Simultaneous Alcohol and Marijuana Use: Momentary Influences and Consequences

项目总结/摘要 本指导研究科学家发展计划中提出的研究计划和定制培训活动 奖项（K 01）申请将使候选人，博士阿什利N。Linden-Carmichael开发基本技能 建立她的研究计划，并过渡到独立作为一个酒精调查员。林登医生- 卡迈克尔的工作使用创新的方法和统计技术，以获得深入的了解 年轻人的高危饮酒模式。目前的应用程序建立在她以前的工作基础上 作为国家研究服务奖（NRSA; F31）博士前研究员，通过研究新兴的公共卫生 关注：同时使用酒精和大麻（SAM）（即，同时使用酒精和大麻）。 SAM的使用是特别成问题的，因为两种物质的使用可以相互作用以产生协同效应。 对减值的影响。拟议的研究活动旨在填补我们对SAM基本知识的几个空白 通过提供有关SAM使用模式的预测因素和后果的详细、瞬时信息来使用 通过创新使用可穿戴酒精传感器和生态瞬时评估。具体地说， 提出的两项研究旨在通过以下方法更好地了解SAM使用模式：（1）制定一个简单的衡量标准， SAM使用动机用于生态瞬时评估（EMA）调查;（2）使用EMA识别 SAM使用的人、天和时刻水平预测因子;（3）应用新的密集纵向数据方法 描述SAM和仅使用酒精事件中酒精中毒的动态特征;以及（4） 比较SAM使用与单独使用任何一种物质的事件的日水平后果。这 研究将在宾夕法尼亚州的埃德娜班尼特皮尔斯预防研究中心进行 州立大学，一个理想的和蓬勃发展的研究机构，将提供候选人的所有 她需要的资源来执行她的研究议程和培训目标。候选人将接受以下人员的指导： 具有独特和重叠技能的跨学科专家团队：Stephanie Lanza博士（ Jennifer Maggs博士（药物使用理论框架专家 约书亚史密斯博士（EMA方法学专家）和艾米丽安塞尔博士（EMA方法学专家）。 暂时大麻评估）。K 01申请中概述的职业发展计划将允许 候选人获得基本培训（1）年轻人中有问题的物质使用行为，（2） 评估当前高危饮酒行为及其相关因素，（3）分析复杂强化 纵向数据，以及（4）产生高影响力的论文和成功的赠款申请，以促进 共同使用的领导力。研究计划和培训活动将促进林登-卡迈克尔博士的长期 建立一个独立的研究计划的职业目标，重点是理解和干预 年轻成年饮酒者中有问题的物质共同使用模式。

Project Summary/Abstract The research plans and tailored training activities proposed in this Mentored Research Scientist Development Award (K01) application will enable the Candidate, Dr. Ashley N. Linden-Carmichael to develop essential skills to build her program of research and transition to independence as an alcohol investigator. Dr. Linden- Carmichael’s work uses innovative methodological and statistical techniques to gain an in-depth understanding of high-risk drinking patterns exhibited by young adults. The current application builds upon her previous work as a National Research Service Award (NRSA; F31) pre-doctoral fellow by studying an emerging public health concern: simultaneous alcohol and marijuana (SAM) use (i.e., using alcohol and marijuana at the same time). SAM use is particularly problematic because the use of both substances can interact to produce a synergistic effect on impairment. The proposed research activities aim to fill several gaps in our basic knowledge of SAM use by providing detailed, momentary information on the predictors and consequences of SAM use patterns through the innovative use of wearable alcohol sensors and ecological momentary assessments. Specifically, the two studies proposed aim to better understand SAM use patterns by (1) developing a brief measure of SAM use motives for use in ecological momentary assessment (EMA) surveys; (2) using EMA to identify person-, day-, and moment-level predictors of SAM use; (3) applying novel intensive longitudinal data methods to characterize dynamic features of alcohol intoxication within SAM and alcohol-only use episodes; and (4) comparing day-level consequences of episodes of SAM use versus use of either substance alone. This research will be conducted in The Edna Bennett Pierce Prevention Research Center at The Pennsylvania State University, an ideal and thriving research institution that will provide the Candidate with all of the resources she needs to carry out her research agenda and training goals. The Candidate will be mentored by an interdisciplinary team of experts with unique and overlapping skillsets: Dr. Stephanie Lanza (expert in intensive longitudinal data analysis), Dr. Jennifer Maggs (expert in theoretical frameworks for substance use across the lifespan), Dr. Joshua Smyth (expert in EMA methodology), and Dr. Emily Ansell (expert in momentary marijuana assessment). The career development plan outlined in this K01 application will allow the Candidate to obtain essential training on (1) problematic substance use behavior among young adults, (2) assessing high-risk drinking behavior and its correlates in the moment, (3) analyzing complex intensive longitudinal data, and (4) producing high-impact papers and successful grant applications to advance leadership in co-use. The research plan and training activities will facilitate Dr. Linden-Carmichael’s long-term career goal of building an independent program of research focused on understanding and intervening on problematic substance co-use patterns among young adult drinkers.