract The research plans and tailored training activities proposed in this Mentored Research Scientist Development Award (K01) application will enable the Candidate, Dr. Ashley N. Linden-Carmichael to develop essential skills to build her program of research and transition to independence as an alcohol investigator. Dr. Linden- Carmichael’s work uses innovative methodological and statistical techniques to gain an in-depth understanding of high-risk drinking patterns exhibited by young adults. The current application builds upon her previous work as a National Research Service Award (NRSA; F31) pre-doctoral fellow by studying an emerging public health concern: simultaneous alcohol and marijuana (SAM) use (i.e., using alcohol and marijuana at the same time). SAM use is particularly problematic because the use of both substances can interact to produce a synergistic effect on impairment. The proposed research activities aim to fill several gaps in our basic knowledge of SAM use by providing detailed, momentary information on the predictors and consequences of SAM use patterns through the innovative use of wearable alcohol sensors and ecological momentary assessments. Specifically, the two studies proposed aim to better understand SAM use patterns by (1) developing a brief measure of SAM use motives for use in ecological momentary assessment (EMA) surveys; (2) using EMA to identify person-, day-, and moment-level predictors of SAM use; (3) applying novel intensive longitudinal data methods to characterize dynamic features of alcohol intoxication within SAM and alcohol-only use episodes; and (4) comparing day-level consequences of episodes of SAM use versus use of either substance alone. This research will be conducted in The Edna Bennett Pierce Prevention Research Center at The Pennsylvania State University, an ideal and thriving research institution that will provide the Candidate with all of the resources she needs to carry out her research agenda and training goals. The Candidate will be mentored by an interdisciplinary team of experts with unique and overlapping skillsets: Dr. Stephanie Lanza (expert in intensive longitudinal data analysis), Dr. Jennifer Maggs (expert in theoretical frameworks for substance use across the lifespan), Dr. Joshua Smyth (expert in EMA methodology), and Dr. Emily Ansell (expert in momentary marijuana assessment). The career development plan outlined in this K01 application will allow the Candidate to obtain essential training on (1) problematic substance use behavior among young adults, (2) assessing high-risk drinking behavior and its correlates in the moment, (3) analyzing complex intensive longitudinal data, and (4) producing high-impact papers and successful grant applications to advance leadership in co-use. The research plan and training activities will facilitate Dr. Linden-Carmichael’s long-term career goal of building an independent program of research focused on understanding and intervening on problematic substance co-use patterns among young adult drinkers.